scholarly journals Assessing the effect of different shapes of glyco-gold nanoparticles on bacterial adhesion and infections

2015 ◽  
Vol 51 (86) ◽  
pp. 15669-15672 ◽  
Author(s):  
Preeti Madhukar Chaudhary ◽  
Sivakoti Sangabathuni ◽  
Raghavendra Vasudeva Murthy ◽  
Ajay Paul ◽  
Hirekodathakallu V. Thulasiram ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Bacterial Infection ◽  
Bacterial Adhesion ◽  
Different Shapes

Different shapes of glyco gold nanoparticles (AuNPs) tune the bacterial aggregations, which can effectively inhibit the bacterial infection of cells.

Potential of rod, sphere and semi-cube shaped gold nanoparticles to induce cytotoxicity and genotoxicity in human blood lymphocytes in vitro

2015 ◽  
Vol 7 (1) ◽  
Author(s):  
Mona A.M. Abo-Zeid ◽  
Thomas Liehr ◽  
Amira M. Gamal-Eldeen ◽  
Mahmoud Zawrah ◽  
Mostafa Ali ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Gold Nanoparticles ◽  
Mitotic Activity ◽  
Human Blood ◽  
Human Peripheral Blood ◽  
Human Lymphocytes ◽  
Blood Lymphocytes ◽  
Human Blood Lymphocytes ◽  
Different Shapes

AbstractGold nanoparticles (GNPs) are intended to be used in nanomedicine. Due to nanotechnology innovation GNPs of variable sizes and in different shapes including rods, spheres, cubes, etc., can easily be produced. The aim of the present studies was to evaluate the cyto-and genotoxicity inducible by different shaped GNPs on normal human peripheral blood lymphocytes.Four different shapes of GNPs including big rod GNPs (BR-GNPs, 50 nm), small rod GNPs (SR-GNPs, 30 nm), sphere GNPs (S-GNPs, 15 nm) and semi-cube GNPs (SC-GNPs, 15 nm) were studied. Cultured human blood lymphocytes were treated with different concentrations of these GNPs for 24 h in vitro. Cytotoxicity was evaluated based on the mitotic index (MI), while genotoxicity was studied by an interphase-fluorescence in situ hybridization (I-FISH) assay. The following genes were studied in I-FISH:The lowest concentration of BR-GNPs neither had an effect mitotic activity nor enhanced gain or loss of examined gene signals in a significant manner with I-FSH. Other concentrations of BR-GNPs, SR-GNPs, S-GNPs and SC-GNPs with all concentrations inhibited the mitotic activity of the cells and reduced the cell proliferation highly significantly. The different types of GNPs initiated the duplication ofGNPs at high concentration can reduce the cell proliferation and induce DNA damage. Low concentration of rod-shaped GNPs at 50 nm was safe on human lymphocytes. Further research studies are required to optimize the concentration, shape and size of GNPs before using them in nanomedicine.

An ultrasensitive ELISA method for the detection of procalcitonin based on magnetic beads and enzyme-antibody labeled gold nanoparticles

2016 ◽  
Vol 8 (7) ◽  
pp. 1577-1585 ◽  
Author(s):  
Tao Liao ◽  
Fang Yuan ◽  
Haoyang Yu ◽  
Zigang Li
Keyword(s):  
Gold Nanoparticles ◽  
Severe Sepsis ◽  
Mortality Rate ◽  
Bacterial Infection ◽  
Magnetic Beads ◽  
Specific Marker ◽  
Elisa Method ◽  
Significant Mortality

Sepsis is a potentially fatal systemic body infection with a significant mortality rate worldwide. Procalcitonin (PCT) is a specific marker for severe sepsis caused by bacterial infection. Herein, an ultrasensitive ELISA method based on magnetic beads and enzyme-antibody labeled gold nanoparticles was reported for the detection of PCT.

scholarly journals The Properties of Nano-Gold Particles Synthesized by Ascorbic Acid With Acacia Gum and Sodium Hydroxide as Stabilizers

2019 ◽  
pp. 2149-2155
Author(s):  
Dhelal Abdul Ghafoor ◽  
Rana M. Yas ◽  
Muna Ahmed Saeed
Keyword(s):  
Gold Nanoparticles ◽  
Ascorbic Acid ◽  
Sodium Hydroxide ◽  
Wave Length ◽  
Chloroauric Acid ◽  
Nano Particle ◽  
Nano Gold ◽  
Acacia Gum ◽  
Different Shapes ◽  
Uv Visible

