Multifunctional 3-Schiff base-4-hydroxycoumarin derivatives with monoamine oxidase inhibition, anti-β-amyloid aggregation, metal chelation, antioxidant and neuroprotection properties against Alzheimer's disease

RSC Advances ◽  
2015 ◽  
Vol 5 (86) ◽  
pp. 70395-70409 ◽  
Author(s):  
Zhi-Min Wang ◽  
Sai-Sai Xie ◽  
Xue-Mei Li ◽  
Jia-Jia Wu ◽  
Xiao-Bing Wang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Schiff Base ◽  
Monoamine Oxidase ◽  
Metal Chelation ◽  
Amyloid Aggregation ◽  
Monoamine Oxidase Inhibition ◽  
Oxidase Inhibition ◽  
Multifunctional Agents ◽  
Β Amyloid

These 3-Schiff base-4-hydroxycoumarin derivatives were multifunctional agents with monoamine oxidase inhibition, anti-β-amyloid aggregation, metal chelation, antioxidant and neuroprotection properties against Alzheimer's disease.

Multitarget-directed resveratrol derivatives: anti-cholinesterases, anti-β-amyloid aggregation and monoamine oxidase inhibition properties against Alzheimer's disease

MedChemComm ◽  
2014 ◽  
Vol 5 (5) ◽  
pp. 609-616 ◽  
Author(s):  
Long-Fei Pan ◽  
Xiao-Bing Wang ◽  
Sai-Sai Xie ◽  
Su-Yi Li ◽  
Ling-Yi Kong
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Monoamine Oxidase ◽  
Amyloid Aggregation ◽  
Monoamine Oxidase Inhibition ◽  
Oxidase Inhibition ◽  
Β Amyloid ◽  
Resveratrol Derivatives

Resveratrol derivatives were designed and synthesized as multitarget-directed agents for treating AD, and 6r was a balanced inhibitor toward all the tested targets.

Аnticholinesterase and antioxidant activity of new binary conjugates of (с)-carbolines

2019 ◽  
Vol 484 (1) ◽  
pp. 104-108
Author(s):  
G. F. Makhaeva ◽  
E. F. Shevtsova ◽  
N. P. Boltneva ◽  
N. V. Kovaleva ◽  
E. V. Rudakova ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Antioxidant Activity ◽  
Anticholinesterase Activity ◽  
Amyloid Aggregation ◽  
Varying Length ◽  
Β Amyloid ◽  
New Compounds

This study presents the synthesis of binary tetrohydro-γ-carbolines with ditriazol spacers of varying length, which exhibit anticholinesterase and antioxidant activity, as compared to the original Dimebon prototype. Anticholinesterase activity suggests the potential ability of the new compounds to block β-amyloid aggregation induced by anticholinesterase, making them promising candidates for further research preparations for the treatment of Alzheimer's disease. Particular attention should be paid to the conjugate with an intertriazol hexamethylene spacer, which can be regarded as the leading compound in this series.

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