A naphthalimide-based [12]aneN3 compound as an effective and real-time fluorescence tracking non-viral gene vector

2015 ◽  
Vol 51 (93) ◽  
pp. 16695-16698 ◽  
Author(s):  
Yong-Guang Gao ◽  
You-Di Shi ◽  
Ying Zhang ◽  
Jing Hu ◽  
Zhong-Lin Lu ◽  
...  
Keyword(s):  
Real Time ◽  
Organic Molecule ◽  
Gene Transfection ◽  
Viral Gene ◽  
Gene Vector ◽  
Macrocyclic Polyamine ◽  
Small Organic Molecule

A small organic molecule containing naphthalimide and macrocyclic polyamine 12[ane]N3 moieties showed effective and fluorescence tracking gene transfection properties.

scholarly journals Real-time Transcriptional Profiling of Cellular and Viral Gene Expression during Lytic Cytomegalovirus Infection

2012 ◽  
Vol 8 (9) ◽  
pp. e1002908 ◽  
Author(s):  
Lisa Marcinowski ◽  
Michael Lidschreiber ◽  
Lukas Windhager ◽  
Martina Rieder ◽  
Jens B. Bosse ◽  
...  
Keyword(s):  
Gene Expression ◽  
Real Time ◽  
Cytomegalovirus Infection ◽  
Transcriptional Profiling ◽  
Viral Gene Expression ◽  
Viral Gene

Synthesis and gene transfection activity of cyclen-based cationic lipids with asymmetric acyl-cholesteryl hydrophobic tails

2014 ◽  
Vol 12 (21) ◽  
pp. 3484-3492 ◽  
Author(s):  
Bao-Quan Liu ◽  
Wen-Jing Yi ◽  
Ji Zhang ◽  
Qiang Liu ◽  
Yan-Hong Liu ◽  
...  
Keyword(s):  
Gene Transfection ◽  
Cationic Lipids ◽  
Viral Gene ◽  
Gene Vectors

Novel cyclen-based cationic lipids with asymmetric acyl-cholesteryl hydrophobic tails were synthesized and applied as non-viral gene vectors.

scholarly journals Plausibly Deniable Chemical Encryption: Hiding a Molecule in a Haystack

2020 ◽  
Author(s):  
Wojciech Nogaś
Keyword(s):  
Chemical Analysis ◽  
Organic Molecule ◽  
Encryption Algorithm ◽  
Proof Of Concept ◽  
Small Organic Molecule ◽  
The Cost

We propose an outline of plausibly deniable chemical encryption algorithm, a technique aimed at increasing the cost of a small organic molecule identification in a sample by means of chemical analysis through mixing it with a rationally designed randomized mixture of analytical interferents, in a remote analogy to other domains of cryptography. The algorithm is then applied in a proof-of-concept demonstration example.

scholarly journals Aliphatic Quaternary Ammonium Functionalized Nanogels for Gene Delivery

Pharmaceutics ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1964
Author(s):  
Huaiying Zhang ◽  
Damla Keskin ◽  
Willy H. de Haan-Visser ◽  
Guangyue Zu ◽  
Patrick van Rijn ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Tertiary Amine ◽  
Quaternary Ammonium ◽  
Gene Transfection ◽  
Genetic Material ◽  
Cationic Lipid ◽  
Endosomal Escape ◽  
Hereditary Diseases ◽  
Viral Gene

Gene therapy is a promising treatment for hereditary diseases, as well as acquired genetic diseases, including cancer. Facing the complicated physiological and pathological environment in vivo, developing efficient non-viral gene vectors is needed for their clinical application. Here, poly(N-isopropylacrylamide) (p(NIPAM)) nanogels are presented with either protonatable tertiary amine groups or permanently charged quaternized ammonium groups to achieve DNA complexation ability. In addition, a quaternary ammonium-functionalized nanogel was further provided with an aliphatic moiety using 1-bromododecane to add a membrane-interacting structure to ultimately facilitate intracellular release of the genetic material. The ability of the tertiary amine-, quaternized ammonium-, and aliphatic quaternized ammonium-functionalized p(NIPAM) nanogels (i.e., NGs, NGs-MI, and NGs-BDD, respectively) to mediate gene transfection was evaluated by fluorescence microscopy and flow cytometry. It is observed that NGs-BDD/pDNA complexes exhibit efficient gene loading, gene protection ability, and intracellular uptake similar to that of NGs-MI/pDNA complexes. However, only the NGs-BDD/pDNA complexes show a notable gene transfer efficiency, which can be ascribed to their ability to mediate DNA escape from endosomes. We conclude that NGs-BDD displays a cationic lipid-like behavior that facilitates endosomal escape by perturbing the endosomal/lysosomal membrane. These findings demonstrate that the presence of aliphatic chains within the nanogel is instrumental in accomplishing gene delivery, which provides a rationale for the further development of nanogel-based gene delivery systems.

