Biodegradable pH-sensitive polyurethane micelles with different polyethylene glycol (PEG) locations for anti-cancer drug carrier applications

RSC Advances ◽  
2016 ◽  
Vol 6 (100) ◽  
pp. 97684-97693 ◽  
Author(s):  
Yongchao Yao ◽  
Deqiu Xu ◽  
Chang Liu ◽  
Yayuan Guan ◽  
Jiya Zhang ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Cancer Cells ◽  
Drug Carrier ◽  
Ph Sensitive ◽  
Cancer Drug ◽  
Anti Cancer

Biodegradable pH sensitive polyurethane micelles with a dense brush like coating of PEG were prepared. The PTX-loaded PEG-g-PU-3 micelles exhibited potent cytotoxicity against H460 cancer cells compared to PEG-b-PU-3 and PEG-c-PU-3 micelles.

scholarly journals Cellular Analysis and Chemotherapeutic Potential of a Bi-Functionalized Halloysite Nanotube

Pharmaceutics ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 962
Author(s):  
Yangyang Luo ◽  
Ahmed Humayun ◽  
Teresa A. Murray ◽  
Benjamin S. Kemp ◽  
Antwine McFarland ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Drug Carrier ◽  
Drug Loading ◽  
Cancer Drug ◽  
Intracellular Location ◽  
Cellular Analysis ◽  
Osteoblast Cell Line ◽  
Wide Range ◽  
Anti Cancer ◽  
Target Cancer

The surface of halloysite nanotubes (HNTs) was bifunctionalized with two ligands—folic acid and a fluorochrome. In tandem, this combination should selectively target cancer cells and provide a means for imaging the nanoparticle. Modified bi-functionalized HNTs (bi-HNTs) were then doped with the anti-cancer drug methotrexate. bi-HNTs were characterized and subjected to in vitro tests to assess cellular growth and changes in cellular behavior in three cell lines—colon cancer, osteosarcoma, and a pre-osteoblast cell line (MC3T3-E1). Cell viability, proliferation, and cell uptake efficiency were assessed. The bi-HNTs showed cytocompatibility at a wide range of concentrations. Compared with regular-sized HNTs, reduced HNTs (~6 microns) were taken up by cells in more significant amounts, but increased cytotoxicity lead to apoptosis. Multi-photon images confirmed the intracellular location of bi-HNTs, and the method of cell entry was mainly through caveolae-mediated endocytosis. The bi-HNTs showed a high drug loading efficiency with methotrexate and a prolonged period of release. Most importantly, bi-HNTs were designed as a drug carrier to target cancer cells specifically, and imaging data shows that non-cancerous cells were unaffected after exposure to MTX-doped bi-HNTs. All data provide support for our nanoparticle design as a mechanism to selectively target cancer cells and significantly reduce the side-effects caused by off-targeting of anti-cancer drugs.

Polymer-Tethered pH-Sensitive Magnetic Nanoparticles for Targeted Delivery of Anti-Cancer Drug

2014 ◽  
Vol 936 ◽  
pp. 723-727
Author(s):  
Yue Qing Shen ◽  
Meng Lu Pu ◽  
Wei Jiang
Keyword(s):  
Targeted Delivery ◽  
Drug Carrier ◽  
Ph Sensitive ◽  
Cancer Drug ◽  
Lysosomal Ph ◽  
Efficient Delivery ◽  
Chemical Grafting ◽  
Anti Cancer ◽  
Ph Sensitive Polymer

Efficient delivery of drug to tumor cells is one of the crucial issues in cancer therapy. This letter addresses for the first time that poly (acrylic acid) (PAA), a pH-sensitive polymer, is tethered to the surface of the nanoparticles by chemical grafting. The release rates of doxorubicin (DOX) are subsequently studied in vitro. The results reveal that DOX can be released preferentially at the desired lysosomal pH, and show that the anti-cancer drug carrier can be applied to the biomedical applications.

pH-sensitive amphiphilic copolymer brush Chol-g-P(HEMA-co-DEAEMA)-b-PPEGMA: synthesis and self-assembled micelles for controlled anti-cancer drug release

RSC Advances ◽  
2014 ◽  
Vol 4 (76) ◽  
pp. 40232-40240 ◽  
Author(s):  
Can Yang Zhang ◽  
Wen Sheng Wu ◽  
Na Yao ◽  
Bin Zhao ◽  
Li Juan Zhang
Keyword(s):  
Drug Release ◽  
Drug Carrier ◽  
Ph Sensitive ◽  
Amphiphilic Copolymer ◽  
Cancer Drug ◽  
Anti Cancer ◽  
Self Assembled ◽  
Copolymer Brush

A novel pH-sensitive amphiphilic copolymer Chol-g-P(HEMA-co-DEAEMA)-b-PPEGMA and its micelles were developed as a promising anti-cancer drug carrier.

