Glutathione-triggered release of model drug molecules from mesoporous silica nanoparticles via a non-redox process

RSC Advances ◽  
2015 ◽  
Vol 5 (36) ◽  
pp. 28836-28839 ◽  
Author(s):  
Xiaoxi Huang ◽  
Tao Zhang ◽  
Anandarup Goswami ◽  
Feixiang Luo ◽  
Tewodros Asefa
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Redox Process ◽  
Triggered Release ◽  
Drug Molecules ◽  
Model Drug

Model drug-loaded mesoporous silica nanoparticles (MSNs) that are responsive to the pH rather than the redox changes related to glutathione (GSH) are prepared using surfactant-free MSNs as a precursor.

A microfluidic approach to micromembrane synthesis for complex release profiles of nanocarriers

Lab on a Chip ◽  
2020 ◽  
Vol 20 (6) ◽  
pp. 1066-1071 ◽  
Author(s):  
Nan Jia ◽  
Erica Rosella ◽  
Estelle Juère ◽  
Roxane Pouliot ◽  
Freddy Kleitz ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Triggered Release ◽  
Functionalized Mesoporous Silica ◽  
Physically Crosslinked ◽  
Release Profiles

Physically crosslinked layered microscale biomembranes from pure chitosan are demonstrated for pH-triggered release functionalized mesoporous silica nanoparticles. The work opens the door to synthesis of complex nano-enhanced micro membranes.

Ultra-small mesoporous silica nanoparticles as efficient carriers for pH responsive releases of anti-cancer drugs

2015 ◽  
Vol 44 (46) ◽  
pp. 20186-20192 ◽  
Author(s):  
Haoquan Zheng ◽  
Cheuk-Wai Tai ◽  
Jie Su ◽  
Xiaodong Zou ◽  
Feifei Gao
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Electrostatic Interactions ◽  
Mesoporous Silica Nanoparticles ◽  
Ph Responsive ◽  
Drug Molecule ◽  
Drug Molecules ◽  
Anti Cancer

A pH-responsive drug delivery system via mesoporous silica nanoparticles as carriers can be achieved based on electrostatic interactions between drug molecules and carriers, when the isoelectric point of the drug molecule is high.

scholarly journals Triggered release in lipid bilayer-capped mesoporous silica nanoparticles containing SPION using an alternating magnetic field

2012 ◽  
Vol 48 (45) ◽  
pp. 5647 ◽  
Author(s):  
Eugenio Bringas ◽  
Özcan Köysüren ◽  
Dat V. Quach ◽  
Morteza Mahmoudi ◽  
Elena Aznar ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Lipid Bilayer ◽  
Mesoporous Silica Nanoparticles ◽  
Alternating Magnetic Field ◽  
Triggered Release

Redox-Triggered Release of Moxifloxacin from Mesoporous Silica Nanoparticles Functionalized with Disulfide Snap-Tops Enhances Efficacy Against Pneumonic Tularemia in Mice

Small ◽  
2016 ◽  
Vol 12 (27) ◽  
pp. 3690-3702 ◽  
Author(s):  
Bai-Yu Lee ◽  
Zilu Li ◽  
Daniel L. Clemens ◽  
Barbara Jane Dillon ◽  
Angela A. Hwang ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Triggered Release

scholarly journals Cytostatic and Cytotoxic Effects of Hollow-Shell Mesoporous Silica Nanoparticles Containing Magnetic Iron Oxide

Nanomaterials ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 2455
Author(s):  
Manuel Pérez-Garnes ◽  
Victoria Morales ◽  
Raul Sanz ◽  
Rafael A. García-Muñoz
Keyword(s):  
Iron Oxide ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Loading ◽  
Target Cells ◽  
One Pot ◽  
Hollow Shell ◽  
Magnetic Iron Oxide ◽  
Model Drug

Among the different types of nanoparticles used in biomedical applications, Fe nanoparticles and mesoporous siliceous materials have been extensively investigated because of their possible theranostic applications. Here, we present hollow-shell mesoporous silica nanoparticles that encapsulate iron oxide and that are prepared using a drug-structure-directing agent concept (DSDA), composed of the model drug tryptophan modified by carbon aliphatic hydrocarbon chains. The modified tryptophan can behave as an organic template that allows directing the hollow-shell mesoporous silica framework, as a result of its micellisation and subsequent assembly of the silica around it. The one-pot synthesis procedure facilitates the incorporation of hydrophobically stabilised iron oxide nanoparticles into the hollow internal silica cavities, with the model drug tryptophan in the shell pores, thus enabling the incorporation of different functionalities into the all-in-one nanoparticles named mesoporous silica nanoparticles containing magnetic iron oxide (Fe3O4@MSNs). Additionally, the drug loading capability and the release of tryptophan from the silica nanoparticles were examined, as well as the cytostaticity and cytotoxicity of the Fe3O4@MSNs in different colon cancer cell lines. The results indicate that Fe3O4@MSNs have great potential for drug loading and drug delivery into specific target cells, thereby overcoming the limitations associated with conventional drug formulations, which are unable to selectively reach the sites of interest.

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