scholarly journals Molecular construction of HIV-gp120 discontinuous epitope mimics by assembly of cyclic peptides on an orthogonal alkyne functionalized TAC-scaffold

2016 ◽  
Vol 14 (2) ◽  
pp. 701-710 ◽  
Author(s):  
P. R. Werkhoven ◽  
M. Elwakiel ◽  
T. J. Meuleman ◽  
H. C. Quarles van Ufford ◽  
J. A. W. Kruijtzer ◽  
...  
Keyword(s):  
Cyclic Peptides ◽  
Biologically Active ◽  
Discontinuous Epitope ◽  
Protein Mimics ◽  
Gp120 Protein ◽  
Hiv Gp120

An orthogonally alkyne functionalized TAC-scaffold was used for molecular construction of biologically active gp120 protein mimics containing different peptide loops.

Scaffold optimization in discontinuous epitope containing protein mimics of gp120 using smart libraries

2013 ◽  
Vol 11 (16) ◽  
pp. 2676 ◽  
Author(s):  
Gwenn E. Mulder ◽  
H (Linda). C. Quarles van Ufford ◽  
Jeroen van Ameijde ◽  
Arwin J. Brouwer ◽  
John A. W. Kruijtzer ◽  
...  
Keyword(s):  
Discontinuous Epitope ◽  
Protein Mimics

scholarly journals Applications of Dendrimers in Drug Delivery Agents, Diagnosis, Therapy, and Detection

2014 ◽  
Vol 2014 ◽  
pp. 1-19 ◽  
Author(s):  
B. Noriega-Luna ◽  
Luis A. Godínez ◽  
Francisco J. Rodríguez ◽  
A. Rodríguez ◽  
G. Zaldívar-Lelo de Larrea ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Three Dimensional ◽  
Modified Electrodes ◽  
Biologically Active ◽  
Protein Mimics ◽  
Chemically Modified ◽  
Biological Compatibility ◽  
Variable Chemical ◽  
Diagnostic Applications ◽  
Diagnosis Therapy

In recent years, the application of dendrimers in biomedicine attracted much attention from scientists. Dendrimers are interesting for biomedical applications because of their characteristics, including: a hyperbranching, well-defined globular structures, excellent structural uniformity, multivalency, variable chemical composition, and high biological compatibility. In particular, the three-dimensional architecture of dendrimers can incorporate a variety of biologically active agents to form biologically active conjugates. This review of dendrimers focuses on their use as protein mimics, drug delivery agents, anticancer and antiviral therapeutics, and in biomedical diagnostic applications such as chemically modified electrodes.

Synthesis of biologically active cyclic peptides

Biopolymers ◽  
1981 ◽  
Vol 20 (9) ◽  
pp. 1785-1791 ◽  
Author(s):  
Nobuo Izumiya ◽  
Tetsuo Kato ◽  
Michinori Waki
Keyword(s):  
Cyclic Peptides ◽  
Biologically Active

Generation of biologically active linear and cyclic peptides has revealed a unique fine specificity of rituximab and its possible cross-reactivity with acid sphingomyelinase-like phosphodiesterase 3b precursor

Blood ◽  
2006 ◽  
Vol 107 (3) ◽  
pp. 1070-1077 ◽  
Author(s):  
Federico Perosa ◽  
Elvira Favoino ◽  
Maria Antonietta Caragnano ◽  
Franco Dammacco
Keyword(s):  
Cyclic Peptides ◽  
Cross Reactivity ◽  
Acid Sphingomyelinase ◽  
Biologically Active ◽  
Active Immunotherapy ◽  
Effector Functions ◽  
Fine Specificity ◽  
Phage Display Peptide Library ◽  
Phosphodiesterase 3B ◽  
Anti Cd20

