scholarly journals Metal complexes of curcumin – synthetic strategies, structures and medicinal applications

2015 ◽  
Vol 44 (15) ◽  
pp. 4986-5002 ◽  
Author(s):  
Simon Wanninger ◽  
Volker Lorenz ◽  
Abdus Subhan ◽  
Frank T. Edelmann
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Metal Complexes ◽  
Disease Activity ◽  
Anticancer Activity ◽  
General Overview

This Tutorial Review provides the first general overview on synthesis and medicinal applications of metal curcumin complexes, including anticancer activity and anti-Alzheimer's disease activity.

Anti-Alzheimer's disease activity of secondary metabolites from Xanthoceras sorbifolia Bunge

2020 ◽  
Vol 11 (3) ◽  
pp. 2067-2079
Author(s):  
Wei Li ◽  
Qiuli Lu ◽  
Xiang Li ◽  
Hongcui Liu ◽  
Liangdi Sun ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Secondary Metabolites ◽  
Disease Activity ◽  
Traditional Medicine ◽  
Tree Species ◽  
Edible Oil

Xanthoceras sorbifolia Bunge is an edible oil tree species peculiar to China and it has long been used as a traditional medicine for enuresis in children. In this paper, X. sorbifolia was found to have significant anti-Alzheimer's activity.

scholarly journals Anti-Alzheimer’s Disease Activity of Bromophenols from a Red Alga, Symphyocladia latiuscula (Harvey) Yamada

ACS Omega ◽  
2019 ◽  
Vol 4 (7) ◽  
pp. 12259-12270 ◽  
Author(s):  
Pradeep Paudel ◽  
Su Hui Seong ◽  
Yajuan Zhou ◽  
Hye Jin Park ◽  
Hyun Ah Jung ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Disease Activity ◽  
Red Alga

scholarly journals Asperterpenes A and B, two unprecedented meroterpenoids from Aspergillus terreus with BACE1 inhibitory activities

2016 ◽  
Vol 7 (10) ◽  
pp. 6563-6572 ◽  
Author(s):  
Changxing Qi ◽  
Jian Bao ◽  
Jianping Wang ◽  
Hucheng Zhu ◽  
Yongbo Xue ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Disease Activity ◽  
Aspergillus Terreus ◽  
Inhibitory Activities

Asperterpenes A and B, two BACE1 inhibitors with unprecedented carbon skeletons isolated fromAspergillus terreus, exhibit potent anti-Alzheimer's disease activity.

scholarly journals A systematic review on anti-Alzheimer's disease activity of prescription Kangen-karyu

2020 ◽  
Vol 14 (2) ◽  
pp. 61-66
Author(s):  
Pradeep Paudel ◽  
Chan Hum Park ◽  
Hyun Ah Jung ◽  
Takako Yokozawa ◽  
Jae Sue Choi
Keyword(s):  
Systematic Review ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Disease Activity

Anti-Alzheimer’s disease activity of compounds from the root bark of Morus alba L.

2017 ◽  
Vol 40 (3) ◽  
pp. 338-349 ◽  
Author(s):  
Eun Bi Kuk ◽  
A. Ra Jo ◽  
Seo In Oh ◽  
Hee Sook Sohn ◽  
Su Hui Seong ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Disease Activity ◽  
Morus Alba ◽  
Root Bark

scholarly journals Bis (Diamines) Cu and Zn Complexes of Flurbiprofen as Potential Cholinesterase Inhibitors: In Vitro Studies and Docking Simulations

Crystals ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 208
Author(s):  
Muhammad Jamil ◽  
Nargis Sultana ◽  
Rizwan Ashraf ◽  
Maryam Bashir ◽  
Muhammad Fayyaz ur Rehman ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Magnetic Susceptibility ◽  
Metal Complexes ◽  
Single Crystal ◽  
Cholinesterase Inhibitors ◽  
Distorted Octahedral Geometry ◽  
X Ray ◽  
Docking Simulations

Alzheimer’s disease (AD) causes dementia and continuous damage to brain cells. Cholinesterase inhibitors can alleviate the condition by increasing communication between the nerve cells and reducing the risk of dementia. In an effort to treat Alzheimer’s disease, we synthesized flurbiprofen-based diamines (1,2 diaminoethane and 1,3 diaminopropane) Zn(II), Cu(II) metal complexes and characterized them by single-crystal X-ray analysis, NMR, (FT)-IR, UV-Vis, magnetic susceptibility, elemental analysis and conductivities measurements. Synthesized diamine metal complexes appeared in ionic forms and have distorted octahedral geometry based on conductivity studies, magnetic susceptibility and electronic studies. Single crystal X-ray diffraction analysis confirmed (2b) Cu(H2O)2(L1)2(L2)2 complex formation. Moreover, we tested all synthesized metal complexes against the cholinesterase enzyme that showed higher inhibition potential. In general, copper metal complexes showed higher inhibitory activities than simple metal complexes with flurbiprofen. These synthesized metal complexes may derive more effective and safe inhibitors for cholinesterases.

scholarly journals Modulation of amyloid-β aggregation by metal complexes with a dual binding mode and their delivery across the blood-brain barrier using focused ultrasound

2021 ◽  
Author(s):  
Ramon Vilar ◽  
Tiffany G Chan ◽  
Carmen Ruehl ◽  
Sophie Morse ◽  
Michelle Simon ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Metal Complexes ◽  
Blood Brain Barrier ◽  
Focused Ultrasound ◽  
Amyloid Β ◽  
Binding Mode ◽  
Brain Barrier ◽  
Amyloid Β Peptide ◽  
Blood Brain

One of the key hallmarks of Alzheimer’s disease is the aggregation of the amyloid-β peptide to form fibrils. Consequently, there has been great interest in studying molecules that can disrupt...

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