Antimicrobial peptide modification enhances the gene delivery and bactericidal efficiency of gold nanoparticles for accelerating diabetic wound healing

2018 ◽  
Vol 6 (10) ◽  
pp. 2757-2772 ◽  
Author(s):  
Song Wang ◽  
Chang Yan ◽  
Ximu Zhang ◽  
Dezhi Shi ◽  
Luxiang Chi ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Wound Healing ◽  
Gene Delivery ◽  
Bacterial Infection ◽  
Antimicrobial Peptide ◽  
Diabetic Wound ◽  
Peptide Modification ◽  
Diabetic Wound Healing ◽  
Bactericidal Efficiency ◽  
Impaired Angiogenesis

Impaired angiogenesis and bacterial infection have increasingly been implicated as the major causes of delayed diabetic wound healing.

A dual functional collagen scaffold coordinates angiogenesis and inflammation for diabetic wound healing

2020 ◽  
Vol 8 (22) ◽  
pp. 6337-6349
Author(s):  
Ge Long ◽  
Dingyang Liu ◽  
Xi He ◽  
Yeyu Shen ◽  
Yannan Zhao ◽  
...  
Keyword(s):  
Wound Healing ◽  
Collagen Scaffold ◽  
Diabetic Patients ◽  
Diabetic Wound ◽  
Dual Functional ◽  
Persistent Inflammation ◽  
Diabetic Wound Healing ◽  
Diabetic Wounds ◽  
Impaired Angiogenesis

Chronic diabetic wounds, which are associated with persistent inflammation and impaired angiogenesis, occur frequently in diabetic patients.

Improved stability of KGF by conjugation with gold nanoparticles for diabetic wound therapy

Nanomedicine ◽  
2019 ◽  
Vol 14 (22) ◽  
pp. 2909-2923 ◽  
Author(s):  
Shuaihua Li ◽  
Qiyu Tang ◽  
Hongbo Xu ◽  
Qiangru Huang ◽  
Zi Wen ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Wound Healing ◽  
Binding Affinity ◽  
Biological Effects ◽  
Diabetic Rats ◽  
Diabetic Wound ◽  
Wound Therapy ◽  
Improved Stability ◽  
Diabetic Wound Healing

Aim: Diabetic wound healing is seriously interrupted, and administration of KGF for wound treatment is restricted by its inherent instability. We aim to develop an ideal way toward KGF stabilization, thus improving diabetic wound healing. Materials & methods: We conjugated KGF with gold nanoparticles (GNPs) and determined the stability and binding affinity. Biological effects of conjugates (KGF-GNPs) were evaluated in vitro and in an animal model. Results: KGF-GNPs revealed high stability under hostile circumstances because of the preserved secondary structure and possessed elevated binding affinity to KGF receptor. Moreover, application of KGF-GNPs contributed to accelerated wound recovery in diabetic rats, including re-epithelialization and contraction. Conclusion: KGF-GNPs were promising for future clinical application for diabetic wound therapy.

Gas-injection of gold nanoparticles and anti-oxidants promotes diabetic wound healing

RSC Advances ◽  
2014 ◽  
Vol 4 (9) ◽  
pp. 4656-4662 ◽  
Author(s):  
Yi-Huei Huang ◽  
Chao-Yi Chen ◽  
Po-Jung Chen ◽  
Shan-Wen Tan ◽  
Chia-Nan Chen ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Wound Healing ◽  
Gas Injection ◽  
Diabetic Wound ◽  
Diabetic Wound Healing

The diabetic wound healing effect of a two-herb formula and its mechanisms of action

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
CBS Lau ◽  
VKM Lau ◽  
CL Liu ◽  
PKK Lai ◽  
JCW Tam ◽  
...  
Keyword(s):  
Wound Healing ◽  
Mechanisms Of Action ◽  
Diabetic Wound ◽  
Healing Effect ◽  
Diabetic Wound Healing ◽  
Wound Healing Effect

Critical Regulation of Angiogenesis by Nrf2 Signaling Is Absent in Diabetic Wound Healing

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 634-P
Author(s):  
PIUL S. RABBANI ◽  
JOSHUA A. DAVID ◽  
DARREN L. SULTAN ◽  
ALVARO P. VILLARREAL-PONCE ◽  
JENNIFER KWONG ◽  
...  
Keyword(s):  
Wound Healing ◽  
Diabetic Wound ◽  
Diabetic Wound Healing
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