Multifunctional gold nanorods for selective plasmonic photothermal therapy in pancreatic cancer cells using ultra-short pulse near-infrared laser irradiation

Nanoscale ◽  
2015 ◽  
Vol 7 (12) ◽  
pp. 5328-5337 ◽  
Author(s):  
Tania Patino ◽  
Ujjwal Mahajan ◽  
Raghavendra Palankar ◽  
Nikolay Medvedev ◽  
Jakob Walowski ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Laser Irradiation ◽  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Short Pulse ◽  
Pancreatic Cancer Cells ◽  
Infrared Laser Irradiation ◽  
Ultra Short Pulse

RNAi-based therapeutic nanostrategy: IL-8 gene silencing in pancreatic cancer cells using gold nanorods delivery vehicles

2015 ◽  
Vol 26 (36) ◽  
pp. 365101 ◽  
Author(s):  
Nishtha Panwar ◽  
Chengbin Yang ◽  
Feng Yin ◽  
Ho Sup Yoon ◽  
Tjin Swee Chuan ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Gene Silencing ◽  
Cancer Cells ◽  
Gold Nanorods ◽  
Pancreatic Cancer Cells ◽  
Delivery Vehicles

scholarly journals An internal cross-linked polymeric nanoparticle with dual sensitivity for combination therapy of muscle-invasive bladder cancer

2020 ◽  
Author(s):  
Guanchen Zhu ◽  
Kaikai Wang ◽  
Haixiang Qin ◽  
Xiaozhi Zhao ◽  
Wei Chen ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cancer Cells ◽  
Laser Irradiation ◽  
Tumor Cells ◽  
Tumor Targeting ◽  
Near Infrared ◽  
Infrared Laser ◽  
Infrared Laser Irradiation ◽  
Targeting Ability

Abstract Chemotherapy is a standard cancer treatment which uses anti-cancer drugs to destroy or slow the growth of cancer cells. However, chemotherapy has limited therapeutic effects in bladder cancer. One of the reasons of this resistance to chemotherapy is that higher levels of glutathione in invasive bladder cancer cells. We have fabricated nanoparticles that respond to high concentrations of glutathione and near-infrared laser irradiation in order to increase the drug accumulation at the tumor sites and combine chemotherapy with photothermal therapy to overcome the challenges of bladder cancer treatment.Methods:The DOX&IR780@PEG-PCL-SS NPs were prepared by co-precipitation method. We investigated the tumor targeting capability of NPs in vitro and in vivo. The orthotopic bladder cancer model in C57BL/6 mice was established for in vivo study and the photothermal effects and therapeutic efficacy of NPs were evaluated.Results:The DOX&IR780@PEG-PCL-SS NPs were synthesized using internal cross-linking strategy to increase the stability of nanoparticles. Nanoparticles can be ingested by tumor cells in a short time. The DOX&IR780@PEG-PCL-SS NPs have dual sensitivity to high levels of glutathione in bladder cancer cells and near-infrared laser irradiation. Glutathione triggers chemical structural changes of nanoparticles and preliminarily releases drugs, Near-infrared laser irradiation can promote the complete release of the drugs from the nanoparticles and induce a photothermal effect, leading to destroying the tumor cells. Given the excellent tumor-targeting ability and negligible toxicity to normal tissue, DOX&IR780@PEG-PCL-SS NPs can greatly increase the concentration of the anti-cancer drugs in tumor cells. The mice treated with DOX&IR780@PEG-PCL-SS NPs have a significant reduction in tumor volume. The DOX&IR780@PEG-PCL-SS NPs can be tracked by in vivo imaging system and have good tumor targeting ability, to facilitate our assessment during the experiment.Conclusion:A nanoparticle delivery system with dual sensitivity to glutathione and near-infrared laser irradiation was developed for delivering IR780 and DOX. Chemo-photothermal synergistic therapy of both primary bladder cancer and their metastases was achieved using this advanced delivery system.

Stable Incorporation of Gold Nanorods intoN-Isopropylacrylamide Hydrogels and Their Rapid Shrinkage Induced by Near-Infrared Laser Irradiation

Langmuir ◽  
2007 ◽  
Vol 23 (7) ◽  
pp. 4012-4018 ◽  
Author(s):  
Atsushi Shiotani ◽  
Takeshi Mori ◽  
Takuro Niidome ◽  
Yasuro Niidome ◽  
Yoshiki Katayama
Keyword(s):  
Laser Irradiation ◽  
Gold Nanorods ◽  
Near Infrared ◽  
Infrared Laser ◽  
Infrared Laser Irradiation ◽  
Stable Incorporation

scholarly journals Treatment with near-infrared radiation promotes apoptosis in pancreatic cancer cells

2015 ◽  
Vol 10 (3) ◽  
pp. 1836-1840 ◽  
Author(s):  
TOMOHIKO OBAYASHI ◽  
KOHEI FUNASAKA ◽  
EIZABURO OHNO ◽  
RYOJI MIYAHARA ◽  
YOSHIKI HIROOKA ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Infrared Radiation ◽  
Near Infrared ◽  
Near Infrared Radiation ◽  
Pancreatic Cancer Cells

scholarly journals Light-Activatable Transfection System Using Hybrid Vectors Composed of Thermosensitive Dendron Lipids and Gold Nanorods

