Tough and VEGF-releasing scaffolds composed of artificial silk fibroin mats and a natural acellular matrix

RSC Advances ◽  
2015 ◽  
Vol 5 (22) ◽  
pp. 16748-16758 ◽  
Author(s):  
Zhaobo Li ◽  
Lujie Song ◽  
Xiangyu Huang ◽  
Hongsheng Wang ◽  
Huili Shao ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Silk Fibroin ◽  
Composite Scaffolds ◽  
Cell Compatibility ◽  
Acellular Matrix ◽  
Good Cell

The blend and coaxially electrospun RSF/BAMG composite scaffolds loaded VEGF exhibited good cell compatibility with improved mechanical properties.

Prevascularized bladder acellular matrix hydrogel/silk fibroin composite scaffolds promote the regeneration of urethra in a rabbit model

2018 ◽  
Vol 14 (1) ◽  
pp. 015002 ◽  
Author(s):  
Nailong Cao ◽  
Lujie Song ◽  
Wenjing Liu ◽  
Suna Fan ◽  
Dan Jiang ◽  
...  
Keyword(s):  
Silk Fibroin ◽  
Rabbit Model ◽  
Composite Scaffolds ◽  
Acellular Matrix

Robust silk fibroin/bacterial cellulose nanoribbon composite scaffolds with radial lamellae and intercalation structure for bone regeneration

2017 ◽  
Vol 5 (20) ◽  
pp. 3640-3650 ◽  
Author(s):  
Jian Chen ◽  
Ao Zhuang ◽  
Huili Shao ◽  
Xuechao Hu ◽  
Yaopeng Zhang
Keyword(s):  
Mechanical Properties ◽  
Bone Regeneration ◽  
Bacterial Cellulose ◽  
Silk Fibroin ◽  
Composite Scaffolds ◽  
Biomimetic Scaffolds

Biomimetic scaffolds with a gradient gap distance and robust mechanical properties were prepared using silk fibroin and bacterial cellulose.

Bladder Acellular Matrix Graft Reinforced Silk Fibroin Composite Scaffolds Loaded VEGF with Aligned Electrospun Fibers in Multiple Layers

2015 ◽  
Vol 1 (4) ◽  
pp. 238-246 ◽  
Author(s):  
Zhaobo Li ◽  
Qiangqiang Liu ◽  
Hongsheng Wang ◽  
Lujie Song ◽  
Huili Shao ◽  
...  
Keyword(s):  
Silk Fibroin ◽  
Electrospun Fibers ◽  
Composite Scaffolds ◽  
Acellular Matrix

scholarly journals Anti-Inflammatory Properties of Injectable Betamethasone-Loaded Tyramine-Modified Gellan Gum/Silk Fibroin Hydrogels

Biomolecules ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 1456
Author(s):  
Isabel Matos Oliveira ◽  
Cristiana Gonçalves ◽  
Myeong Eun Shin ◽  
Sumi Lee ◽  
Rui Luis Reis ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Mechanical Properties ◽  
Silk Fibroin ◽  
Therapeutic Efficacy ◽  
Composite Structures ◽  
Gelation Time ◽  
Polymeric Materials ◽  
Gellan Gum ◽  
Traditional Use

Rheumatoid arthritis is a rheumatic disease for which a healing treatment does not presently exist. Silk fibroin has been extensively studied for use in drug delivery systems due to its uniqueness, versatility and strong clinical track record in medicine. However, in general, natural polymeric materials are not mechanically stable enough, and have high rates of biodegradation. Thus, synthetic materials such as gellan gum can be used to produce composite structures with biological signals to promote tissue-specific interactions while providing the desired mechanical properties. In this work, we aimed to produce hydrogels of tyramine-modified gellan gum with silk fibroin (Ty–GG/SF) via horseradish peroxidase (HRP), with encapsulated betamethasone, to improve the biocompatibility and mechanical properties, and further increase therapeutic efficacy to treat rheumatoid arthritis (RA). The Ty–GG/SF hydrogels presented a β-sheet secondary structure, with gelation time around 2–5 min, good resistance to enzymatic degradation, a suitable injectability profile, viscoelastic capacity with a significant solid component and a betamethasone-controlled release profile over time. In vitro studies showed that Ty–GG/SF hydrogels did not produce a deleterious effect on cellular metabolic activity, morphology or proliferation. Furthermore, Ty–GG/SF hydrogels with encapsulated betamethasone revealed greater therapeutic efficacy than the drug applied alone. Therefore, this strategy can provide an improvement in therapeutic efficacy when compared to the traditional use of drugs for the treatment of rheumatoid arthritis.

scholarly journals Is Dialdehyde Chitosan a Good Substance to Modify Physicochemical Properties of Biopolymeric Materials?

