scholarly journals Cancer cell membrane-modified biodegradable mesoporous silica nanocarriers for berberine therapy of liver cancer

RSC Advances ◽  
2018 ◽  
Vol 8 (70) ◽  
pp. 40288-40297 ◽  
Author(s):  
Juan Yue ◽  
Zheng Wang ◽  
Dan Shao ◽  
Zhimin Chang ◽  
Rui Hu ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cell Membrane ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cancer Cell ◽  
Mesoporous Silica Nanoparticles

We described biodegrade mesoporous silica nanoparticles coating cancer cell membrane for berberine therapy of liver cancer.

Cancer cell membrane-cloaked mesoporous silica nanoparticles with a pH-sensitive gatekeeper for cancer treatment

2019 ◽  
Vol 175 ◽  
pp. 477-486 ◽  
Author(s):  
Chang-Ming Liu ◽  
Guang-Bing Chen ◽  
Hui-Hong Chen ◽  
Jia-Bin Zhang ◽  
Hui-Zhang Li ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Mesoporous Silica ◽  
Cancer Treatment ◽  
Silica Nanoparticles ◽  
Cancer Cell ◽  
Mesoporous Silica Nanoparticles ◽  
Ph Sensitive

scholarly journals Construction of homologous cancer cell membrane camouflage in a nano-drug delivery system for the treatment of lymphoma

2020 ◽  
Author(s):  
Qiangqiang Zhao ◽  
Xiaoying Sun ◽  
Bin Wu ◽  
Yinghui Shang ◽  
Xueyuan Huang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Cell Membrane ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cancer Cell ◽  
Ph Value ◽  
Mesoporous Silica Nanoparticles ◽  
Low Ph

Abstract Background: Non-Hodgkin's lymphoma (NHL) possesses great heterogeneity in cytogenetics, immunophenotype and clinical features, and chemotherapy currently serves as the main treatment modality. Although employing monoclonal antibod y targeted drugs has significantly improved its overall efficacy, various patients continue to suffer from drug resistance or recurrence. Chinese medicine has long been used in the treatment of malignant tumors. Therefore, we constructed a low pH value sensitivity drug delivery system based on the cancer cell membrane modified mesoporous silica nanoparticles loaded with traditional Chinese medicine, which can reduce systemic toxicity and improve the therapeutic effect for the targeted drug delivery of tumor cells. Results: Accordingly, this study put forward the construction of a nano-platform based on mesoporous silica nanoparticles (MSNs) loaded with the traditional Chinese medicine isoimperatorin (ISOIM), which was camouflaged by the cancer cell membrane (CCM) called CCM@MSNs-ISOIM. The proposed nano-platform has characteristics of immune escape, anti-phagocytosis, high drug loading rate, low pH value sensitivity, good biocompatibility and active targeting of the tumor site, blocking the lymphoma cell cycle and promoting mitochondrial-mediated apoptosis.Conclusions: Furthermore, this study provides a theoretical basis in finding novel clinical treatments for lymphoma.

scholarly journals Construction of homologous cancer cell membrane camouflage in a nano-drug delivery system for the treatment of lymphoma

2020 ◽  
Author(s):  
Qiangqiang Zhao ◽  
Xiaoying Sun ◽  
Bin Wu ◽  
Yinghui Shang ◽  
Xueyuan Huang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Cell Membrane ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cancer Cell ◽  
Ph Value ◽  
Mesoporous Silica Nanoparticles ◽  
Low Ph

Abstract BackgroundNon-Hodgkin's lymphoma (NHL) possesses great heterogeneity in cytogenetics, immunophenotype and clinical features, and chemotherapy currently serves as the main treatment modality. Although employing monoclonal antibody targeted drugs has significantly improved its overall efficacy, various patients continue to suffer from drug resistance or recurrence. Chinese medicine has long been used in the treatment of malignant tumors. Therefore, we constructed a low pH value sensitivity drug delivery system based on the cancer cell membrane modified mesoporous silica nanoparticles loaded with traditional Chinese medicine, which can reduce systemic toxicity and improve the therapeutic effect for the targeted drug delivery of tumor cells.ResultsAccordingly, this study put forward the construction of a nano-platform based on mesoporous silica nanoparticles (MSNs) loaded with the traditional Chinese medicine isoimperatorin (ISOIM), which was camouflaged by the cancer cell membrane (CCM) called CCM@MSNs-ISOIM. The proposed nano-platform has characteristics of immune escape, anti-phagocytosis, high drug loading rate, low pH value sensitivity, good biocompatibility and active targeting of the tumor site, blocking the lymphoma cell cycle and promoting mitochondrial-mediated apoptosis.ConclusionsFurthermore, this study provides a theoretical basis in finding novel clinical treatments for lymphoma.

scholarly journals Construction of homologous cancer cell membrane camouflage in a nano-drug delivery system for the treatment of lymphoma

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Qiangqiang Zhao ◽  
Xiaoying Sun ◽  
Bin Wu ◽  
Yinghui Shang ◽  
Xueyuan Huang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Cell Membrane ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cancer Cell ◽  
Ph Value ◽  
Mesoporous Silica Nanoparticles ◽  
Low Ph

Abstract Background Non-Hodgkin’s lymphoma (NHL) possesses great heterogeneity in cytogenetics, immunophenotype and clinical features, and chemotherapy currently serves as the main treatment modality. Although employing monoclonal antibody targeted drugs has significantly improved its overall efficacy, various patients continue to suffer from drug resistance or recurrence. Chinese medicine has long been used in the treatment of malignant tumors. Therefore, we constructed a low pH value sensitivity drug delivery system based on the cancer cell membrane modified mesoporous silica nanoparticles loaded with traditional Chinese medicine, which can reduce systemic toxicity and improve the therapeutic effect for the targeted drug delivery of tumor cells. Results Accordingly, this study put forward the construction of a nano-platform based on mesoporous silica nanoparticles (MSNs) loaded with the traditional Chinese medicine isoimperatorin (ISOIM), which was camouflaged by the cancer cell membrane (CCM) called CCM@MSNs-ISOIM. The proposed nano-platform has characteristics of immune escape, anti-phagocytosis, high drug loading rate, low pH value sensitivity, good biocompatibility and active targeting of the tumor site, blocking the lymphoma cell cycle and promoting mitochondrial-mediated apoptosis. Conclusions Furthermore, this study provides a theoretical basis in finding novel clinical treatments for lymphoma.

Multifunctional spherical gold nanocluster aggregate@polyacrylic acid@mesoporous silica nanoparticles for combined cancer dual-modal imaging and chemo-therapy

2015 ◽  
Vol 3 (12) ◽  
pp. 2421-2425 ◽  
Author(s):  
Xiaotong Wu ◽  
Lu Li ◽  
Lingyu Zhang ◽  
Tingting Wang ◽  
Chungang Wang ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Polyacrylic Acid ◽  
Mesoporous Silica Nanoparticles ◽  
Enhanced Fluorescence ◽  
Gold Nanocluster ◽  
Theranostic Agents

Multifunctional nanoparticles with aggregation enhanced fluorescence (AEF) properties were fabricated. The resulting NPs were employed as novel theranostic agents for simultaneous dual-modal imaging and chemo-therapy of liver cancer in vivo and in vitro.

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