scholarly journals EVALUATION OF ANTIBACTERIAL EFFICACY AND WOUND HEALING ACTIVITY OF NATURAL FIBRE BASED WOUND DRESSING COATED WITH NATURAL EXTRACTS OF CALOTROPIS GIGANTEAN, EUCALYPTUS GLOBULES AND BUDS OF SYZYGIUM AROMATICUM ENHANCED WITH EPIDERMAL GROWTH FACTOR

2017 ◽  
Vol 8 (5) ◽  
pp. 95-100 ◽  
Author(s):  
Ramesh P ◽  
Prakash C ◽  
Sukumar N ◽  
Palaniswamy N K ◽  
Sengottuvelu S
Keyword(s):  
Wound Healing ◽  
Growth Factor ◽  
Wound Dressing ◽  
Natural Fibre ◽  
Syzygium Aromaticum ◽  
Antibacterial Efficacy ◽  
Natural Extracts ◽  
Epidermal Growth ◽  
Eucalyptus Globules ◽  
Wound Healing Activity

scholarly journals Film-Forming Spray of Water-Soluble Chitosan Containing Liposome-Coated Human Epidermal Growth Factor for Wound Healing

Molecules ◽  
2021 ◽  
Vol 26 (17) ◽  
pp. 5326
Author(s):  
Abd. Kakhar Umar ◽  
Sriwidodo Sriwidodo ◽  
Iman Permana Maksum ◽  
Nasrul Wathoni
Keyword(s):  
Wound Healing ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Wound Dressing ◽  
Wound Closure ◽  
Water Soluble ◽  
Film Forming ◽  
Epidermal Growth ◽  
Film Method ◽  
Wound Healing Activity

Human epidermal growth factor (hEGF) has been known to have excellent wound-healing activity. However, direct application to the wound area can lead to low hEGF bioavailability due to protease enzymes or endocytosis. The use of liposomes as coatings and carriers can protect hEGF from degradation by enzymes, chemical reactions, and immune reactions. Sustained release using a matrix polymer can also keep the levels of hEGF in line with the treatment. Therefore, this study aimed to develop a film-forming spray of water-soluble chitosan (FFSWSC) containing hEGF-liposomes as a potential wound dressing. The hEGF-liposomes were prepared using the hydration film method, and the preparation of the FFSWSC was achieved by the ionic gelation method. The hydration film method produced hEGF-liposomes that were round and spread with a Z-average of 219.3 nm and encapsulation efficiency of 99.87%, whereas the film-forming solution, which provided good sprayability, had a formula containing 2% WSC and 3% propylene glycol with a viscosity, spray angle, droplet size, spray weight, and occlusion factor of 21.94 ± 0.05 mPa.s, 73.03 ± 1.28°, 54.25 ± 13.33 µm, 0.14 ± 0.00 g, and 14.57 ± 3.41%, respectively. The pH, viscosity, and particle size of the FFSWSC containing hEGF-liposomes were stable during storage for a month in a climatic chamber (40 ± 2 °C, RH 75 ± 5%). A wound healing activity test on mice revealed that hEGF-liposomes in FFSWSC accelerated wound closure significantly, with a complete wound closure on day 6. Based on the findings, we concluded that FFSWSC containing hEGF-liposomes has the potential to be used as a wound dressing.

scholarly journals Development of stabilized dual growth factor-loaded hyaluronate collagen dressing matrix

2021 ◽  
Vol 12 ◽  
pp. 204173142199975
Author(s):  
Jihyun Kim ◽  
Kyoung-Mi Lee ◽  
Seung Hwan Han ◽  
Eun Ae Ko ◽  
Dong Suk Yoon ◽  
...  
Keyword(s):  
Wound Healing ◽  
Growth Factor ◽  
Type I ◽  
Diabetic Mice ◽  
Patients With Diabetes ◽  
Diabetic Wound Healing ◽  
Epidermal Growth ◽  
Wound Healing Effect ◽  
Growth Factor Production

Patients with diabetes experience impaired growth factor production such as epidermal growth factor (EGF) and basic fibroblast growth factor (bFGF), and they are reportedly involved in wound healing processes. Here, we report dual growth factor-loaded hyaluronate collagen dressing (Dual-HCD) matrix, using different ratios of the concentration of stabilized growth factors—stabilized-EGF (S-EGF) and stabilized-bFGF (S-bFGF). At first, the optimal concentration ratio of S-EGF to S-bFGF in the Dual-HCD matrix is determined to be 1:2 in type I diabetic mice. This Dual-HCD matrix does not cause cytotoxicity and can be used in vivo. The wound-healing effect of this matrix is confirmed in type II diabetic mice. Dual HCD enhances angiogenesis which promotes wound healing and thus, it shows a significantly greater synergistic effect than the HCD matrix loaded with a single growth factor. Overall, we conclude that the Dual-HCD matrix represents an effective therapeutic agent for impaired diabetic wound healing.

Effectiveness of a synthetic human recombinant epidermal growth factor in diabetic patients wound healing : Pilot , double‐blind , randomized clinical controlled trial

2021 ◽  
Author(s):  
Bianca Campos Oliveira ◽  
Beatriz Guitton Renaud Baptista Oliveira ◽  
Gabriela Deutsch ◽  
Fernanda Soares Pessanha ◽  
Selma Rodrigues Castilho
Keyword(s):  
Wound Healing ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Controlled Trial ◽  
Diabetic Patients ◽  
Double Blind ◽  
Epidermal Growth
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