Plumbagin caged silver nanoparticle stabilized collagen scaffold for wound dressing

2015 ◽  
Vol 3 (7) ◽  
pp. 1415-1425 ◽  
Author(s):  
N. Duraipandy ◽  
Rachita Lakra ◽  
Kunnavakkam Vinjimur Srivatsan ◽  
Usha Ramamoorthy ◽  
Purna Sai Korrapati ◽  
...  
Keyword(s):  
Wound Healing ◽  
Silver Nanoparticle ◽  
Wound Dressing ◽  
Collagen Scaffold ◽  
Cross Linking ◽  
Collagen Scaffolds ◽  
Wound Healing Activity

Wound dressing material based on nano-biotechnological intervention by caging plumbagin on silver nanoparticle (PCSN) as a multi-site cross-linking agent of collagen scaffolds with potent anti-microbial and wound healing activity.

Simultaneous photo-induced cross-linking and silver nanoparticle formation in a PVP electrospun wound dressing

2017 ◽  
Vol 207 ◽  
pp. 145-148 ◽  
Author(s):  
Rita Morais Rosa ◽  
Jorge Carvalho Silva ◽  
Ilda Santos Sanches ◽  
Célia Henriques
Keyword(s):  
Silver Nanoparticle ◽  
Wound Dressing ◽  
Cross Linking ◽  
Nanoparticle Formation

scholarly journals Early and Late Efficacy on Wound Healing of Silver Nanoparticle Gel in Males after Circumcision

2020 ◽  
Vol 9 (6) ◽  
pp. 1822 ◽  
Author(s):  
Matteo Balzarro ◽  
Emanuele Rubilotta ◽  
Nicolò Trabacchin ◽  
Antonio Soldano ◽  
Clara Cerrato ◽  
...  
Keyword(s):  
Wound Healing ◽  
Silver Nanoparticle ◽  
Wound Dressing ◽  
Objective Evaluation ◽  
Oral Antibiotics ◽  
Surgical Wound ◽  
Group A ◽  
The Mean ◽  
Group B

We evaluate the early and late safety and efficacy of silver nanoparticle (AgNPs) in wound healing after circumcision. This multicenter prospective comparative non-randomized observational study compares wound dressing with AgNPs (group A) vs. gentamicin cream (group B). Follow-up included objective evaluation at 10 and 30 days by the Southampton Scoring System (SSS) and Stony Brook Scar Evaluation Scale (SBSES). We enrolled 392 males: 194 in group A, and 198 in group B. At 10 days follow-up, in group A, the SSS scale was grade 1 in 49.5% and grade 2 in the remaining; meanwhile, in group B, grade 1 was in 58%, grade 2 in 34.3%, and grade 4 in 7.6%. At 30 days follow-up, grade 1 healing was 97.4% and 98.4% in group A and B, respectively. At 10 days follow-up, the mean SBSES score was 3.58 and 3.69 in group A and B, respectively; while at 30 days follow-up, 4.81 and 4.76 in group A and B, respectively. Only in group B did 7.6% of males have antibiotic therapy due to pus discharge. No patients needed surgical wound revision. AgNPs led to a late but safer healing, they were non-inferior to the antibiotic cream wound dressing efficacy, and they avoided pus discharge and the need for oral antibiotics due to their polymer material.

scholarly journals Film-Forming Spray of Water-Soluble Chitosan Containing Liposome-Coated Human Epidermal Growth Factor for Wound Healing

Molecules ◽  
2021 ◽  
Vol 26 (17) ◽  
pp. 5326
Author(s):  
Abd. Kakhar Umar ◽  
Sriwidodo Sriwidodo ◽  
Iman Permana Maksum ◽  
Nasrul Wathoni
Keyword(s):  
Wound Healing ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Wound Dressing ◽  
Wound Closure ◽  
Water Soluble ◽  
Film Forming ◽  
Epidermal Growth ◽  
Film Method ◽  
Wound Healing Activity

Human epidermal growth factor (hEGF) has been known to have excellent wound-healing activity. However, direct application to the wound area can lead to low hEGF bioavailability due to protease enzymes or endocytosis. The use of liposomes as coatings and carriers can protect hEGF from degradation by enzymes, chemical reactions, and immune reactions. Sustained release using a matrix polymer can also keep the levels of hEGF in line with the treatment. Therefore, this study aimed to develop a film-forming spray of water-soluble chitosan (FFSWSC) containing hEGF-liposomes as a potential wound dressing. The hEGF-liposomes were prepared using the hydration film method, and the preparation of the FFSWSC was achieved by the ionic gelation method. The hydration film method produced hEGF-liposomes that were round and spread with a Z-average of 219.3 nm and encapsulation efficiency of 99.87%, whereas the film-forming solution, which provided good sprayability, had a formula containing 2% WSC and 3% propylene glycol with a viscosity, spray angle, droplet size, spray weight, and occlusion factor of 21.94 ± 0.05 mPa.s, 73.03 ± 1.28°, 54.25 ± 13.33 µm, 0.14 ± 0.00 g, and 14.57 ± 3.41%, respectively. The pH, viscosity, and particle size of the FFSWSC containing hEGF-liposomes were stable during storage for a month in a climatic chamber (40 ± 2 °C, RH 75 ± 5%). A wound healing activity test on mice revealed that hEGF-liposomes in FFSWSC accelerated wound closure significantly, with a complete wound closure on day 6. Based on the findings, we concluded that FFSWSC containing hEGF-liposomes has the potential to be used as a wound dressing.

An environmentally friendly preparation and characterization of waterborne polyurethane hydrogels by polyvinyl alcohol physical cross-linking to improve water absorption

RSC Advances ◽  
2015 ◽  
Vol 5 (90) ◽  
pp. 73882-73891 ◽  
Author(s):  
Cai Wang ◽  
Yudong Zheng ◽  
Kun Qiao ◽  
Yajie Xie ◽  
Xiaoteng Zhou
Keyword(s):  
Wound Healing ◽  
Water Absorption ◽  
Wound Dressing ◽  
Waterborne Polyurethane ◽  
Cross Linking ◽  
Absorption Kinetics ◽  
Healing Environment ◽  
Three Stages ◽  
High Equilibrium

The PU/PVA hydrogels had three stages of water absorption. The quick absorption kinetics and high equilibrium water absorption of 70% PU/PVA as​ wound dressing material could absorb excess exudate and create a moist wound healing environment.

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