Diagnosing Antibiotic Resistance Using Nucleic Acid Enzymes and Gold Nanoparticles

ACS Nano ◽  
2021 ◽  
Author(s):  
Mohamed A. Abdou Mohamed ◽  
Hannah N. Kozlowski ◽  
Jisung Kim ◽  
Kyryl Zagorovsky ◽  
Melinda Kantor ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Antibiotic Resistance ◽  
Nucleic Acid

Synthesis of Stable Peptide Nucleic Acid-Modified Gold Nanoparticles and their Assembly onto Gold Surfaces

2013 ◽  
Vol 52 (15) ◽  
pp. 4217-4220 ◽  
Author(s):  
Philipp Anstaett ◽  
Yuanhui Zheng ◽  
Thibaut Thai ◽  
Alison M. Funston ◽  
Udo Bach ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Nucleic Acid ◽  
Peptide Nucleic Acid ◽  
Gold Surfaces

scholarly journals Positively charged, surfactant-free gold nanoparticles for nucleic acid delivery

RSC Advances ◽  
2015 ◽  
Vol 5 (23) ◽  
pp. 17862-17871 ◽  
Author(s):  
Jianfeng Guo ◽  
Mark J. Armstrong ◽  
Caitriona M. O'Driscoll ◽  
Justin D. Holmes ◽  
Kamil Rahme
Keyword(s):  
Gold Nanoparticles ◽  
Nucleic Acid ◽  
Nucleic Acid Delivery ◽  
Free Gold ◽  
Growth Method ◽  
Positively Charged

Synthesis of positively charged, surfactant-free, not cytotoxic 2–200 nm gold nanoparticles in water by seeding growth method; a powerful candidate for nucleic acid delivery application.

Colorimetric Nucleic Acid Detection Based on Gold Nanoparticles with Branched DNA

NANO ◽  
2020 ◽  
Vol 15 (08) ◽  
pp. 2050110
Author(s):  
Zhikun Zhang ◽  
Xiaojie Ye ◽  
Qingqing Liu ◽  
Cuixia Hu ◽  
Jimmy Yun ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Nucleic Acid ◽  
Genetic Diseases ◽  
Colorimetric Detection ◽  
Nucleic Acid Detection ◽  
Great Promise ◽  
Dna Nanostructures ◽  
Practical Applications ◽  
Branched Dna ◽  
Target Dna

Nucleic acid detection is becoming increasingly important in the diagnostics of genetic diseases for biological analysis. We herein propose gold nanoparticles as probe for colorimetric detection of nucleic acids with branched DNA nanostructures, which enables a novel and simple colorimetric biosensor. In our system, the target DNA specifically triggered two short-chain ssDNA probes to generate branched DNA nanostructures (Y-shape DNA), which prevent AuNPs from aggregation in aqueous NaCl solution. On the contrary, when the target DNA did not exist, gold nanoparticles were unstable and aggregated easily because there is no anti-aggregation function from Y-shape DNA. Sensor response was found to be proportional to the target DNA concentration from 5 to 100[Formula: see text]nM, with detection limits determined as 5[Formula: see text]nM. The developed platform is for colorimetric nucleic acid detection without enzymes, label and modification holds great promise for practical applications.

scholarly journals Rapid label-free visual detection of KRAS mutations using peptide nucleic acid and unmodified gold nanoparticles

RSC Advances ◽  
2017 ◽  
Vol 7 (77) ◽  
pp. 48554-48560 ◽  
Author(s):  
Xihong Zhao ◽  
Chii-Wann Lin
Keyword(s):  
Colorectal Cancer ◽  
Gold Nanoparticles ◽  
Nucleic Acid ◽  
Peptide Nucleic Acid ◽  
Visual Detection ◽  
Label Free ◽  
Kras Mutations

Colorectal cancer (CRC) is among the most commonly diagnosed cancers worldwide.

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