Stereocomplexation Assisted Assembly of Poly(γ-glutamic Acid)-graft-polylactide Nano-micelles and Their Efficacy as Anticancer Drug Carrier

2018 ◽  
Vol 18 (2) ◽  
pp. 302-311
Author(s):  
Shulin Dai ◽  
Yucheng Feng ◽  
Shuyi Li ◽  
Yuxiao Chen ◽  
Meiqing Liu ◽  
...  
Keyword(s):  
Glutamic Acid ◽  
Drug Carrier ◽  
Drug Loading ◽  
Drug Carriers ◽  
Cancer Drug ◽  
Drug Release Profile ◽  
Sustained Drug Release ◽  
Anti Cancer ◽  
Physical Interactions

Background: Micelles as drug carriers are characterized by their inherent instability due to the weak physical interactions that facilitate the self-assembly of amphiphilic block copolymers. As one of the strong physical interactions, the stereocomplexation between the equal molar of enantiomeric polylactides, i.e., the poly(L-lactide) (PLLA) and poly(D-lactide) (PDLA), may be harnessed to obtain micelles with enhanced stability and drug loading capacity and consequent sustained release. </P><P> Aims/Methods: In this paper, stereocomplexed micelles gama-PGA-g-PLA micelles) were fabricated from the stereocomplexation between poly(gama-glutamic acid)-graft-PLLA gama-PGA-g-PLA) and poly(gamaglutamic acid)-graft-PDLA gama-PGA-g-PLA). These stereocomplexed micelles exhibited a lower CMC than the corresponding enantiomeric micelles. Result: Furthermore, they showed higher drug loading content and drug loading efficiency in addition to more sustained drug release profile in vitro. In vivo imaging confirmed that the DiR-encapsulated stereocomplexed gama-PGA-g-PLA micelles can deliver anti-cancer drug to tumors with enhanced tissue penetration. Overall, gama-PGA-g-PLA micelles exhibited greater anti-cancer effects as compared with the free drug and the stereocomplexation may be a promising strategy for fabrication of anti-cancer drug carriers with significantly enhanced efficacy.

Synthesis and characterization of fluorescent chitosan–ZnSe/ZnS nanoparticles for potential drug carriers

RSC Advances ◽  
2015 ◽  
Vol 5 (49) ◽  
pp. 38810-38817 ◽  
Author(s):  
Yeping Li ◽  
Jingbo Xu ◽  
Yun Xu ◽  
Liying Huang ◽  
Junli Wang ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Drug Carrier ◽  
Drug Carriers ◽  
Cancer Drug ◽  
Synthesis And Characterization ◽  
Potential Drug ◽  
Zns Nanoparticles ◽  
New Approach ◽  
Anti Cancer

The objective of the study is to describe a new approach of combining quantum dots into chitosan as an anti-cancer drug carrier.

Chondroitin sulfate-curcumin micelle with good stability and reduction sensitivity for anti-cancer drug carrier

2021 ◽  
pp. 130667
Author(s):  
Shao-Fei Zhang ◽  
Wenbin Hu ◽  
Xiang Yan ◽  
Duliu Wang ◽  
Wen Yang ◽  
...  
Keyword(s):  
Chondroitin Sulfate ◽  
Drug Carrier ◽  
Good Stability ◽  
Cancer Drug ◽  
Anti Cancer

Thermosensitive polymer-conjugated albumin nanospheres as thermal targeting anti-cancer drug carrier

2008 ◽  
Vol 35 (4) ◽  
pp. 271-282 ◽  
Author(s):  
Zheyu Shen ◽  
Wei Wei ◽  
Yongjiang Zhao ◽  
Guanghui Ma ◽  
Toshiaki Dobashi ◽  
...  
Keyword(s):  
Drug Carrier ◽  
Cancer Drug ◽  
Thermosensitive Polymer ◽  
Anti Cancer ◽  
Thermal Targeting

Synthesis of Polynucleotide Modified Gold Nanoparticles as a High Potent Anti-Cancer Drug Carrier

2009 ◽  
Vol 56 (4) ◽  
pp. 703-708 ◽  
Author(s):  
Ching-Ming Wu ◽  
Ping-Ching Wu ◽  
Yun-Han Wang ◽  
Tsung-Ju Li ◽  
Li-Xing Yang ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Drug Carrier ◽  
Cancer Drug ◽  
Anti Cancer
Sign in / Sign up

Export Citation Format

Share Document