Four related mixed-ligand nickel(ii) complexes: effect of steric encumbrance on the structure, DNA/BSA binding, DNA cleavage and cytotoxicity

RSC Advances ◽  
2015 ◽  
Vol 5 (39) ◽  
pp. 30768-30779 ◽  
Author(s):  
Chun-Yan Gao ◽  
Zhong-Ying Ma ◽  
Yong-Po Zhang ◽  
Si-Tong Li ◽  
Wen Gu ◽  
...  
Keyword(s):  
Dna Binding ◽  
Dna Cleavage ◽  
Mixed Ligand ◽  
Bsa Binding

Four new interrelated mixed-ligand nickel(ii) complexes have been synthesized and characterized. The activities of DNA binding/cleavage, BSA binding with complexes and the vitro cytotoxicity also have been explored.

Copper(II) Complexes of 2-methyl-8-hydroxyquinoline and tri/diimine Co-ligand: DFT Calculation, DNA and BSA Binding, DNA Cleavage, Cytotoxicity and Induction of Apoptosis

2021 ◽  
Author(s):  
Sangeetha Somasundaram ◽  
Tamilarasan Ajaykamal ◽  
Murali Mariappan
Keyword(s):  
Crystal Structure ◽  
Dna Cleavage ◽  
Dft Calculation ◽  
Mixed Ligand ◽  
Bsa Binding ◽  
Induction Of Apoptosis

The mixed ligand copper(II) complexes [Cu(terpy)(mq)]ClO4 (1) and [Cu(phen)(mq)]ClO4 (2), where terpy = 2,2’:6’,2’’-terpyridine, phen = 1,10-phenanthroline and H(mq) = 2-methyl-8-hydroxyquinoline have been synthesised. The crystal structure of 1 discloses...

Mixed ligand copper(II) complexes of 1,10-phenanthroline with tridentate phenolate/pyridyl/(benz)imidazolyl Schiff base ligands: Covalent vs non-covalent DNA binding, DNA cleavage and cytotoxicity

2014 ◽  
Vol 140 ◽  
pp. 255-268 ◽  
Author(s):  
Chandrasekaran Rajarajeswari ◽  
Mani Ganeshpandian ◽  
Mallayan Palaniandavar ◽  
Anvarbatcha Riyasdeen ◽  
Mohammad Abdulkadher Akbarsha
Keyword(s):  
Schiff Base ◽  
Dna Binding ◽  
Dna Cleavage ◽  
Mixed Ligand ◽  
Schiff Base Ligands

Mixed-ligand copper(ii)–sulfonamide complexes: effect of the sulfonamide derivative on DNA binding, DNA cleavage, genotoxicity and anticancer activity

2013 ◽  
Vol 42 (28) ◽  
pp. 10244 ◽  
Author(s):  
Marta González-Álvarez ◽  
Alejandro Pascual-Álvarez ◽  
Lucas del Castillo Agudo ◽  
Alfonso Castiñeiras ◽  
Malva Liu-González ◽  
...  
Keyword(s):  
Dna Binding ◽  
Anticancer Activity ◽  
Dna Cleavage ◽  
Mixed Ligand ◽  
Sulfonamide Derivative

Mixed-ligand copper(ii) Schiff base complexes: the role of the co-ligand in DNA binding, DNA cleavage, protein binding and cytotoxicity

2016 ◽  
Vol 45 (22) ◽  
pp. 9073-9087 ◽  
Author(s):  
Wen-Jing Lian ◽  
Xin-Tian Wang ◽  
Cheng-Zhi Xie ◽  
He Tian ◽  
Xue-Qing Song ◽  
...  
Keyword(s):  
Schiff Base ◽  
Dna Binding ◽  
Protein Binding ◽  
Dna Cleavage ◽  
Mixed Ligand ◽  
Schiff Base Complexes ◽  
Biological Features

Four novel mixed-ligand copper(ii) Schiff base complexes were synthesized and characterized. The biological features of the complexes and how acetic auxiliary ligands manipulate these features were investigated.

Mixed ligand copper(ii) dicarboxylate complexes: the role of co-ligand hydrophobicity in DNA binding, double-strand DNA cleavage, protein binding and cytotoxicity

2015 ◽  
Vol 44 (22) ◽  
pp. 10210-10227 ◽  
Author(s):  
Rangasamy Loganathan ◽  
Sethu Ramakrishnan ◽  
Mani Ganeshpandian ◽  
Nattamai S. P. Bhuvanesh ◽  
Mallayan Palaniandavar ◽  
...  
Keyword(s):  
Dna Binding ◽  
Protein Binding ◽  
Dna Cleavage ◽  
Mixed Ligand ◽  
Double Strand Dna

Mixed ligand 5,6-dmp and 3,4,7,8-tmp complexes display more prominent cytotoxicity and higher apoptotic inducing ability.

Synthesis and Characterisation of RuII Polypyridyl Complexes: DNA-Binding, Photocleavage, and Topoisomerase I and II Inhibitory Activity

2013 ◽  
Vol 66 (11) ◽  
pp. 1406 ◽  
Author(s):  
Xiaojun He ◽  
Guang Yang ◽  
Xiaonan Sun ◽  
Lingjun Xie ◽  
Lifeng Tan
Keyword(s):  
Dna Binding ◽  
Dna Cleavage ◽  
Topoisomerase I ◽  
Mixed Ligand ◽  
Dual Inhibitor ◽  
Cleavage Activity ◽  
Dna Cleavage Activity ◽  
Pbr322 Dna ◽  
Dna Strand ◽  
Strand Passage

Two mixed-ligand ruthenium(ii) complexes [Ru(phen)2(cptcp)]2+ (Ru1; phen = 1,10-phenanthroline, cptcp = 2-(4-carbazol-9-yl-phenyl)-1H-1,3,7,8-tetraaza-cyclopenta-[l]-phenanthrene) and [Ru(phen)2(btcpc)]2+ (Ru2; btcpc = 9-butyl-6-(1H-1,3,7,8-tetraaza-cyclo-cyclopenta-[l]-phenanthren-2-yl)-9H-carbazole-3-carbaldehyde) have been synthesised and characterised. The DNA-binding behaviours of the two complexes have been investigated by using spectroscopic and viscosity measurements. Results suggest that the two complexes bind to DNA by intercalation. The photocleavage of plasmid pBR322 DNA indicates that Ru1 exhibits more effective DNA cleavage activity in comparison to that exhibited by Ru2 under the same conditions, and different cleavage mechanisms are determined. Topoisomerase inhibition and DNA strand passage assay confirm that Ru1 may act as an efficient dual inhibitor of topoisomerases I and II, whereas Ru2 may only act as a single inhibitor of topoisomerases II.

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