scholarly journals Injectable in situ forming hydrogels based on natural and synthetic polymers for potential application in cartilage repair

RSC Advances ◽  
2015 ◽  
Vol 5 (25) ◽  
pp. 19715-19723 ◽  
Author(s):  
Calogero Fiorica ◽  
Fabio Salvatore Palumbo ◽  
Giovanna Pitarresi ◽  
Alessandro Gulino ◽  
Stefano Agnello ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Cartilage Repair ◽  
Potential Application ◽  
Synthetic Polymers ◽  
Injectable Hydrogels ◽  
In Situ Forming ◽  
In Situ Forming Hydrogels ◽  
Natural And Synthetic

Injectable hydrogels based on hyaluronic acid, elastin and a biocompatible polyaspartamide are optimal scaffolds of viable chondrocytes for potential cartilage repair.

Catechol-modified hyaluronic acid: in situ-forming hydrogels by auto-oxidation of catechol or photo-oxidation using visible light

2017 ◽  
Vol 74 (10) ◽  
pp. 4069-4085 ◽  
Author(s):  
Takeshi Sato ◽  
Takao Aoyagi ◽  
Mitsuhiro Ebara ◽  
Rachel Auzély-Velty
Keyword(s):  
Hyaluronic Acid ◽  
Visible Light ◽  
Photo Oxidation ◽  
In Situ Forming ◽  
In Situ Forming Hydrogels

In situ forming hydrogels of hyaluronic acid and inulin derivatives for cartilage regeneration

2015 ◽  
Vol 122 ◽  
pp. 408-416 ◽  
Author(s):  
Fabio S. Palumbo ◽  
Calogero Fiorica ◽  
Mauro Di Stefano ◽  
Giovanna Pitarresi ◽  
Alessandro Gulino ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Cartilage Regeneration ◽  
In Situ Forming ◽  
In Situ Forming Hydrogels

In situ forming hydrogels of new amino hyaluronic acid/benzoyl-cysteine derivatives as potential scaffolds for cartilage regeneration

Soft Matter ◽  
2012 ◽  
Vol 8 (18) ◽  
pp. 4918 ◽  
Author(s):  
Fabio Salvatore Palumbo ◽  
Giovanna Pitarresi ◽  
Calogero Fiorica ◽  
Pietro Matricardi ◽  
Antonella Albanese ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Cartilage Regeneration ◽  
In Situ Forming ◽  
In Situ Forming Hydrogels

scholarly journals Regeneration of critical-sized defects, in a goat model, using a dextrin-based hydrogel associated with granular synthetic bone substitute

2020 ◽  
Author(s):  
Isabel Pereira ◽  
José Eduardo Pereira ◽  
Luís Maltez ◽  
Alexandra Rodrigues ◽  
Catarina Rodrigues ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Bone Substitute ◽  
Bone Substitutes ◽  
Multipotent Mesenchymal Stromal Cells ◽  
Micro Computed Tomography ◽  
Synthetic Bone Substitute ◽  
In Situ Forming ◽  
Bioactive Agents ◽  
In Situ Forming Hydrogels

Abstract The development of injectable bone substitutes (IBS) have obtained great importance in the bone regeneration field, as a strategy to reach hardly accessible defects using minimally invasive techniques and able to fit to irregular topographies. In this scenario, the association of injectable hydrogels and bone graft granules is emerging as a well-established trend. Particularly, in situ forming hydrogels have arisen as a new IBS generation. An in situ forming and injectable dextrin-based hydrogel (HG) was developed, aiming to act as a carrier of granular bone substitutes and bioactive agents. In this work, the HG was associated to a granular bone substitute (Bonelike®) and implanted in goat critical-sized calvarial defects (14 mm) for 3, 6 and 12 weeks. The results showed that HG improved the handling properties of the Bonelike® granules and did not affect its osteoconductive features, neither impairing the bone regeneration process. Human multipotent mesenchymal stromal cells from the umbilical cord, extracellular matrix hydrolysates and the pro-angiogenic peptide LLKKK18 were also combined with the IBS. These bioactive agents did not enhance the new bone formation significantly under the conditions tested, according to micro-computed tomography and histological analysis.

scholarly journals Fabrication of Injectable, Porous Hyaluronic Acid Hydrogel Based on an In-Situ Bubble-Forming Hydrogel Entrapment Process

Polymers ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1138
Author(s):  
Lixuan Wang ◽  
Shiyan Dong ◽  
Yutong Liu ◽  
Yifan Ma ◽  
Jingjing Zhang ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Regenerative Medicine ◽  
In Vivo Studies ◽  
Injectable Hydrogels ◽  
Cell Behaviors ◽  
Porous Architecture ◽  
In Situ Hydrogel

Injectable hydrogels have been widely applied in the field of regenerative medicine. However, current techniques for injectable hydrogels are facing a challenge when trying to generate a biomimetic, porous architecture that is well-acknowledged to facilitate cell behaviors. In this study, an injectable, interconnected, porous hyaluronic acid (HA) hydrogel based on an in-situ bubble self-generation and entrapment process was developed. Through an amide reaction between HA and cystamine dihydrochloride activated by EDC/NHS, CO2 bubbles were generated and were subsequently entrapped inside the substrate due to a rapid gelation-induced retention effect. HA hydrogels with different molecular weights and concentrations were prepared and the effects of the hydrogel precursor solution’s concentration and viscosity on the properties of hydrogels were investigated. The results showed that HA10-10 (10 wt.%, MW 100,000 Da) and HA20-2.5 (2.5 wt.%, MW 200,000 Da) exhibited desirable gelation and obvious porous structure. Moreover, HA10-10 represented a high elastic modulus (32 kPa). According to the further in vitro and in vivo studies, all the hydrogels prepared in this study show favorable biocompatibility for desirable cell behaviors and mild host response. Overall, such an in-situ hydrogel with a self-forming bubble and entrapment strategy is believed to provide a robust and versatile platform to engineer injectable hydrogels for a variety of applications in tissue engineering, regenerative medicine, and personalized therapeutics.

In situ forming gelatin/hyaluronic acid hydrogel for tissue sealing and hemostasis

2019 ◽  
Vol 108 (3) ◽  
pp. 790-797
Author(s):  
Jing‐Wan Luo ◽  
Chang Liu ◽  
Jing‐Heng Wu ◽  
Dan‐Hui Zhao ◽  
Long‐Xiang Lin ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
In Situ Forming ◽  
Hyaluronic Acid Hydrogel ◽  
Tissue Sealing

Moist-Retaining, Self-Recoverable, Bioadhesive, and Transparent in Situ Forming Hydrogels To Accelerate Wound Healing

2020 ◽  
Vol 12 (2) ◽  
pp. 2023-2038 ◽  
Author(s):  
Jun Li ◽  
Fan Yu ◽  
Gong Chen ◽  
Jia Liu ◽  
Xiao-Long Li ◽  
...  
Keyword(s):  
Wound Healing ◽  
Accelerate Wound Healing ◽  
In Situ Forming ◽  
In Situ Forming Hydrogels

Simultaneous Orthogonal Dual-Click Approach to Tough, in-Situ-Forming Hydrogels for Cell Encapsulation

2015 ◽  
Vol 137 (4) ◽  
pp. 1618-1622 ◽  
Author(s):  
Vinh X. Truong ◽  
Matthew P. Ablett ◽  
Stephen M. Richardson ◽  
Judith A. Hoyland ◽  
Andrew P. Dove
Keyword(s):  
Cell Encapsulation ◽  
In Situ Forming ◽  
In Situ Forming Hydrogels
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