Dissolution-enhanced emission of 1,3,6,8-Tetrakis(p-benzoic acid)pyrene for selectively detecting protamine and “on-to-on” heparin detection in water

2021 ◽  
Author(s):  
Hongtao Li ◽  
Yuting Zhang ◽  
Yan Huang ◽  
Dapeng Cao ◽  
Shitao Wang
Keyword(s):  
Detection Limit ◽  
Benzoic Acid ◽  
Organic Molecule ◽  
Basic Protein ◽  
Fluorescence Probe ◽  
Small Organic Molecule ◽  
Turn On ◽  
Low Detection Limit

We developed a small organic molecule, the 1,3,6,8-Tetrakis(pbenzoic acid)pyrene (TBAPy) as a facile turn-on fluorescence probe for selectively detecting the basic protein protamine in water with a low detection limit...

scholarly journals Planar D-π-A Configured Dimethoxy Vinylbenzene Based Small Organic Molecule for Solution-Processed Bulk Heterojunction Organic Solar Cells

2020 ◽  
Vol 10 (17) ◽  
pp. 5743
Author(s):  
Shabaz Alam ◽  
M. Shaheer Akhtar ◽  
Abdullah ◽  
Eun-Bi Kim ◽  
Hyung-Shik Shin ◽  
...  
Keyword(s):  
Solar Cells ◽  
Band Gap ◽  
Power Conversion Efficiency ◽  
Organic Solar Cells ◽  
Organic Molecule ◽  
Bulk Heterojunction ◽  
Power Conversion ◽  
Solution Processed ◽  
Small Organic Molecule ◽  
Donor Material

A new and effective planar D-π-A configured small organic molecule (SOM) of 2-5-(3,5-dimethoxystyryl)thiophen-2-yl)methylene)-1H-indene-1,3(2H)-dione, abbreviated as DVB-T-ID, was synthesized using 1,3-indanedione acceptor and dimethoxy vinylbenzene donor units, connected through a thiophene π-spacer. The presence of a dimethoxy vinylbenzene unit and π-spacer in DVB-T-ID significantly improved the absorption behavior by displaying maximum absorbance at ~515 nm, and the reasonable band gap was estimated as ~2.06 eV. The electronic properties revealed that DVB-T-ID SOMs exhibited promising HOMO (−5.32 eV) and LUMO (−3.26 eV). The synthesized DVB-T-ID SOM was utilized as donor material for fabricating solution-processed bulk heterojunction organic solar cells (BHJ-OSCs) and showed a reasonable power conversion efficiency (PCE) of ~3.1% with DVB-T-ID:PC61BM (1:2, w/w) active layer. The outcome of this work clearly reflects that synthesized DVB-T-ID based on 1,3-indanedione units is a promising absorber (donor) material for BHJ-OSCs.

A PEG-b-poly(disulfide-l-lysine) based redox-responsive cationic polymer for efficient gene transfection

2019 ◽  
Vol 7 (11) ◽  
pp. 1893-1905 ◽  
Author(s):  
Ihsan Ullah ◽  
Jing Zhao ◽  
Shah Rukh ◽  
Khan Muhammad ◽  
Jintang Guo ◽  
...  
Keyword(s):  
Gene Transfection ◽  
Cationic Polymer ◽  
Endosomal Escape ◽  
Gene Vector ◽  
Efficient Gene ◽  
Redox Responsive ◽  
Responsive Gene

A redox responsive gene vector efficiently delivered pDNA with a good internalization tendency, efficient endosomal escape and high nucleus internalization.

Sign in / Sign up

Export Citation Format

Share Document