Abstract Heterogeneity of the effector functions displayed by rituximab and other anti-CD20 monoclonal antibodies (mAbs) apparently recognizing the same CD20 epitope suggests that additional mechanisms, probably related to mAb fine specificity, are responsible for B-cell depletion. To improve our understanding of rituximab's function, its fine specificity was investigated by means of phage display peptide library (PDPL)-expressing 7-mer cyclic (c7c) or 7-/12-mer linear peptides. Rituximab-specific c7c PDPL-derived clone insert sequences expressed the motif A(S)NPS overlapping the human CD20 170ANPS173. P172 was the most critical for rituximab binding, since its replacement with S172 (of mouse CD20) abolished the reactivity. The WPXWLE motif expressed by the linear PDPL-derived clone insert sequences could only be aligned to the reverse-oriented 161WPXWLE156 of acid sphingomyelinase-like phosphodiesterase 3b precursor (ASMLPD), though linear peptides bearing WPXWLE competed with cyclic ones for rituximab-paratope binding. Anti-CD20 mAb 1F5 only displayed a reactivity profile similar to that of rituximab, which also reacted with ASMLPD-derived peptides. Peptides induced antibodies with specificity and effector functions similar to those of rituximab. Our results show a unique fine specificity of rituximab, define the molecular basis for the lack of rituximab reactivity with mouse CD20 (mCD20), and the potential of targeting CD20 in an active immunotherapy setting. A possible rituximab interaction with ASMLPD is suggested.

scholarly journals A Review on Pharmacological Properties and Laboratory Outcomes of Flaxseed Diet (Linum usitatissimum)

2021 ◽  
Vol 70 (1) ◽  
Author(s):  
Kanda Bala Bhavana ◽  
A. Narendra Babu ◽  
J. Naga Lakshmi ◽  
B. Deepthi ◽  
G. Kavya
Keyword(s):  
Linolenic Acid ◽  
Linum Usitatissimum ◽  
Cyclic Peptides ◽  
Biologically Active ◽  
Pharmacological Properties ◽  
Soluble Fiber ◽  
Comprehensive Overview ◽  
Therapeutic Benefits ◽  
High Quality Protein ◽  
Prevention And Cure

The current review aimed to provide a comprehensive overview of Bioactive compounds and pharmacological uses, of Linum usitatissimum, and to list its significant therapeutic benefits. From various studies, researchers specified the pharmacological properties of flaxseed. The phytoconstituents like lignan and ? linolenic acid are the richest of flaxseeds. It is also a chief source for soluble fiber, high-quality protein, and antioxidants. Its long trip from old era to the 21st century from being a medication in old age opened the way for a broad populace. Linolenic acid, linoleic acid, lignans, polysaccharides cyclic peptides, alkaloids, cadmium and cyanogenic glycosides were some of the biologically active chemicals and elements. Flaxseed extracts containing lignan or ? linolenic acid were often the focus of biological and clinical research. Some beneficial outcomes for health include decreasing cardiovascular illnesses, atherosclerosis, diabetes, cancer and arthritis, osteoporosis, and autoimmune illnesses, as well as neuroscience. Some Proteins present in flaxseed helps in prevention and cure for cardiovascular disease and reinforce the immune system. This present review focuses briefly on a pharmacological properties and laboratory outcomes of flaxseed diet.

Natural Cyclic Peptides as Clinical and Future Therapeutics

2019 ◽  
Vol 23 (1) ◽  
pp. 38-75 ◽  
Author(s):  
Smritilekha Bera ◽  
Dhananjoy Mondal
Keyword(s):  
Cyclic Peptides ◽  
Cyclic Peptide ◽  
Biologically Active ◽  
New Drugs ◽  
Resistant Bacteria ◽  
Conformationally Constrained ◽  
Therapeutic Landscape ◽  
Low Toxicity ◽  
Alternative Sources ◽  
Essential Resource

Natural cyclic peptides are conformationally constrained notable biomolecules and reveal several drug-like properties such as high binding affinity, metabolic stability, target selectivity, bioavailability, low toxicity and flexibility. They have attracted a lot of attention as alternative sources of new drugs to traditional small molecules in drug discovery. Compared to classical medicines, cyclic peptides with a novel mechanism of action are attractive for their potential therapeutic applications particularly for cancer therapy and several diseases caused by resistant and non-resistant bacteria, virus, and fungi. Herein, we provide an overview of the naturally occurring biologically active cyclic peptide therapeutic landscape, including promising candidates, which are under trial in different stages for future and/or clinically used drugs against different diseases. This will certainly be an essential resource for upcoming and existing researchers and scientists within industry and academia in medicinal, bioorganic, and natural product chemistry.

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