Two Cu(ii) complexes of triadimefon: crystal structure, antifungal activities and structure–activity relationship

2015 ◽  
Vol 39 (9) ◽  
pp. 6997-7003 ◽  
Author(s):  
Jie Li ◽  
Teng Xi ◽  
Biao Yan ◽  
Mingyan Yang ◽  
Jirong Song ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Dft Calculations ◽  
Electronic Structures ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Antifungal Activities ◽  
Structure Activity ◽  
Theoretical Investigations ◽  
Biocidal Properties

Theoretical investigations of the electronic structures of Cu(ii) complexes carried out by DFT calculations partially explained the increased biocidal properties.

scholarly journals INDANYL ANALOGS AS POTENTIAL ANTIMICROBIAL AGENTS

2018 ◽  
Vol 11 (5) ◽  
pp. 278 ◽  
Author(s):  
Sudip Kumar Mandal
Keyword(s):  
Antimicrobial Agents ◽  
Biological Activities ◽  
Antibacterial Activities ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Dilution Method ◽  
Pathogenic Microorganisms ◽  
Antifungal Activities ◽  
Antibacterial And Antifungal Activities ◽  
Structure Activity

 Objective: The wide variety of biological activities of different indane derivatives makes them an interesting moiety in the field of medicinal chemistry. The objective of the study was to identify and develop novel antimicrobial agents from indanyl analogs.Methods: Recently synthesized indanyl analogs (4a-c and 5a-o) were examined against various pathogenic microorganisms (Gram-positive and Gram-negative bacteria and fungi) using serial dilution method. These analogs were found to possess antibacterial and antifungal activities with minimum inhibitory concentration values ranging between 1.56 and 100 μg/mL.Results: The results revealed that the entire compounds showed mild-to-moderate antibacterial activities and moderate-to-excellent antifungal activities against the pathogenic microorganisms as compared to the standard drugs ciprofloxacin and fluconazole, respectively. Compounds 4a, 5a, 5b, 5d, 5e, 5i, and 5j exhibited antifungal activities superior to the reference drug.Conclusion: Based on the structure-activity relationship, it can conclude that the indan-3-oxo-1-acetic acid moiety is essential for the activities and lipophilic alkoxy substituents on indane ring have enhanced the biological activity. Further, structure-activity relationship studies of the compounds 4a, 5a, and 5b are needful to find the new lead as antimicrobial agent.

Synthesis, antibacterial and antifungal activities of naphthoquinone derivatives: a structure–activity relationship study

2016 ◽  
Vol 25 (6) ◽  
pp. 1274-1285 ◽  
Author(s):  
Juan M. Sánchez-Calvo ◽  
Gara R. Barbero ◽  
Guillermo Guerrero-Vásquez ◽  
Alexandra G. Durán ◽  
Mariola Macías ◽  
...  
Keyword(s):  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Antifungal Activities ◽  
Antibacterial And Antifungal Activities ◽  
Structure Activity ◽  
Relationship Study ◽  
Antibacterial And Antifungal

scholarly journals Antifungal Activity of β-Pinene-Based Hydronopyl Quaternary Ammonium Salts Against Phytopathogenic Fungi

2020 ◽  
Vol 15 (8) ◽  
pp. 1934578X2094836
Author(s):  
Xue Zhen Feng ◽  
Zhuanquan Xiao ◽  
Li Zhang ◽  
Shengliang Liao ◽  
Shangxing Chen ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Plant Pathogens ◽  
Value Added ◽  
Structure Activity Relationship ◽  
Phytopathogenic Fungi ◽  
Activity Relationship ◽  
Resonance Spectroscopy ◽  
Antifungal Activities ◽  
Structure Activity ◽  
Diethyl Ammonium

β-Pinene can be used as a cheap source to synthesize a large number of high value-added derivatives. In this study, a series of β-pinene derivatives was prepared, and the antifungal activities of the compounds were assessed against phytopathogenic fungi. Eight N-alkyl hydronopyl diethyl ammonium halide salts were synthesized by the reaction of hydronopyl diethyl ammonium halide with 8 halogenated alkanes. The structures of the synthesized products were characterized by Fourier-transform infrared spectroscopy and nuclear magnetic resonance spectroscopy and mass spectrometry. The antifungal activities of these derivatives were tested against 11 plant pathogens, and the preliminary structure-activity relationship is discussed. Some derivatives exhibited moderate to significant antifungal activity due to the fusion of the hydronopyl, a long-chain alkyl, bromine, and iodine anionic groups. In contrast to the structure-activity relationship of compounds 2a, 2b, and 2c, iodine ions in 2f, 2g, and 2f had a significant effect on enhancing the antifungal activity against Colletotrichum gloeosporioides, S clerotinia sclerotiorum, Phytophthora capsici, Phomopsis, Sphaeropsis sapinea, Glomerella cingulata, and Fusicoccum aesculi. A higher molecular weight could increase the antifungal activity against Fusarium proliferatum, Alternaria kikuchiana, Sclerotinia sclerotiorum, P. capsici, Phomopsis, and S. sapinea. Compounds 2d and 2e exhibited broad-spectrum antifungal activity against the tested strains. These derivatives are expected to be used as precursor molecules for novel pesticide development in further research.

Discovery, Structure-Activity Relationship Studies, and Crystal Structure of Nonpeptide Inhibitors Bound to the Shank3 PDZ Domain

ChemMedChem ◽  
2011 ◽  
Vol 6 (8) ◽  
pp. 1411-1422 ◽  
Author(s):  
Jörn Saupe ◽  
Yvette Roske ◽  
Christian Schillinger ◽  
Nestor Kamdem ◽  
Silke Radetzki ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Pdz Domain ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Structure Activity
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