pH-sensitive amphiphilic copolymer brush Chol-g-P(HEMA-co-DEAEMA)-b-PPEGMA: synthesis and self-assembled micelles for controlled anti-cancer drug release

RSC Advances ◽  
2014 ◽  
Vol 4 (76) ◽  
pp. 40232-40240 ◽  
Author(s):  
Can Yang Zhang ◽  
Wen Sheng Wu ◽  
Na Yao ◽  
Bin Zhao ◽  
Li Juan Zhang
Keyword(s):  
Drug Release ◽  
Drug Carrier ◽  
Ph Sensitive ◽  
Amphiphilic Copolymer ◽  
Cancer Drug ◽  
Anti Cancer ◽  
Self Assembled ◽  
Copolymer Brush

A novel pH-sensitive amphiphilic copolymer Chol-g-P(HEMA-co-DEAEMA)-b-PPEGMA and its micelles were developed as a promising anti-cancer drug carrier.

pH-Sensitive Micelles Self-Assembled from Amphiphilic Copolymer Brush for Delivery of Poorly Water-Soluble Drugs

2011 ◽  
Vol 12 (1) ◽  
pp. 116-122 ◽  
Author(s):  
You Qiang Yang ◽  
Ling Shan Zheng ◽  
Xin Dong Guo ◽  
Yu Qian ◽  
Li Juan Zhang
Keyword(s):  
Ph Sensitive ◽  
Amphiphilic Copolymer ◽  
Water Soluble ◽  
Poorly Water Soluble Drugs ◽  
Water Soluble Drugs ◽  
Poorly Water Soluble ◽  
Self Assembled ◽  
Copolymer Brush

Amphiphilic copolymer brush with random pH-sensitive/hydrophobic structure: synthesis and self-assembled micelles for sustained drug delivery

Soft Matter ◽  
2012 ◽  
Vol 8 (2) ◽  
pp. 454-464 ◽  
Author(s):  
You Qiang Yang ◽  
Xin Dong Guo ◽  
Wen Jing Lin ◽  
Li Juan Zhang ◽  
Can Yang Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ph Sensitive ◽  
Amphiphilic Copolymer ◽  
Sustained Drug Delivery ◽  
Structure Synthesis ◽  
Self Assembled ◽  
Copolymer Brush

Polymer-Tethered pH-Sensitive Magnetic Nanoparticles for Targeted Delivery of Anti-Cancer Drug

2014 ◽  
Vol 936 ◽  
pp. 723-727
Author(s):  
Yue Qing Shen ◽  
Meng Lu Pu ◽  
Wei Jiang
Keyword(s):  
Targeted Delivery ◽  
Drug Carrier ◽  
Ph Sensitive ◽  
Cancer Drug ◽  
Lysosomal Ph ◽  
Efficient Delivery ◽  
Chemical Grafting ◽  
Anti Cancer ◽  
Ph Sensitive Polymer

Efficient delivery of drug to tumor cells is one of the crucial issues in cancer therapy. This letter addresses for the first time that poly (acrylic acid) (PAA), a pH-sensitive polymer, is tethered to the surface of the nanoparticles by chemical grafting. The release rates of doxorubicin (DOX) are subsequently studied in vitro. The results reveal that DOX can be released preferentially at the desired lysosomal pH, and show that the anti-cancer drug carrier can be applied to the biomedical applications.

Biodegradable pH-sensitive polyurethane micelles with different polyethylene glycol (PEG) locations for anti-cancer drug carrier applications

RSC Advances ◽  
2016 ◽  
Vol 6 (100) ◽  
pp. 97684-97693 ◽  
Author(s):  
Yongchao Yao ◽  
Deqiu Xu ◽  
Chang Liu ◽  
Yayuan Guan ◽  
Jiya Zhang ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Cancer Cells ◽  
Drug Carrier ◽  
Ph Sensitive ◽  
Cancer Drug ◽  
Anti Cancer

Biodegradable pH sensitive polyurethane micelles with a dense brush like coating of PEG were prepared. The PTX-loaded PEG-g-PU-3 micelles exhibited potent cytotoxicity against H460 cancer cells compared to PEG-b-PU-3 and PEG-c-PU-3 micelles.

Self-Assembled Nanocarriers Based on Amphiphilic Natural Polymers for Anti- Cancer Drug Delivery Applications

2018 ◽  
Vol 23 (35) ◽  
Author(s):  
Sally Sabra ◽  
Mona Abdelmoneem ◽  
Mahmoud Abdelwakil ◽  
Moustafa Taha Mabrouk ◽  
Doaa Anwar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Drug ◽  
Natural Polymers ◽  
Anti Cancer ◽  
Drug Delivery Applications ◽  
Self Assembled ◽  
Cancer Drug Delivery

Stereocomplexation Assisted Assembly of Poly(γ-glutamic Acid)-graft-polylactide Nano-micelles and Their Efficacy as Anticancer Drug Carrier

2018 ◽  
Vol 18 (2) ◽  
pp. 302-311
Author(s):  
Shulin Dai ◽  
Yucheng Feng ◽  
Shuyi Li ◽  
Yuxiao Chen ◽  
Meiqing Liu ◽  
...  
Keyword(s):  
Glutamic Acid ◽  
Drug Carrier ◽  
Drug Loading ◽  
Drug Carriers ◽  
Cancer Drug ◽  
Drug Release Profile ◽  
Sustained Drug Release ◽  
Anti Cancer ◽  
Physical Interactions

Background: Micelles as drug carriers are characterized by their inherent instability due to the weak physical interactions that facilitate the self-assembly of amphiphilic block copolymers. As one of the strong physical interactions, the stereocomplexation between the equal molar of enantiomeric polylactides, i.e., the poly(L-lactide) (PLLA) and poly(D-lactide) (PDLA), may be harnessed to obtain micelles with enhanced stability and drug loading capacity and consequent sustained release. </P><P> Aims/Methods: In this paper, stereocomplexed micelles gama-PGA-g-PLA micelles) were fabricated from the stereocomplexation between poly(gama-glutamic acid)-graft-PLLA gama-PGA-g-PLA) and poly(gamaglutamic acid)-graft-PDLA gama-PGA-g-PLA). These stereocomplexed micelles exhibited a lower CMC than the corresponding enantiomeric micelles. Result: Furthermore, they showed higher drug loading content and drug loading efficiency in addition to more sustained drug release profile in vitro. In vivo imaging confirmed that the DiR-encapsulated stereocomplexed gama-PGA-g-PLA micelles can deliver anti-cancer drug to tumors with enhanced tissue penetration. Overall, gama-PGA-g-PLA micelles exhibited greater anti-cancer effects as compared with the free drug and the stereocomplexation may be a promising strategy for fabrication of anti-cancer drug carriers with significantly enhanced efficacy.

Synthesis and characterization of fluorescent chitosan–ZnSe/ZnS nanoparticles for potential drug carriers

RSC Advances ◽  
2015 ◽  
Vol 5 (49) ◽  
pp. 38810-38817 ◽  
Author(s):  
Yeping Li ◽  
Jingbo Xu ◽  
Yun Xu ◽  
Liying Huang ◽  
Junli Wang ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Drug Carrier ◽  
Drug Carriers ◽  
Cancer Drug ◽  
Synthesis And Characterization ◽  
Potential Drug ◽  
Zns Nanoparticles ◽  
New Approach ◽  
Anti Cancer

The objective of the study is to describe a new approach of combining quantum dots into chitosan as an anti-cancer drug carrier.

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