A ratiometric lysosomal pH probe based on the naphthalimide–rhodamine system

2015 ◽  
Vol 3 (16) ◽  
pp. 3260-3266 ◽  
Author(s):  
Xiao-Fan Zhang ◽  
Tao Zhang ◽  
Shi-Li Shen ◽  
Jun-Ying Miao ◽  
Bao-Xiang Zhao
Keyword(s):  
Lysosomal Ph ◽  
Ph Changes ◽  
Ph Probe ◽  
System P

The ratiometric pH probe RNL was constructed by integrating the naphthalimide moiety as an FRET donor into the rhodamine moiety as an FRET acceptor. The probe with a pKa of 4.82 could detect pH in the range of 4.50–5.50, selectively stain lysosome and detect lysosomal pH changes.

A ratiometric lysosomal pH probe based on the imidazo[1,5-a]pyridine–rhodamine FRET and ICT system

RSC Advances ◽  
2016 ◽  
Vol 6 (47) ◽  
pp. 41317-41322 ◽  
Author(s):  
Guang-Jie Song ◽  
Su-Yun Bai ◽  
Xi Dai ◽  
Xiao-Qun Cao ◽  
Bao-Xiang Zhao
Keyword(s):  
Fluorescent Probe ◽  
Hela Cells ◽  
Lysosomal Ph ◽  
Ph Probe ◽  
System P ◽  
Ict System ◽  
Low Cytotoxicity ◽  
Ratiometric Fluorescent Probe

A new pH-activatable ratiometric fluorescent probe (RhMP) has been developed based on FRET. This probe displayed good selectivity, and excellent reversibility. In addition, RhMP has low cytotoxicity and has been successfully applied in HeLa cells.

Visual monitoring of the lysosomal pH changes during autophagy with a red-emission fluorescent probe

2020 ◽  
Vol 8 (7) ◽  
pp. 1466-1471 ◽  
Author(s):  
Xiaodong Wang ◽  
Li Fan ◽  
Yubin Wang ◽  
Caihong Zhang ◽  
Wenting Liang ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Living Cells ◽  
Visual Monitoring ◽  
Red Emission ◽  
Lysosomal Ph ◽  
Ph Changes ◽  
Ph Probe

We report a red-emission fluorescent pH probe (RML) for visual monitoring of the lysosomal pH changes during autophagy in living cells.

A ratiometric lysosomal pH probe based on the coumarin–rhodamine FRET system

RSC Advances ◽  
2015 ◽  
Vol 5 (61) ◽  
pp. 49115-49121 ◽  
Author(s):  
Xiao-Fan Zhang ◽  
Tao Zhang ◽  
Shi-Li Shen ◽  
Jun-Ying Miao ◽  
Bao-Xiang Zhao
Keyword(s):  
Lysosomal Ph ◽  
Ph Probe ◽  
System P

The ratiometric pH probe RC1 was constructed by integrating a coumarin moiety as a FRET donor into a rhodamine moiety as a FRET acceptor. The probe with a pKa of 4.98 could detect pH in the range of 4.20–6.00 and selectively stain lysosomes.

Imaging of lysosomal pH changes with a novel quinoline/benzothiazole probe

2018 ◽  
Vol 42 (16) ◽  
pp. 13479-13485 ◽  
Author(s):  
Li Fan ◽  
Ming Nan ◽  
Jinyin Ge ◽  
Xiaodong Wang ◽  
Bo Lin ◽  
...  
Keyword(s):  
Live Cells ◽  
E Coli ◽  
Lysosomal Ph ◽  
Ph Changes ◽  
Ph Probe ◽  
Ph Fluctuations

A fluorescent pH probe BTVQ for imaging lysosomal pH fluctuations in live cells and extreme acidity in E. coli cells.

Real-time tracking lysosomal pH changes under heatstroke and redox stress with a novel near-infrared emissive probe

Talanta ◽  
2021 ◽  
Vol 228 ◽  
pp. 122184
Author(s):  
Qingfeng Xia ◽  
Shumin Feng ◽  
Jiaxin Hong ◽  
Guoqiang Feng
Keyword(s):  
Real Time ◽  
Near Infrared ◽  
Redox Stress ◽  
Lysosomal Ph ◽  
Ph Changes ◽  
Real Time Tracking ◽  
Emissive Probe

A tumor-targeting and lysosome-specific two-photon fluorescent probe for imaging pH changes in living cells

2017 ◽  
Vol 5 (5) ◽  
pp. 988-995 ◽  
Author(s):  
Baoli Dong ◽  
Xuezhen Song ◽  
Xiuqi Kong ◽  
Chao Wang ◽  
Nan Zhang ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Fluorescent Probe ◽  
Tumor Targeting ◽  
Living Cells ◽  
Lysosomal Ph ◽  
Ph Changes ◽  
Two Photon

Lysosomal pH is closely related to the metastasis and apoptosis of cancer cells.

Two-photon fluorescence visualization of lysosomal pH changes during mitophagy and cell apoptosis

Talanta ◽  
2020 ◽  
Vol 209 ◽  
pp. 120549 ◽  
Author(s):  
Yaqi Dong ◽  
Haibin Xiao ◽  
Lingbao Xing ◽  
Chuanchen Wu ◽  
Jin Zhou ◽  
...  
Keyword(s):  
Cell Apoptosis ◽  
Lysosomal Ph ◽  
Ph Changes ◽  
Two Photon ◽  
Two Photon Fluorescence ◽  
Photon Fluorescence

pH-Sensitive Capsules as Intracellular Optical Reporters for Monitoring Lysosomal pH Changes Upon Stimulation

Small ◽  
2012 ◽  
Vol 8 (6) ◽  
pp. 943-948 ◽  
Author(s):  
Pilar RiveraGil ◽  
Moritz Nazarenus ◽  
Sumaira Ashraf ◽  
Wolfgang J. Parak
Keyword(s):  
Ph Sensitive ◽  
Lysosomal Ph ◽  
Ph Changes ◽  
Optical Reporters

scholarly journals Solvatochromic dye LDS 798 as microviscosity and pH probe

2017 ◽  
Vol 19 (44) ◽  
pp. 29934-29939 ◽  
Author(s):  
Hung Doan ◽  
Marlius Castillo ◽  
Micheline Bejjani ◽  
Zhangatay Nurekeyev ◽  
Sergei V. Dzyuba ◽  
...  
Keyword(s):  
Intensity Change ◽  
Ph Changes ◽  
Ph Probe ◽  
Spectral Changes ◽  
Solvatochromic Dye

LDS 798; a known solvatochromic probe is responsive to micro-viscosity and pH changes. Spectral changes can be used to probe polarity while lifetime/intensity change can probe micro-viscosity.

A naphthalene-based fluorescent probe with a large Stokes shift for mitochondrial pH imaging

The Analyst ◽  
2018 ◽  
Vol 143 (20) ◽  
pp. 5054-5060 ◽  
Author(s):  
Bo Lin ◽  
Li Fan ◽  
Jinyin Ge ◽  
Wenjia Zhang ◽  
Caihong Zhang ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Stokes Shift ◽  
Live Cells ◽  
Ph Changes ◽  
Large Stokes Shift ◽  
Ph Probe ◽  
Ph Imaging

A naphthalene-based fluorescent pH probe with a pKa of 8.8 for imaging mitochondrial pH changes in live cells.

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