Selenium-containing polysaccharides from Ziyang green tea ameliorate high-fructose diet induced insulin resistance and hepatic oxidative stress in mice

2015 ◽  
Vol 6 (10) ◽  
pp. 3342-3350 ◽  
Author(s):  
Daoyuan Ren ◽  
Yuanyuan Hu ◽  
Yiyang Luo ◽  
Xingbin Yang
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Green Tea ◽  
New Variety ◽  
High Fructose Diet ◽  
Hepatic Oxidative Stress ◽  
High Fructose ◽  
Tea Polysaccharides

The present study was designed to evaluate the effects of selenium-containing tea polysaccharides (Se-GTP) from a new variety of selenium-enriched Ziyang green tea against high fructose (HF)-induced insulin resistance and hepatic oxidative stress in mice.

Tartary buckwheat flavonoids ameliorate high fructose-induced insulin resistance and oxidative stress associated with the insulin signaling and Nrf2/HO-1 pathways in mice

2017 ◽  
Vol 8 (8) ◽  
pp. 2803-2816 ◽  
Author(s):  
Yuanyuan Hu ◽  
Zuoxu Hou ◽  
Ruokun Yi ◽  
Zhongming Wang ◽  
Peng Sun ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Drinking Water ◽  
Insulin Signaling ◽  
Tartary Buckwheat ◽  
Hepatic Oxidative Stress ◽  
High Fructose ◽  
Flavonoid Fraction ◽  
And Oxidative Stress

The present study was conducted to explore the effects of a purified tartary buckwheat flavonoid fraction (TBF) on insulin resistance and hepatic oxidative stress in mice fed high fructose in drinking water (20%) for 8 weeks.

scholarly journals Effect of L-Carnitine on Skeletal Muscle Lipids and Oxidative Stress in Rats Fed High-Fructose Diet

2007 ◽  
Vol 2007 ◽  
pp. 1-8 ◽  
Author(s):  
Panchamoorthy Rajasekar ◽  
Carani Venkatraman Anuradha
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Skeletal Muscle ◽  
Intraperitoneal Administration ◽  
Protein Carbonyls ◽  
Sensitivity Index ◽  
Rat Tissues ◽  
High Fructose Diet ◽  
High Fructose ◽  
And Oxidative Stress

There is evidence that high-fructose diet induces insulin resistance, alterations in lipid metabolism, and oxidative stress in rat tissues. The purpose of this study was to evaluate the effect of L-carnitine (CAR) on lipid accumulation and peroxidative damage in skeletal muscle of rats fed high-fructose diet. Fructose-fed animals (60 g/100 g diet) displayed decreased glucose/insulin (G/I) ratio and insulin sensitivity index (ISI0,120) indicating the development of insulin resistance. Rats showed alterations in the levels of triglycerides, free fatty acids, cholesterol, and phospholipids in skeletal muscle. The condition was associated with oxidative stress as evidenced by the accumulation of lipid peroxidation products, protein carbonyls, and aldehydes along with depletion of both enzymic and nonenzymic antioxidants. Simultaneous intraperitoneal administration of CAR (300 mg/kg/day) to fructose-fed rats alleviated the effects of fructose. These rats showed near-normal levels of the parameters studied. The effects of CAR in this model suggest that CAR supplementation may have some benefits in patients suffering from insulin resistance.

scholarly journals Sirt1 and Sirt3 Activation Improved Cardiac Function of Diabetic Rats via Modulation of Mitochondrial Function

Antioxidants ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 338
Author(s):  
Bugga Paramesha ◽  
Mohammed Soheb Anwar ◽  
Himanshu Meghwani ◽  
Subir Kumar Maulik ◽  
Sudheer Kumar Arava ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Cardiac Function ◽  
Mitochondrial Biogenesis ◽  
Mitochondrial Function ◽  
Oroxylin A ◽  
High Fructose Diet ◽  
Functional Parameters ◽  
Insulin Resistant ◽  
High Fructose

In the present study, we aimed to evaluate the effect of Sirt1, Sirt3 and combined activation in high fructose diet-induced insulin resistance rat heart and assessed the cardiac function focusing on mitochondrial health and function. We administered the Sirt1 activator; SRT1720 (5 mg/kg, i.p.), Sirt3 activator; Oroxylin-A (10 mg/kg i.p.) and the combination; SRT1720 + Oroxylin-A (5 mg/kg and 10 mg/kg i.p.) daily from 12th week to 20th weeks of study. We observed significant perturbations of most of the cardiac structural and functional parameters in high fructose diet-fed animals. Administration of SRT1720 and Oroxylin-A improved perturbed cardiac structural and functional parameters by decreasing insulin resistance, oxidative stress, and improving mitochondrial function by enhancing mitochondrial biogenesis, OXPHOS expression and activity in high fructose diet-induced insulin-resistant rats. However, we could not observe the synergistic effect of SRT1720 and Oroxylin-A combination. Similar to in-vivo study, perturbed mitochondrial function and oxidative stress observed in insulin-resistant H9c2 cells were improved after activation of Sirt1 and Sirt3. We observed that Sirt1 activation enhances Sirt3 expression and mitochondrial biogenesis, and the opposite effects were observed after Sirt1 inhibition in cardiomyoblast cells. Taken together our results conclude that activation of Sirt1 alone could be a potential therapeutic target for diabetes-associated cardiovascular complications.

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