2021 ◽  
Vol 22 (7) ◽  
pp. 3391
Author(s):  
Sylwia Grabska-Zielińska ◽  
Alina Sionkowska ◽  
Ewa Olewnik-Kruszkowska ◽  
Katarzyna Reczyńska ◽  
Elżbieta Pamuła
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Physicochemical Properties ◽  
Silk Fibroin ◽  
Three Dimensional ◽  
Microscopy Imaging ◽  
Maximum Deformation ◽  
One Step ◽  
Chitosan Blends ◽  
Fourier Transfer Infrared Spectroscopy

The aim of this work was to compare physicochemical properties of three dimensional scaffolds based on silk fibroin, collagen and chitosan blends, cross-linked with dialdehyde starch (DAS) and dialdehyde chitosan (DAC). DAS was commercially available, while DAC was obtained by one-step synthesis. Structure and physicochemical properties of the materials were characterized using Fourier transfer infrared spectroscopy with attenuated total reflectance device (FTIR-ATR), swelling behavior and water content measurements, porosity and density observations, scanning electron microscopy imaging (SEM), mechanical properties evaluation and thermogravimetric analysis. Metabolic activity with AlamarBlue assay and live/dead fluorescence staining were performed to evaluate the cytocompatibility of the obtained materials with MG-63 osteoblast-like cells. The results showed that the properties of the scaffolds based on silk fibroin, collagen and chitosan can be modified by chemical cross-linking with DAS and DAC. It was found that DAS and DAC have different influence on the properties of biopolymeric scaffolds. Materials cross-linked with DAS were characterized by higher swelling ability (~4000% for DAS cross-linked materials; ~2500% for DAC cross-linked materials), they had lower density (Coll/CTS/30SF scaffold cross-linked with DAS: 21.8 ± 2.4 g/cm3; cross-linked with DAC: 14.6 ± 0.7 g/cm3) and lower mechanical properties (maximum deformation for DAC cross-linked scaffolds was about 69%; for DAS cross-linked scaffolds it was in the range of 12.67 ± 1.51% and 19.83 ± 1.30%) in comparison to materials cross-linked with DAC. Additionally, scaffolds cross-linked with DAS exhibited higher biocompatibility than those cross-linked with DAC. However, the obtained results showed that both types of scaffolds can provide the support required in regenerative medicine and tissue engineering. The scaffolds presented in the present work can be potentially used in bone tissue engineering to facilitate healing of small bone defects.

scholarly journals Investigation of the biological activity, mechanical properties and wound healing application of a novel scaffold based on lignin–agarose hydrogel and silk fibroin embedded zinc chromite nanoparticles

RSC Advances ◽  
2021 ◽  
Vol 11 (29) ◽  
pp. 17914-17923
Author(s):  
Reza Eivazzadeh-Keihan ◽  
Hooman Aghamirza Moghim Aliabadi ◽  
Fateme Radinekiyan ◽  
Mohammad Sobhani ◽  
Farzane khalili ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Wound Healing ◽  
Biological Activity ◽  
Silk Fibroin ◽  
Agarose Hydrogel ◽  
Novel Scaffold ◽  
Fibroin Solution ◽  
Zinc Chromite

Given the important aspects of wound healing approaches, in this work, an innovative biocompatible nanobiocomposite scaffold was designed and prepared based on cross-linked lignin–agarose hydrogel, extracted silk fibroin solution, and zinc chromite (ZnCr2O4) nanoparticles.

Graphene oxide/alginate/silk fibroin composite as a novel bionanostructure with improved blood compatibility, less toxicity and enhanced mechanical properties

2020 ◽  
Vol 248 ◽  
pp. 116802 ◽  
Author(s):  
Reza Eivazzadeh-Keihan ◽  
Fateme Radinekiyan ◽  
Hamid Madanchi ◽  
Hooman Aghamirza Moghim Aliabadi ◽  
Ali Maleki
Keyword(s):  
Mechanical Properties ◽  
Graphene Oxide ◽  
Silk Fibroin ◽  
Blood Compatibility

Antibacterial performance of Berberine loaded carrageenan/konjac glucomannan hydrogels

2021 ◽  
Vol 11 (9) ◽  
pp. 1516-1522
Author(s):  
Lei Jiang ◽  
Qiuxian Chen ◽  
Jia Liu ◽  
Zhongjie Zhu ◽  
Wei Shao
Keyword(s):  
Antibacterial Effect ◽  
Three Dimensional ◽  
Konjac Glucomannan ◽  
High Porosity ◽  
Release Behavior ◽  
Cell Compatibility ◽  
Antibacterial Materials ◽  
Antibacterial Performance ◽  
Dimensional Network ◽  
Good Cell

Carrageenan and konjac glucomannan are non-toxic polysaccharides which have been widely applied in the biomedical fields. Berberine as the antibacterial agent was successfully loaded into carrageenan/konjac glucomannan hydrogels. The Berberine loaded carrageenan/konjac glucomannan dried hydrogels display three-dimensional network structure, good swelling behavior and high porosity. These dried hydrogels also show controlled release behavior of Berberine. A good antibacterial effect towards S. aureus and C. albicans with good cell compatibility is exhibited. Thus, the fabricated Berberine loaded carrageenan/konjac glucomannan dried hydrogels could be considered as novel antibiotic alternative antibacterial materials.

Sign in / Sign up

Export Citation Format

Share Document