scholarly journals Real-time detection of telomerase activity in cancer cells using a label-free electrochemical impedimetric biosensing microchip

RSC Advances ◽  
2014 ◽  
Vol 4 (94) ◽  
pp. 52357-52365 ◽  
Author(s):  
Lisandro Cunci ◽  
Marina Martinez Vargas ◽  
Roman Cunci ◽  
Ramon Gomez-Moreno ◽  
Ivan Perez ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Real Time ◽  
Telomerase Activity ◽  
Label Free ◽  
Real Time Detection ◽  
Impedimetric Biosensor

Impedimetric biosensor microchip for the detection of telomerase activity as a biomarker for cancer.

Label-Free and Regenerable Aptasensor for Real-Time Detection of Cadmium(II) by Dual Polarization Interferometry

2020 ◽  
Vol 92 (14) ◽  
pp. 10007-10015 ◽  
Author(s):  
Yu Xue ◽  
Yu Wang ◽  
Shuang Wang ◽  
Mengxia Yan ◽  
Jianshe Huang ◽  
...  
Keyword(s):  
Real Time ◽  
Label Free ◽  
Dual Polarization ◽  
Polarization Interferometry ◽  
Dual Polarization Interferometry ◽  
Real Time Detection

scholarly journals Detection of Clinical Mesenchymal Cancer Cells from Bladder Wash Urine for Real-Time Detection and Prognosis

Cancers ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 1274 ◽  
Author(s):  
Bee Luan Khoo ◽  
Charlotte Bouquerel ◽  
Pradeep Durai ◽  
Sarannya Anil ◽  
Benjamin Goh ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cancer Cells ◽  
Real Time ◽  
High Efficiency ◽  
Stream Line ◽  
Clinical Samples ◽  
High Recurrence Rate ◽  
Mesenchymal Transition ◽  
Non Invasive ◽  
Real Time Detection

Bladder cancer (BC) is a disease that requires lifelong surveillance due to its high recurrence rate. An efficient method for the non-invasive rapid monitoring of patient prognosis and downstream phenotype characterization is warranted. Here, we develop an integrated procedure to detect aggressive mesenchymal exfoliated bladder cancer cells (EBCCs) from patients in a label-free manner. Using a combination of filtration and inertial focusing principles, the procedure allowed the focusing of EBCCs in a single stream-line for high-throughput separation from other urine components such as large squamous cells and blood cells using a microfluidic sorting device. Characterization of enriched cells can be completed within hours, suggesting a potential utility for real-time detection. We also demonstrate high efficiency of cancer cell recovery (93.3 ± 4.8%) and specific retrieval of various epithelial to mesenchymal transition (EMT) phenotype cell fractions from respective outlets of the microfluidic device. EMT is closely associated with metastasis, drug resistance and tumor-initiating potential. This procedure is validated with clinical samples, and further demonstrate the efficacy of bladder wash procedure to reduce EBCCs counts over time. Overall, the uniqueness of a rapid and non-invasive method permitting the separation of different EMT phenotypes shows high potential for clinical utility. We expect this approach will better facilitate the routine screening procedure in BC and greatly enhance personalized treatment.

Nanophotonics based label free detection mechanism for real-time monitoring of interleukin-6

Nanoscale ◽  
2020 ◽  
Vol 12 (16) ◽  
pp. 9194-9207 ◽  
Author(s):  
Munezza A. Khan ◽  
Mohammad Mujahid ◽  
Say Chye Joachim Loo ◽  
Vidya N. Chamundeswari
Keyword(s):  
Photonic Crystals ◽  
Real Time ◽  
Interleukin 6 ◽  
High Fidelity ◽  
Label Free ◽  
Real Time Monitoring ◽  
Detection Mechanism ◽  
Label Free Detection ◽  
Real Time Detection

Magneto-photonic crystals/MPCs are promising candidates for devising high-fidelity embedded biosensor systems which offer facile & real time detection of diagnostic proteins.

Real-time detection of the interaction between anticancer drug daunorubicin and cancer cells by Au-MCNT nanocomposites modified electrode

2010 ◽  
Vol 40 (6) ◽  
pp. 739-743
Author(s):  
JingYuan LI ◽  
Gang L ◽  
HaiJun ZHANG ◽  
ChangYu WU ◽  
QingNing LI ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Real Time ◽  
Modified Electrode ◽  
Anticancer Drug ◽  
Real Time Detection

Real-time detection of telomerase activity utilizing duplex scorpion primers and hairpin-like reverse primers

2004 ◽  
Vol 28 (12) ◽  
pp. 1488 ◽  
Author(s):  
Yan-Ping Huang ◽  
De-Ming Kong ◽  
Qi-Meng Chen ◽  
Han-Xi Shen ◽  
Huai-Feng Mi
Keyword(s):  
Real Time ◽  
Telomerase Activity ◽  
Real Time Detection
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