A high-performance imaging probe with NIR luminescence and synergistically enhanced T1–T2 relaxivity for in vivo hepatic tumor targeting and multimodal imaging

2015 ◽  
Vol 51 (69) ◽  
pp. 13369-13372 ◽  
Author(s):  
Jian Liu ◽  
Zhengzheng Li ◽  
Xiangliang Yang ◽  
Weisheng Liu ◽  
Baodui Wang ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Multimodal Imaging ◽  
Tumor Targeting ◽  
High Performance ◽  
Hepatic Tumor ◽  
Imaging Probe ◽  
Nir Luminescence

A high-performance nanoprobe with high tumor-targeting efficacy, NIR luminescence and synergistically enhanced T1-/T2-weighted MR imaging in vivo was synthesized.

Synthesis and evaluation of the targeted binding of RGD-containing PEGylated-PEI/DNA polyplex micelles as radiotracers for a tumor-targeting imaging probe

RSC Advances ◽  
2015 ◽  
Vol 5 (130) ◽  
pp. 107455-107465 ◽  
Author(s):  
Adhimoorthy Prasannan ◽  
Tilahun Ayane Debele ◽  
Hsieh-Chih Tsai ◽  
Chiz-Cheng Chao ◽  
Che-Ping Lin ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Ethylene Glycol ◽  
Tumor Targeting ◽  
Poly Ethylene Glycol ◽  
Imaging Probe ◽  
Poly Ethylene

Polyplex micelles with pEGFP and RGD-modified poly(ethylene glycol)-grafted polyethylenimine (E[c(RGDyK)]2-PEG-g-PEI) and were labeled with 99mTc for the in vivo study as proficient probes for molecular imaging.

One-pot synthesis of gadolinium-doped carbon quantum dots for high-performance multimodal bioimaging

2017 ◽  
Vol 5 (1) ◽  
pp. 92-101 ◽  
Author(s):  
Yi Pan ◽  
Jun Yang ◽  
Yaning Fang ◽  
Junhui Zheng ◽  
Rong Song ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Magnetic Resonance ◽  
Mr Imaging ◽  
Hela Cells ◽  
High Performance ◽  
Carbon Quantum Dots ◽  
Pyrolysis Process ◽  
One Pot ◽  
Imaging Probe ◽  
One Pot Synthesis

A high-performance fluorescence (FL)/magnetic resonance (MR) imaging probe is synthesized by doping Gd3+ into carbon quantum dots via a one-pot pyrolysis process, and its dual-modality applications are demonstrated by the use of HeLa cells and mice as models.

Mn-Loaded apolactoferrin dots for in vivo MRI and NIR-II cancer imaging

2019 ◽  
Vol 7 (31) ◽  
pp. 9448-9454 ◽  
Author(s):  
Hui Zhou ◽  
Han Yang ◽  
Lin Tang ◽  
Yue Wang ◽  
Yang Li ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Cancer Imaging ◽  
Imaging Probe

The dual modal imaging probe H-dot was prepared for in vivo NIR-II/MR imaging of orthotopic U87MG glioblastoma xenografts.

Neodymium-doped NaHoF4 nanoparticles as near-infrared luminescent/T2-weighted MR dual-modal imaging agents in vivo

2017 ◽  
Vol 5 (3) ◽  
pp. 504-510 ◽  
Author(s):  
Yamin Feng ◽  
Qingbo Xiao ◽  
Yanhui Zhang ◽  
Fujin Li ◽  
Yanfang Li ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Near Infrared ◽  
Imaging Agents ◽  
Nir Luminescence

Efficient NIR luminescence and high r2 value are simultaneously achieved for NaHoF4:Nd3+ nanoplates, which are successfully applied for NIR luminescence and MR imaging in vivo.

scholarly journals Uniform Fe3O4/Gd2O3-DHCA nanocubes for dual-mode MR imaging

2020 ◽  
Author(s):  
Miao Qin ◽  
Yueyou Peng ◽  
Mengjie Xu ◽  
Hui Yan ◽  
Yizhu Cheng ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Mr Imaging ◽  
Contrast Agent ◽  
Contrast Agents ◽  
Clinical Diagnosis ◽  
Multimodal Imaging ◽  
Experimental Results ◽  
Dual Mode ◽  
3.0 T

Multimodal imaging technology were extensively studied over past few years, because they offered complementary diagnosis information, which can increase the accuracy of diagnosis. The synthesis of contrast agents via simplified methods are desired for the development of multimodal imaging. Herein, uniformly distributed Fe3O4/Gd2O3 nanocubes for T1-T2 dual-mode contrast agents were rationally designed and successfully fabricated by our group. In this system, the Fe3O4/Gd2O3 nanocubes were coated with nontoxic 3,4-dihydroxyhydrocinnamic acid (DHCA) for better hydrophilia and biocompatibility. The results show that Ferrum (Fe) and Gadolinium (Gd) elements are homo-dispersity in the Fe3O4/Gd2O3-DHCA (FGDA) nanocubes. Relaxivity study at 3.0 T scanner demonstrates that the r1 value and r2 value of FGDA nanocubes reach up to 67.57 ± 6.2 mM-1s-1 and 24.2 ± 1.46 mM-1s-1. The images of T1-weighted and T2-weighted imaging in vivo demonstrate that FGDA nanocubes possess the ability of magnetic resonance (MR) imaging enhancement as dual-mode contrast agent. The above illustrated experimental results indicate that FGDA nanocubes can be applied in clinical diagnosis in future.

