Design, synthesis and evaluation of novel indandione derivatives as multifunctional agents with cholinesterase inhibition, anti-β-amyloid aggregation, antioxidant and neuroprotection properties against Alzheimer’s disease

2016 ◽  
Vol 24 (16) ◽  
pp. 3829-3841 ◽  
Author(s):  
Chandra Bhushan Mishra ◽  
Apra Manral ◽  
Shikha Kumari ◽  
Vikas Saini ◽  
Manisha Tiwari
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cholinesterase Inhibition ◽  
Amyloid Aggregation ◽  
Design Synthesis ◽  
Multifunctional Agents ◽  
Β Amyloid

Multifunctional 3-Schiff base-4-hydroxycoumarin derivatives with monoamine oxidase inhibition, anti-β-amyloid aggregation, metal chelation, antioxidant and neuroprotection properties against Alzheimer's disease

RSC Advances ◽  
2015 ◽  
Vol 5 (86) ◽  
pp. 70395-70409 ◽  
Author(s):  
Zhi-Min Wang ◽  
Sai-Sai Xie ◽  
Xue-Mei Li ◽  
Jia-Jia Wu ◽  
Xiao-Bing Wang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Schiff Base ◽  
Monoamine Oxidase ◽  
Metal Chelation ◽  
Amyloid Aggregation ◽  
Monoamine Oxidase Inhibition ◽  
Oxidase Inhibition ◽  
Multifunctional Agents ◽  
Β Amyloid

These 3-Schiff base-4-hydroxycoumarin derivatives were multifunctional agents with monoamine oxidase inhibition, anti-β-amyloid aggregation, metal chelation, antioxidant and neuroprotection properties against Alzheimer's disease.

scholarly journals Development of novel N-(6-methanesulfonyl-benzothiazol-2-yl)-3-(4-substituted-piperazin-1-yl)-propionamides with cholinesterase inhibition, anti-β-amyloid aggregation, neuroprotection and cognition enhancing properties for the therapy of Alzheimer's disease

RSC Advances ◽  
2020 ◽  
Vol 10 (30) ◽  
pp. 17602-17619 ◽  
Author(s):  
Chandra Bhushan Mishra ◽  
Shruti Shalini ◽  
Siddharth Gusain ◽  
Amresh Prakash ◽  
Jyoti Kumari ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cholinesterase Inhibition ◽  
Amyloid Aggregation ◽  
Β Amyloid ◽  
Multifunctional Ligands

A novel series of benzothiazole–piperazine hybrids were rationally designed, synthesized, and evaluated as multifunctional ligands against Alzheimer's disease (AD).

Аnticholinesterase and antioxidant activity of new binary conjugates of (с)-carbolines

2019 ◽  
Vol 484 (1) ◽  
pp. 104-108
Author(s):  
G. F. Makhaeva ◽  
E. F. Shevtsova ◽  
N. P. Boltneva ◽  
N. V. Kovaleva ◽  
E. V. Rudakova ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Antioxidant Activity ◽  
Anticholinesterase Activity ◽  
Amyloid Aggregation ◽  
Varying Length ◽  
Β Amyloid ◽  
New Compounds

This study presents the synthesis of binary tetrohydro-γ-carbolines with ditriazol spacers of varying length, which exhibit anticholinesterase and antioxidant activity, as compared to the original Dimebon prototype. Anticholinesterase activity suggests the potential ability of the new compounds to block β-amyloid aggregation induced by anticholinesterase, making them promising candidates for further research preparations for the treatment of Alzheimer's disease. Particular attention should be paid to the conjugate with an intertriazol hexamethylene spacer, which can be regarded as the leading compound in this series.

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