In this work, biocompatible gold nanoparticles were synthesized by reducing the chloroauric acid with ascorbic acid as a reducing agent. Colloidal gold nanoparticles were stabilized through nontoxic acacia gum sodium hydroxide .Synthesizing gold nano particle is confirmed by the change in color of chloroauric acid from yellow to ruby red and brown color depending on the stabilizers. The gold nanoparticles were characterized by UV-Visible spectrophotometer. Where the peak of the absorbance of surface plasmon resonance (SPR) was observed between the wave length 526 and 535 nm. The results of zeta potential were found in rang (-19, -40 mv), AFM and TEM images show two different shapes, hexagonal and spherical and the size of gold nanoparticles between 21.5nm and  29nm.

scholarly journals Aqueous-Phase Catalytic Chemical Reduction of p-Nitrophenol Employing Soluble Gold Nanoparticles with Different Shapes

Catalysts ◽  
2016 ◽  
Vol 6 (12) ◽  
pp. 215 ◽  
Author(s):  
Francyelle de Oliveira ◽  
Lucas Nascimento ◽  
Claudia Calado ◽  
Mario Meneghetti ◽  
Monique da Silva
Keyword(s):  
Gold Nanoparticles ◽  
Aqueous Phase ◽  
Chemical Reduction ◽  
Different Shapes

Antimicrobial peptide modification enhances the gene delivery and bactericidal efficiency of gold nanoparticles for accelerating diabetic wound healing

2018 ◽  
Vol 6 (10) ◽  
pp. 2757-2772 ◽  
Author(s):  
Song Wang ◽  
Chang Yan ◽  
Ximu Zhang ◽  
Dezhi Shi ◽  
Luxiang Chi ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Wound Healing ◽  
Gene Delivery ◽  
Bacterial Infection ◽  
Antimicrobial Peptide ◽  
Diabetic Wound ◽  
Peptide Modification ◽  
Diabetic Wound Healing ◽  
Bactericidal Efficiency ◽  
Impaired Angiogenesis

Impaired angiogenesis and bacterial infection have increasingly been implicated as the major causes of delayed diabetic wound healing.

Lubricin as a Surface Treatment to Reduce Post-operative Biofouling and Infection

2012 ◽  
Vol 1486 ◽  
Author(s):  
George E. Aninwene ◽  
Doug Hall ◽  
Amy Mei ◽  
Gregory D. Jay ◽  
Thomas J. Webster
Keyword(s):  
Surface Modification ◽  
Synovial Fluid ◽  
Bacterial Infection ◽  
Bacterial Adhesion ◽  
Surface Coating ◽  
Polymer Surfaces ◽  
Intraocular Lenses ◽  
Tissue Cultures ◽  
Bacteria Growth ◽  
Adhesive Protein

ABSTRACTThe goal of this research was to investigate the ability of lubricin to prevent bio-fouling of intraocular lenses after surgery, through surface coating trials with lubricin and analogues of the two major sub-units of the lubricin molecule (mucin and vitronectin). Yearly, there are over 6 million surgeries worldwide that involve intraocular lenses (IOLs) 1. However, preventing post-operative biofouling and bacterial infection of these implants remains a challenge 2. Surface modification of IOLs may provide a solution. This study proposes the use of the anti-adhesive protein lubricin (LUB), a glycoprotein found in the synovial fluid, as a means to make polymer surfaces less prone to bacterial adhesion and proliferation; thus, reducing the opportunity for post-operative infection 3. This study used extended bacteria growth trials on tissue cultures polystyrene coated with either lubricin, vitronectin, or mucin to investigate how lubricin and protein sub-regions of lubricin may reduce bacterial adhesion and proliferation.

Bioreduction of chloroaurate ions by geranium leaves and its endophytic fungus yields gold nanoparticles of different shapes

2003 ◽  
Vol 13 (7) ◽  
pp. 1822 ◽  
Author(s):  
S. Shiv Shankar ◽  
Absar Ahmad ◽  
Renu Pasricha ◽  
Murali Sastry
Keyword(s):  
Gold Nanoparticles ◽  
Endophytic Fungus ◽  
Different Shapes
Sign in / Sign up

Export Citation Format

Share Document