Pharmaceutics ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 239
Author(s):  
Takuya Hashimoto ◽  
Tomoya Hirata ◽  
Eiji Yuba ◽  
Atsushi Harada ◽  
Kenji Kono
Keyword(s):  
Laser Irradiation ◽  
Gold Nanorods ◽  
Near Infrared ◽  
Infrared Laser ◽  
Target Cells ◽  
Temperature Responsive ◽  
Hybrid Vectors ◽  
Transfection Efficacy ◽  
Infrared Laser Irradiation ◽  
Gene Vectors

Background: Gene delivery to target cells is crucially important to establish gene therapy and regenerative medicine. Although various virus-based and synthetic molecule-based gene vectors have been developed to date, selective transfection in a site or a cell level is still challenging. For this study, both light-responsive and temperature-responsive synthetic gene vectors were designed for spatiotemporal control of a transfection system. Methods: 11-Mercaptoundecanoic acid-coated gold nanorods were mixed with polyamidoamine dendron-bearing lipids of two types having amino-terminus or ethoxydiethylene glycol-terminus to obtain hybrid vectors. Hybrid vectors were mixed further with pDNA. Then we investigated their physicochemical properties and transfection efficacy with or without near infrared laser irradiation. Results: Hybrid vectors formed complexes with pDNA and exhibited enhanced photothermal property under near infrared laser irradiation compared with parent gold nanorods. Transfection efficacy of complexes was promoted considerably by brief laser irradiation soon after complex application to the cells. Analysis of intracellular distribution revealed that laser irradiation promoted the adsorption of complexes to the cells and cytosolic release of pDNA, which is derived from the change in surface hydrophobicity of complexes through dehydration of temperature-responsive groups. Conclusions: Hybrid vector is promising as a light-activatable transfection system.

Novel phthalocyanine-based polymeric micelles with high near-infrared photothermal conversion efficiency under 808 nm laser irradiation for in vivo cancer therapy

2019 ◽  
Vol 7 (14) ◽  
pp. 2247-2251 ◽  
Author(s):  
Lu Li ◽  
Qingzhu Yang ◽  
Lei Shi ◽  
Nannan Zheng ◽  
Zeyu Li ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Cancer Cells ◽  
Laser Irradiation ◽  
Conversion Efficiency ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Polymeric Micelles ◽  
Photothermal Conversion ◽  
Phthalocyanine Molecule

Novel phthalocyanine molecule 4OCSPC with deep NIR absorbance showed excellent photothermal therapy property for cancer cells.

Active Accumulation of Gold Nanorods in Tumor in Response to Near-Infrared Laser Irradiation

2010 ◽  
Vol 21 (11) ◽  
pp. 2049-2054 ◽  
Author(s):  
Atsushi Shiotani ◽  
Yasuyuki Akiyama ◽  
Takahito Kawano ◽  
Yasuro Niidome ◽  
Takeshi Mori ◽  
...  
Keyword(s):  
Laser Irradiation ◽  
Gold Nanorods ◽  
Near Infrared ◽  
Infrared Laser ◽  
Infrared Laser Irradiation ◽  
Active Accumulation

scholarly journals Near-infrared laser-mediated drug release and antibacterial activity of gold nanorod–sputtered titania nanotubes

2018 ◽  
Vol 9 ◽  
pp. 204173141879031 ◽  
Author(s):  
Kyoung-Suk Moon ◽  
Young-Bum Park ◽  
Ji-Myung Bae ◽  
Seunghan Oh
Keyword(s):  
Electron Microscopy ◽  
Laser Irradiation ◽  
Gold Nanorods ◽  
Near Infrared ◽  
Infrared Region ◽  
Infrared Laser ◽  
Gold Nanorod ◽  
Titania Nanotubes ◽  
Infrared Laser Irradiation ◽  
Near Infrared Region

The infection control of implants is one of the hot issues in the field of medicine and dentistry. In this study, we prepared gold nanorod–sputtered titania nanotubes on titanium surface, which is the main component of implant material, and aimed to estimate the remote-controlled tetracycline release and resulting antibacterial effects of gold nanorod–sputtered titania nanotubes using near-infrared laser irradiation. Gold nanorods prepared by ion plasma sputtering (aspect ratio = 1:3) showed optical properties like those of chemically synthesized gold nanorods, exhibiting photothermal effects in the near-infrared region, as demonstrated using field-emission scanning electron microscopy, transmission electron microscopy, and diffuse ultraviolet–visible–near-infrared spectrophotometry. In addition, a 2 wt% tetracycline/polycaprolactone mixture was found to be the most suitable experimental group to demonstrate the biological compatibilities and antibacterial activities. The results of antibacterial agar diffusion tests and near-infrared-mediated tetracycline release tests in vivo confirmed that remote-controlled tetracycline elution using near-infrared laser irradiation was highly effective. Therefore, gold nanorod–sputtered titania nanotubes would be expected to enable the continued use of the photothermal therapy of gold nanorods and extend the limited use of titania showing photocatalytic activity only within the ultraviolet-to-near-infrared region.

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