Carbamoyl anion-initiated cascade reaction for stereoselective synthesis of substituted α-hydroxy-β-amino amides

2016 ◽  
Vol 52 (5) ◽  
pp. 912-915 ◽  
Author(s):  
Chao-Yang Lin ◽  
Peng-Ju Ma ◽  
Zhao Sun ◽  
Chong-Dao Lu ◽  
Yan-Jun Xu
Keyword(s):  
Stereoselective Synthesis ◽  
Cascade Reaction ◽  
Rapid Construction ◽  
High Yields ◽  
Amino Amides

A carbamoyl anion-initiated cascade reaction with acylsilanes and imines allows rapid construction of substituted α-hydroxy-β-amino amides in high yields with excellent diastereoselectivities.

ChemInform Abstract: Carbamoyl Anion-Initiated Cascade Reaction for Stereoselective Synthesis of Substituted α-Hydroxy-β-Amino Amides.

ChemInform ◽  
2016 ◽  
Vol 47 (20) ◽  
Author(s):  
Chao-Yang Lin ◽  
Peng-Ju Ma ◽  
Zhao Sun ◽  
Chong-Dao Lu ◽  
Yan-Jun Xu
Keyword(s):  
Stereoselective Synthesis ◽  
Cascade Reaction ◽  
Amino Amides

Highly Cumulated Radical Cascade Reaction of aza-1,6-Enyenes: Stereoselective Synthesis of exo -Methylene Piperidines

2020 ◽  
Vol 2020 (11) ◽  
pp. 1700-1707
Author(s):  
Akio Kamimura ◽  
Tomoyuki Itaya ◽  
Tatsuro Yoshinaga ◽  
Ryo Nozawa ◽  
Takuji Kawamoto ◽  
...  
Keyword(s):  
Stereoselective Synthesis ◽  
Cascade Reaction ◽  
Radical Cascade

Stereoselective Synthesis of Diverse Lactones through a Cascade Reaction of Rhodium Carbenoids with Ketoacids

2018 ◽  
Vol 20 (23) ◽  
pp. 7585-7589 ◽  
Author(s):  
Nicholas P. Massaro ◽  
Joseph C. Stevens ◽  
Aayushi Chatterji ◽  
Indrajeet Sharma
Keyword(s):  
Stereoselective Synthesis ◽  
Cascade Reaction ◽  
Rhodium Carbenoids

scholarly journals Efficient synthesis of α-alkyl-β-amino amides by transaminase-mediated dynamic kinetic resolutions

2019 ◽  
Vol 9 (15) ◽  
pp. 4083-4090 ◽  
Author(s):  
Ángela Mourelle-Insua ◽  
Daniel Méndez-Sánchez ◽  
James L. Galman ◽  
Iustina Slabu ◽  
Nicholas J. Turner ◽  
...  
Keyword(s):  
Kinetic Resolution ◽  
Stereoselective Synthesis ◽  
Efficient Synthesis ◽  
Dynamic Kinetic Resolution ◽  
Amino Amides ◽  
Kinetic Resolutions

A transaminase-catalyzed dynamic kinetic resolution is described for the stereoselective synthesis of a series of α-alkyl-β-amino amides.

Stereoselective synthesis of 2,5-disubstituted pyrrolidines via gold-catalysed anti-Markovnikov hydroamination-initiated tandem reactions

2019 ◽  
Vol 55 (67) ◽  
pp. 9923-9926 ◽  
Author(s):  
Tong-De Tan ◽  
Yang-Bo Chen ◽  
Ming-Yang Yang ◽  
Jia-Le Wang ◽  
Hao-Ze Su ◽  
...  
Keyword(s):  
Stereoselective Synthesis ◽  
Tandem Reactions ◽  
Rapid Construction

A series of gold-catalyzed intramolecular hydroamination-initiated azidation, allylation and heteroarylation reactions enable the rapid construction of enantioenriched 2,5-disubstituted pyrrolidines.

A Stereoselective Synthesis of (E)-Allylic Alcohols Via the Hydromagnesiation of Alkynylsilanes

2003 ◽  
Vol 2003 (5) ◽  
pp. 296-298 ◽  
Author(s):  
Mingzhong Cai ◽  
Chunyun Peng ◽  
Hong Zhao ◽  
Wenyan Hao
Keyword(s):  
Stereoselective Synthesis ◽  
Grignard Reagents ◽  
Allylic Alcohols ◽  
High Yields

Hydromagnesiation of alkynylsilanes 1 gives ( Z)-α-silylvinyl Grignard reagents 2, which are reacted with aldehydes or ketones to afford ( Z)-β-silyl allylic alcohols 3 in high yields; intermediates 3 can undergo the desilylation reaction in the presence of anhydrous KF to give ( E)-allylic alcohols 4 in good yields.

Fe-Catalyzed Bisphosphorylation of Amino-2-en-1-ones with Trialkyl Phosphites

Synlett ◽  
2019 ◽  
Vol 30 (09) ◽  
pp. 1090-1094 ◽  
Author(s):  
Shengmei Guo ◽  
Kun Jie ◽  
Ling Huang ◽  
Zhebin Zhang ◽  
Yufeng Wang ◽  
...  
Keyword(s):  
Michael Addition ◽  
Functional Group ◽  
Cascade Reaction ◽  
Trialkyl Phosphites ◽  
High Yields

A facile bisphosphorylation of amino-2-en-1-ones with trialkyl phosphites mediated by iron is developed. The reaction is considered to go through two Michael addition progresses. A variety of amino-2-en-1-ones are bisphosphorylated in high yields with functional group tolerance. In addition, the protocol of introduction of two different phosphates into one molecule is successful through a cascade reaction.

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