A novel αvβ3 integrin-targeted NIR-II nanoprobe for multimodal imaging-guided photothermal therapy of tumors in vivo

Nanoscale ◽  
2020 ◽  
Vol 12 (13) ◽  
pp. 6953-6958 ◽  
Author(s):  
Meng Zhao ◽  
Jianan Ding ◽  
Qiulian Mao ◽  
Yuqi Zhang ◽  
Yinjia Gao ◽  
...  
Keyword(s):  
Malignant Tumor ◽  
Photothermal Therapy ◽  
Multimodal Imaging ◽  
Tumor Targeting ◽  
Spect Imaging ◽  
Αvβ3 Integrin ◽  
Rgd Peptides

A novel NIR-II probe QT-RGD consisting of a NIR-II fluorophore and two tumor-targeting cyclic-RGD peptides was reported. In vitro and in vivo studies show that it could be successfully used for multimodal NIR-II/PA/SPECT imaging and photothermal therapy of malignant tumor.

scholarly journals Fluorescent Silicon Nanorods-Based Nanotheranostic Agents for Multimodal Imaging-Guided Photothermal Therapy

2019 ◽  
Vol 11 (1) ◽  
Author(s):  
Mingyue Cui ◽  
Sangmo Liu ◽  
Bin Song ◽  
Daoxia Guo ◽  
Jinhua Wang ◽  
...  
Keyword(s):  
Thermal Imaging ◽  
Photothermal Therapy ◽  
Multimodal Imaging ◽  
High Performance ◽  
Peptide Ligands ◽  
Infrared Thermal Imaging ◽  
Targeting Peptide ◽  
Tumor Accumulation ◽  
Silicon Based

Abstract The utilization of diagnosis to guide/aid therapy procedures has shown great prospects in the era of personalized medicine along with the recognition of tumor heterogeneity and complexity. Herein, a kind of multifunctional silicon-based nanostructure, i.e., gold nanoparticles-decorated fluorescent silicon nanorods (Au@SiNRs), is fabricated and exploited for tumor-targeted multimodal imaging-guided photothermal therapy. In particular, the prepared Au@SiNRs feature high photothermal conversion efficiency (~ 43.9%) and strong photothermal stability (photothermal performance stays constant after five-cycle NIR laser irradiation), making them high-performance agents for simultaneously photoacoustic and infrared thermal imaging. The Au@SiNRs are readily modified with targeting peptide ligands, enabling an enhanced tumor accumulation with a high value of ~ 8.74% ID g−1. Taking advantages of these unique merits, the Au@SiNRs are superbly suitable for specifically ablating tumors in vivo without appreciable toxicity under the guidance of multimodal imaging. Typically, all the mice treated with the Au@SiNRs remain alive, and no distinct tumor recurrence is observed during 60-day investigation.

scholarly journals In Vivo Targeting of Underglycosylated MUC-1 Tumor Antigen Using a Multimodal Imaging Probe

2004 ◽  
Vol 64 (5) ◽  
pp. 1821-1827 ◽  
Author(s):  
Anna Moore ◽  
Zdravka Medarova ◽  
Andreas Potthast ◽  
Guangping Dai
Keyword(s):  
Tumor Antigen ◽  
Multimodal Imaging ◽  
Imaging Probe

scholarly journals Transrectal Ultrasound and Photoacoustic Imaging Probe for Diagnosis of Prostate Cancer

Sensors ◽  
2021 ◽  
Vol 21 (4) ◽  
pp. 1217
Author(s):  
Jihun Jang ◽  
Jinwoo Kim ◽  
Hak Jong Lee ◽  
Jin Ho Chang
Keyword(s):  
High Performance ◽  
Printed Circuit Board ◽  
Ex Vivo ◽  
Photoacoustic Imaging ◽  
Morphological Changes ◽  
Transrectal Ultrasound ◽  
Circuit Board ◽  
Optical Lens ◽  
Imaging Probe

A combined transrectal ultrasound and photoacoustic (TRUS–PA) imaging probe was developed for the clear visualization of morphological changes and microvasculature distribution in the prostate, as this is required for accurate diagnosis and biopsy. The probe consisted of a miniaturized 128-element 7 MHz convex array transducer with 134.5° field-of-view (FOV), a bifurcated optical fiber bundle, and two optical lenses. The design goal was to make the size of the TRUS–PA probe similar to that of general TRUS probes (i.e., about 20 mm), for the convenience of the patients. New flexible printed circuit board (FPCB), acoustic structure, and optical lens were developed to meet the requirement of the probe size, as well as to realize a high-performance TRUS–PA probe. In visual assessment, the PA signals obtained with the optical lens were 2.98 times higher than those without the lens. Moreover, the in vivo experiment with the xenograft BALB/c (Albino, Immunodeficient Inbred Strain) mouse model showed that TRUS–PA probe was able to acquire the entire PA image of the mouse tight behind the porcine intestine about 25 mm depth. From the ex vivo and in vivo experimental results, it can be concluded that the developed TRUS–PA probe is capable of improving PA image quality, even though the TRUS–PA probe has a cross-section size and an FOV comparable to those of general TRUS probes.

Sign in / Sign up

Export Citation Format

Share Document