scholarly journals Positively charged, surfactant-free gold nanoparticles for nucleic acid delivery

RSC Advances ◽  
2015 ◽  
Vol 5 (23) ◽  
pp. 17862-17871 ◽  
Author(s):  
Jianfeng Guo ◽  
Mark J. Armstrong ◽  
Caitriona M. O'Driscoll ◽  
Justin D. Holmes ◽  
Kamil Rahme
Keyword(s):  
Gold Nanoparticles ◽  
Nucleic Acid ◽  
Nucleic Acid Delivery ◽  
Free Gold ◽  
Growth Method ◽  
Positively Charged

Synthesis of positively charged, surfactant-free, not cytotoxic 2–200 nm gold nanoparticles in water by seeding growth method; a powerful candidate for nucleic acid delivery application.

scholarly journals Gold Nanoparticles for Nucleic Acid Delivery

2014 ◽  
Vol 22 (6) ◽  
pp. 1075-1083 ◽  
Author(s):  
Ya Ding ◽  
Ziwen Jiang ◽  
Krishnendu Saha ◽  
Chang Soo Kim ◽  
Sung Tae Kim ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Nucleic Acid ◽  
Nucleic Acid Delivery

Non-Viral Nucleic Acid Delivery: Key Challenges and Future Directions

2011 ◽  
Vol 8 (3) ◽  
pp. 235-244 ◽  
Author(s):  
Mahmoud Elsabahy ◽  
Adil Nazarali ◽  
Marianna Foldvari
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acid Delivery ◽  
Viral Nucleic Acid ◽  
Future Directions

Diagnosing Antibiotic Resistance Using Nucleic Acid Enzymes and Gold Nanoparticles

ACS Nano ◽  
2021 ◽  
Author(s):  
Mohamed A. Abdou Mohamed ◽  
Hannah N. Kozlowski ◽  
Jisung Kim ◽  
Kyryl Zagorovsky ◽  
Melinda Kantor ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Antibiotic Resistance ◽  
Nucleic Acid

Charge‐Conversion Strategies for Nucleic Acid Delivery

2021 ◽  
pp. 2011103
Author(s):  
Kingshuk Dutta ◽  
Ritam Das ◽  
Jewel Medeiros ◽  
Pintu Kanjilal ◽  
S. Thayumanavan
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acid Delivery

scholarly journals Synthetic Histidine-Rich Peptides Inhibit Candida Species and Other Fungi In Vitro: Role of Endocytosis and Treatment Implications

2006 ◽  
Vol 50 (8) ◽  
pp. 2797-2805 ◽  
Author(s):  
Jingsong Zhu ◽  
Paul W. Luther ◽  
Qixin Leng ◽  
A. James Mixson
Keyword(s):  
Nucleic Acid ◽  
Antifungal Activity ◽  
Antifungal Agents ◽  
Fungal Growth ◽  
Nucleic Acid Delivery ◽  
Histatin 5 ◽  
Ph Buffering ◽  
Endosomal Acidification

ABSTRACT A family of histidine-rich peptides, histatins, is secreted by the parotid gland in mammals and exhibits marked inhibitory activity against a number of Candida species. We were particularly interested in the mechanism by which histidine-rich peptides inhibit fungal growth, because our laboratory has synthesized a variety of such peptides for drug and nucleic acid delivery. In contrast to naturally occurring peptides that are linear, peptides made on synthesizers can be varied with respect to their degrees of branching. Using this technology, we explored whether histidine-lysine (HK) polymers of different complexities and degrees of branching affect the growth of several species of Candida. Polymers with higher degrees of branching were progressively more effective against Candida albicans, with the four-branched polymer, H2K4b, most effective. Furthermore, H2K4b accumulated efficiently in C. albicans, which may indicate its ability to transport other antifungal agents intracellularly. Although H2K4b had greater antifungal activity than histatin 5, their mechanisms were similar. Toxicity in C. albicans induced by histatin 5 or branched HK peptides was markedly reduced by 4,4′-diisothiocyanato-stilbene-2,2′-disulfonate, an inhibitor of anion channels. We also determined that bafilomycin A1, an inhibitor of endosomal acidification, significantly decreased the antifungal activity of H2K4b. This suggests that the pH-buffering and subsequent endosomal-disrupting properties of histidine-rich peptides have a role in their antifungal activity. Moreover, the ability of the histidine component of these peptides to disrupt endosomes, which allows their escape from the lysosomal pathway, may explain why these peptides are both effective antifungal agents and nucleic acid delivery carriers.

Nucleic acid delivery using magnetic nanoparticles: the Magnetofection™ technology

2011 ◽  
Vol 2 (4) ◽  
pp. 471-482 ◽  
Author(s):  
Nicolas Laurent ◽  
Cédric Sapet ◽  
Loic Le Gourrierec ◽  
Elodie Bertosio ◽  
Olivier Zelphati
Keyword(s):  
Magnetic Nanoparticles ◽  
Nucleic Acid ◽  
Nucleic Acid Delivery

Arginine-rich hydrophobic polyethylenimine: Potent agent with simple components for nucleic acid delivery

2013 ◽  
Vol 60 ◽  
pp. 18-27 ◽  
Author(s):  
Hamideh Parhiz ◽  
Maryam Hashemi ◽  
Arash Hatefi ◽  
Wayne Thomas Shier ◽  
Sara Amel Farzad ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acid Delivery

Nucleic Acid Delivery with Chitosan Hydroxybenzotriazole

2010 ◽  
Vol 20 (3) ◽  
pp. 127-136 ◽  
Author(s):  
Praneet Opanasopit ◽  
Sunee Techaarpornkul ◽  
Theerasak Rojanarata ◽  
Tanasait Ngawhirunpat ◽  
Uracha Ruktanonchai
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acid Delivery
Sign in / Sign up

Export Citation Format

Share Document