Synthesis and gene transfection activity of cyclen-based cationic lipids with asymmetric acyl-cholesteryl hydrophobic tails

2014 ◽  
Vol 12 (21) ◽  
pp. 3484-3492 ◽  
Author(s):  
Bao-Quan Liu ◽  
Wen-Jing Yi ◽  
Ji Zhang ◽  
Qiang Liu ◽  
Yan-Hong Liu ◽  
...  
Keyword(s):  
Gene Transfection ◽  
Cationic Lipids ◽  
Viral Gene ◽  
Gene Vectors

Novel cyclen-based cationic lipids with asymmetric acyl-cholesteryl hydrophobic tails were synthesized and applied as non-viral gene vectors.

scholarly journals Cationic lipids with a cyclen headgroup: synthesis and structure–activity relationship studies as non-viral gene vectors

RSC Advances ◽  
2017 ◽  
Vol 7 (30) ◽  
pp. 18681-18689 ◽  
Author(s):  
De-Chun Chang ◽  
Yi-Mei Zhang ◽  
Ji Zhang ◽  
Yan-Hong Liu ◽  
Xiao-Qi Yu
Keyword(s):  
Gene Delivery ◽  
Structure Activity Relationship ◽  
Cationic Lipids ◽  
Activity Relationship ◽  
Viral Gene ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Gene Delivery Vectors ◽  
Gene Vectors ◽  
Viral Gene Delivery

The structure–activity relationships of cyclen-based cationic lipids as non-viral gene delivery vectors were studied and clarified.

Novel imidazole-functionalized cyclen cationic lipids: Synthesis and application as non-viral gene vectors

2013 ◽  
Vol 21 (11) ◽  
pp. 3105-3113 ◽  
Author(s):  
Qiang Liu ◽  
Qian-Qian Jiang ◽  
Wen-Jing Yi ◽  
Ji Zhang ◽  
Xue-Chao Zhang ◽  
...  
Keyword(s):  
Cationic Lipids ◽  
Viral Gene ◽  
Gene Vectors

scholarly journals Lysine-based amino-functionalized lipids for gene transfection: 3D phase behaviour and transfection performance

2018 ◽  
Vol 20 (25) ◽  
pp. 17393-17405 ◽  
Author(s):  
Stephanie Tassler ◽  
Dorota Pawlowska ◽  
Christopher Janich ◽  
Julia Giselbrecht ◽  
Simon Drescher ◽  
...  
Keyword(s):  
Cell Lines ◽  
Gene Transfection ◽  
Cationic Lipids ◽  
Phase Behaviour ◽  
Viral Gene ◽  
Aqueous Dispersions ◽  
Lipid Mixtures

New cationic lipids designed for non-viral gene transfection form lamellar and non-lamellar mesophases in aqueous dispersions. The lipid mixtures with DNA show a panoply of mesophases. Surprisingly, the lamellar lipoplex with OO10 has the best transfection performance in different cell lines.

Hydroxyl-containing non-viral lipidic gene vectors with macrocyclic polyamine headgroups

RSC Advances ◽  
2015 ◽  
Vol 5 (73) ◽  
pp. 59417-59427 ◽  
Author(s):  
Hai-Jiao Wang ◽  
Xi He ◽  
Yang Zhang ◽  
Ji Zhang ◽  
Yan-Hong Liu ◽  
...  
Keyword(s):  
Gene Transfection ◽  
Structure Activity Relationship ◽  
Cationic Lipids ◽  
Activity Relationship ◽  
Macrocyclic Polyamine ◽  
Structure Activity ◽  
Gene Vectors ◽  
Relationship Of

The gene transfection abilities and structure–activity relationship of the newly designed hydroxyl-containing cationic lipids were studied in detail.

Synthesis of bifunctional molecules containing [12]aneN3 and coumarin moieties as effective DNA condensation agents and new non-viral gene vectors

2015 ◽  
Vol 13 (15) ◽  
pp. 4494-4505 ◽  
Author(s):  
Pan Yue ◽  
Ying Zhang ◽  
Zhi-Fo Guo ◽  
Ao-Cheng Cao ◽  
Zhong-Lin Lu ◽  
...  
Keyword(s):  
Gene Transfection ◽  
Dna Condensation ◽  
Viral Gene ◽  
Bifunctional Molecules ◽  
Gene Vectors

Bifunctional molecules with different combinations of [12]aneN3 and coumarin moieties were successfully applied in DNA condensation and gene transfection.

