Anti-Alzheimer's disease activity of secondary metabolites from Xanthoceras sorbifolia Bunge

2020 ◽  
Vol 11 (3) ◽  
pp. 2067-2079
Author(s):  
Wei Li ◽  
Qiuli Lu ◽  
Xiang Li ◽  
Hongcui Liu ◽  
Liangdi Sun ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Secondary Metabolites ◽  
Disease Activity ◽  
Traditional Medicine ◽  
Tree Species ◽  
Edible Oil

Xanthoceras sorbifolia Bunge is an edible oil tree species peculiar to China and it has long been used as a traditional medicine for enuresis in children. In this paper, X. sorbifolia was found to have significant anti-Alzheimer's activity.

Neuroprotective Activity of the Methanolic Extract of Indigofera aspalathoides against Scopalamine induced Alzheimer's Disease in Experimental Rats

2021 ◽  
pp. 5163-5168
Author(s):  
Rajaram C. ◽  
S. Nelson Kumar ◽  
S. S. Sheeba Tabassum ◽  
Manohar R. ◽  
Sumanjali C.
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Traditional Medicine ◽  
Methanolic Extract ◽  
Therapeutic Potential ◽  
Neuroprotective Effect ◽  
Neuroprotective Activity ◽  
Control Group ◽  
Histological Structure ◽  
Anticancer Activities

The plant Indigofera aspalathoides is a traditional medicine with tremendous therapeutic potential which finds it use in treatment of various ailments such as antibacterial, antioxidant, anti-inflammatory, antidiabetic, and anticancer activities. There are no reports that related to the use of this plant in treating patients with Alzheimer’s disease (AD). Hence present study was aimed to scientifically evaluate the neuroprotective effect of the methanolic extract of Indigofera aspalathoides against scopalamine induced Alzheimer’s disease in experimental rats using behavioral tests like elevated plus maze, Y-maze, and rota-rod tests. In addition to this, biochemical evaluation for acetylcholinesterase activity and histopathological evaluation of brain were done. The results suggests that methanolic extract Indigofera aspalathoides (200mg/kg B.wt and 400mg/kg B.wt) used in this study shows significant improvement of various behavioral parameters like locomotion, anxiety, memory, motor integrity and coordination etc when compared to control group. MEIA inhibited brain AChE enzyme, thereby elevating Ach concentration in brain homogenate and ultimately improved memory of rats. Further, more or less normal histological structure of the hippocampus and all amyloid plaques and neurofibrillary tangles that are formed under the influence of scopolamine disappeared in the rats pretreated with MEIA (200mg/kg B.wt and 400mg/kg B.wt). It can be concluded that our results strongly support the anti-Alzheimer’s potential of the methanolic extract of the plant I.aspalathoides and its use in traditional medicine.

scholarly journals Secondary Metabolites from Plants Possessing Inhibitory Properties against Beta-Amyloid Aggregation as Revealed by Thioflavin-T Assay and Correlations with Investigations on Transgenic Mouse Models of Alzheimer’s Disease

Biomolecules ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. 870 ◽  
Author(s):  
Raluca Stefanescu ◽  
Gabriela Dumitriṭa Stanciu ◽  
Andrei Luca ◽  
Luminita Paduraru ◽  
Bogdan-Ionel Tamba
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Secondary Metabolites ◽  
Transgenic Mouse ◽  
Mouse Models ◽  
Beta Amyloid ◽  
Thioflavin T ◽  
Amyloid Angiopathy ◽  
Transgenic Mouse Models ◽  
Study Results

Alzheimer’s disease is a neurodegenerative disorder for which there is a continuous search of drugs able to reduce or stop the cognitive decline. Beta-amyloid peptides are composed of 40 and 42 amino acids and are considered a major cause of neuronal toxicity. They are prone to aggregation, yielding oligomers and fibrils through the inter-molecular binding between the amino acid sequences (17–42) of multiple amyloid-beta molecules. Additionally, amyloid deposition causes cerebral amyloid angiopathy. The present study aims to identify, in the existing literature, natural plant derived products possessing inhibitory properties against aggregation. The studies searched proved the anti-aggregating effects by the thioflavin T assay and through behavioral, biochemical, and histological analysis carried out upon administration of natural chemical compounds to transgenic mouse models of Alzheimer’s disease. According to our present study results, fifteen secondary metabolites from plants were identified which presented both evidence coming from the thioflavin T assay and transgenic mouse models developing Alzheimer’s disease and six additional metabolites were mentioned due to their inhibitory effects against fibrillogenesis. Among them, epigallocatechin-3-gallate, luteolin, myricetin, and silibinin were proven to lower the aggregation to less than 40%.

scholarly journals Anti-Alzheimer’s Disease Activity of Bromophenols from a Red Alga, Symphyocladia latiuscula (Harvey) Yamada

ACS Omega ◽  
2019 ◽  
Vol 4 (7) ◽  
pp. 12259-12270 ◽  
Author(s):  
Pradeep Paudel ◽  
Su Hui Seong ◽  
Yajuan Zhou ◽  
Hye Jin Park ◽  
Hyun Ah Jung ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Disease Activity ◽  
Red Alga

scholarly journals Asperterpenes A and B, two unprecedented meroterpenoids from Aspergillus terreus with BACE1 inhibitory activities

2016 ◽  
Vol 7 (10) ◽  
pp. 6563-6572 ◽  
Author(s):  
Changxing Qi ◽  
Jian Bao ◽  
Jianping Wang ◽  
Hucheng Zhu ◽  
Yongbo Xue ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Disease Activity ◽  
Aspergillus Terreus ◽  
Inhibitory Activities

Asperterpenes A and B, two BACE1 inhibitors with unprecedented carbon skeletons isolated fromAspergillus terreus, exhibit potent anti-Alzheimer's disease activity.

scholarly journals A systematic review on anti-Alzheimer's disease activity of prescription Kangen-karyu

2020 ◽  
Vol 14 (2) ◽  
pp. 61-66
Author(s):  
Pradeep Paudel ◽  
Chan Hum Park ◽  
Hyun Ah Jung ◽  
Takako Yokozawa ◽  
Jae Sue Choi
Keyword(s):  
Systematic Review ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Disease Activity

Anti-Alzheimer’s disease activity of compounds from the root bark of Morus alba L.

2017 ◽  
Vol 40 (3) ◽  
pp. 338-349 ◽  
Author(s):  
Eun Bi Kuk ◽  
A. Ra Jo ◽  
Seo In Oh ◽  
Hee Sook Sohn ◽  
Su Hui Seong ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Disease Activity ◽  
Morus Alba ◽  
Root Bark
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