Anti-CD155 and anti-CD112 monoclonal antibodies conjugated to a fluorescent mesoporous silica nanosensor encapsulating rhodamine 6G and fluorescein for sensitive detection of liver cancer cells

The Analyst ◽  
2016 ◽  
Vol 141 (16) ◽  
pp. 4933-4940 ◽  
Author(s):  
Liang Tao ◽  
Chaojun Song ◽  
Chenyang Huo ◽  
Yuanjie Sun ◽  
Chunmei Zhang ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Liver Cancer ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cancer Cells ◽  
Rhodamine 6G ◽  
Mesoporous Silica Nanoparticles ◽  
Sensitive Detection ◽  
Liver Cancer Cells

Sensitive detection of liver cancer cells using anti-CD155 and anti-CD112 monoclonal antibodies conjugated to ultrabright fluorescent mesoporous silica nanoparticles (FMSNs) encapsulating Rhodamine 6G and fluorescein was developed.

Controlled Tyrosine Kinase Inhibitor Delivery to Liver Cancer Cells by Gate-Capped Mesoporous Silica Nanoparticles

2019 ◽  
Vol 3 (1) ◽  
pp. 239-251
Author(s):  
Mahsa Sedighi ◽  
Fereshteh Rahimi ◽  
Mohammad-Ali Shahbazi ◽  
Ali Hossein Rezayan ◽  
Helene Kettiger ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Mesoporous Silica ◽  
Tyrosine Kinase ◽  
Tyrosine Kinase Inhibitor ◽  
Silica Nanoparticles ◽  
Cancer Cells ◽  
Kinase Inhibitor ◽  
Mesoporous Silica Nanoparticles ◽  
Liver Cancer Cells

scholarly journals Targeted delivery of mesoporous silica nanoparticles loaded monastrol into cancer cells: an in vitro study

2017 ◽  
Vol 7 (8) ◽  
pp. 549-555 ◽  
Author(s):  
Huzaifa Hanif ◽  
Samina Nazir ◽  
Kehkashan Mazhar ◽  
Muhammad Waseem ◽  
Shazia Bano ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cancer Cells ◽  
Targeted Delivery ◽  
Mesoporous Silica Nanoparticles ◽  
In Vitro Study ◽  
Vitro Study

Gated Mesoporous Silica Nanoparticles for the Controlled Delivery of Drugs in Cancer Cells

Langmuir ◽  
2015 ◽  
Vol 31 (12) ◽  
pp. 3753-3762 ◽  
Author(s):  
Cristina Giménez ◽  
Cristina de la Torre ◽  
Mónica Gorbe ◽  
Elena Aznar ◽  
Félix Sancenón ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cancer Cells ◽  
Mesoporous Silica Nanoparticles ◽  
Controlled Delivery

scholarly journals Cancer cell membrane-modified biodegradable mesoporous silica nanocarriers for berberine therapy of liver cancer

RSC Advances ◽  
2018 ◽  
Vol 8 (70) ◽  
pp. 40288-40297 ◽  
Author(s):  
Juan Yue ◽  
Zheng Wang ◽  
Dan Shao ◽  
Zhimin Chang ◽  
Rui Hu ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cell Membrane ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cancer Cell ◽  
Mesoporous Silica Nanoparticles

We described biodegrade mesoporous silica nanoparticles coating cancer cell membrane for berberine therapy of liver cancer.

scholarly journals Large Pore Mesoporous Silica and Organosilica Nanoparticles for Pepstatin A Delivery in Breast Cancer Cells

Molecules ◽  
2019 ◽  
Vol 24 (2) ◽  
pp. 332 ◽  
Author(s):  
Saher Rahmani ◽  
Jelena Budimir ◽  
Mylene Sejalon ◽  
Morgane Daurat ◽  
Dina Aggad ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cancer Cells ◽  
Cathepsin D ◽  
Breast Cancer Cells ◽  
Potent Inhibitor ◽  
Mesoporous Silica Nanoparticles ◽  
Sol Gel ◽  
Pepstatin A

(1) Background: Nanomedicine has recently emerged as a new area of research, particularly to fight cancer. In this field, we were interested in the vectorization of pepstatin A, a peptide which does not cross cell membranes, but which is a potent inhibitor of cathepsin D, an aspartic protease particularly overexpressed in breast cancer. (2) Methods: We studied two kinds of nanoparticles. For pepstatin A delivery, mesoporous silica nanoparticles with large pores (LPMSNs) and hollow organosilica nanoparticles (HOSNPs) obtained through the sol–gel procedure were used. The nanoparticles were loaded with pepstatin A, and then the nanoparticles were incubated with cancer cells. (3) Results: LPMSNs were monodisperse with 100 nm diameter. HOSNPs were more polydisperse with diameters below 100 nm. Good loading capacities were obtained for both types of nanoparticles. The nanoparticles were endocytosed in cancer cells, and HOSNPs led to the best results for cancer cell killing. (4) Conclusions: Mesoporous silica-based nanoparticles with large pores or cavities are promising for nanomedicine applications with peptides.

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