Cationic gemini lipids with cyclen headgroups: interaction with DNA and gene delivery abilities

RSC Advances ◽  
2014 ◽  
Vol 4 (83) ◽  
pp. 44261-44268 ◽  
Author(s):  
Yi-Mei Zhang ◽  
Yan-Hong Liu ◽  
Ji Zhang ◽  
Qiang Liu ◽  
Zheng Huang ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Structure Activity Relationship ◽  
Cationic Lipids ◽  
Activity Relationship ◽  
Viral Gene ◽  
Structure Activity ◽  
Gene Vectors

Eleven Gemini cationic lipids and one mono counterpart were synthesized, and their structure–activity relationship as non-viral gene vectors was studied.

scholarly journals Transient stealth coating of liver sinusoidal wall by anchoring two-armed PEG for retargeting nanomedicines

2020 ◽  
Vol 6 (26) ◽  
pp. eabb8133 ◽  
Author(s):  
Anjaneyulu Dirisala ◽  
Satoshi Uchida ◽  
Kazuko Toh ◽  
Junjie Li ◽  
Shigehito Osawa ◽  
...  
Keyword(s):  
Transfection Efficiency ◽  
Gene Transfection ◽  
Critical Issue ◽  
Viral Gene ◽  
Liver Sinusoids ◽  
Gene Vectors ◽  
Sinusoidal Endothelium ◽  
Poly Ethylene ◽  
Peg Coating

A major critical issue in systemically administered nanomedicines is nonspecific clearance by the liver sinusoidal endothelium, causing a substantial decrease in the delivery efficiency of nanomedicines into the target tissues. Here, we addressed this issue by in situ stealth coating of liver sinusoids using linear or two-armed poly(ethylene glycol) (PEG)–conjugated oligo(l-lysine) (OligoLys). PEG-OligoLys selectively attached to liver sinusoids for PEG coating, leaving the endothelium of other tissues uncoated and, thus, accessible to the nanomedicines. Furthermore, OligoLys having a two-armed PEG configuration was ultimately cleared from sinusoidal walls to the bile, while OligoLys with linear PEG persisted in the sinusoidal walls, possibly causing prolonged disturbance of liver physiological functions. Such transient and selective stealth coating of liver sinusoids by two-arm-PEG-OligoLys was effective in preventing the sinusoidal clearance of nonviral and viral gene vectors, representatives of synthetic and nature-derived nanomedicines, respectively, thereby boosting their gene transfection efficiency in the target tissues.

Zn-promoted gene transfection efficiency for non-viral vectors: a mechanism study

2021 ◽  
Author(s):  
Xiao-Qi Yu ◽  
Rui-Mo Zhao ◽  
Yu Guo ◽  
Hui-Zhen Yang ◽  
Ji Zhang
Keyword(s):  
Gene Therapy ◽  
Nucleic Acid ◽  
Gene Delivery ◽  
Viral Vectors ◽  
Transfection Efficiency ◽  
Gene Transfection ◽  
Viral Gene ◽  
Mechanism Study ◽  
High Affinity ◽  
Gene Vectors

The development of cationic non-viral gene vectors that may overcome the obstacles in gene delivery is of great significance to gene therapy. Metallic complexes with high affinity to nucleic acid...

Polycations with excellent gene transfection ability based on PVP-g-PDMAEMA with random coil and micelle structures as non-viral gene vectors

2015 ◽  
Vol 3 (5) ◽  
pp. 911-918 ◽  
Author(s):  
Yuhua Song ◽  
Tingbin Zhang ◽  
Xiaoyan Song ◽  
Ling Zhang ◽  
Chunqiu Zhang ◽  
...  
Keyword(s):  
Transfection Efficiency ◽  
Gene Transfection ◽  
Random Coil ◽  
Viral Gene ◽  
Core Shell ◽  
Random Coils ◽  
Gene Vectors ◽  
Spherical Core ◽  
Self Assembled

PVP-g-PDMAEMA formed random coils in water and PVP-g-PDMAEMA-b-PMMA self-assembled into spherical core–shell micelles. Both displayed excellent pDNA compacting abilities at an extremely low N/P ratio, with PVP-g-PDMAEMA-b-PMMA also showing excellent gear transfection efficiency.

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