Amphiphilic copolymer brush with random pH-sensitive/hydrophobic structure: synthesis and self-assembled micelles for sustained drug delivery

Soft Matter ◽  
2012 ◽  
Vol 8 (2) ◽  
pp. 454-464 ◽  
Author(s):  
You Qiang Yang ◽  
Xin Dong Guo ◽  
Wen Jing Lin ◽  
Li Juan Zhang ◽  
Can Yang Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ph Sensitive ◽  
Amphiphilic Copolymer ◽  
Sustained Drug Delivery ◽  
Structure Synthesis ◽  
Self Assembled ◽  
Copolymer Brush

pH-Sensitive Micelles Self-Assembled from Amphiphilic Copolymer Brush for Delivery of Poorly Water-Soluble Drugs

2011 ◽  
Vol 12 (1) ◽  
pp. 116-122 ◽  
Author(s):  
You Qiang Yang ◽  
Ling Shan Zheng ◽  
Xin Dong Guo ◽  
Yu Qian ◽  
Li Juan Zhang
Keyword(s):  
Ph Sensitive ◽  
Amphiphilic Copolymer ◽  
Water Soluble ◽  
Poorly Water Soluble Drugs ◽  
Water Soluble Drugs ◽  
Poorly Water Soluble ◽  
Self Assembled ◽  
Copolymer Brush

pH-sensitive amphiphilic copolymer brush Chol-g-P(HEMA-co-DEAEMA)-b-PPEGMA: synthesis and self-assembled micelles for controlled anti-cancer drug release

RSC Advances ◽  
2014 ◽  
Vol 4 (76) ◽  
pp. 40232-40240 ◽  
Author(s):  
Can Yang Zhang ◽  
Wen Sheng Wu ◽  
Na Yao ◽  
Bin Zhao ◽  
Li Juan Zhang
Keyword(s):  
Drug Release ◽  
Drug Carrier ◽  
Ph Sensitive ◽  
Amphiphilic Copolymer ◽  
Cancer Drug ◽  
Anti Cancer ◽  
Self Assembled ◽  
Copolymer Brush

A novel pH-sensitive amphiphilic copolymer Chol-g-P(HEMA-co-DEAEMA)-b-PPEGMA and its micelles were developed as a promising anti-cancer drug carrier.

scholarly journals PLLA-Grafted Gelatin Amphiphilic Copolymer and Its Self-Assembled Nano Carrier for Anticancer Drug Delivery

2019 ◽  
Vol 220 (5) ◽  
pp. 1800528 ◽  
Author(s):  
Du Beibei ◽  
Fan Tiantang ◽  
Li Jiafeng ◽  
Gong Li ◽  
Zhang Qin ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Amphiphilic Copolymer ◽  
Anticancer Drug Delivery ◽  
Self Assembled

scholarly journals Peptide Nanomaterials for Drug Delivery Applications

2020 ◽  
Vol 21 (4) ◽  
pp. 401-412 ◽  
Author(s):  
Sreekanth Pentlavalli ◽  
Sophie Coulter ◽  
Garry Laverty
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Diverse Range ◽  
Drug Molecules ◽  
Sustained Drug Delivery ◽  
Self Assembling ◽  
Wide Range ◽  
Methods Of Synthesis ◽  
Self Assembled

Self-assembled peptides have been shown to form well-defined nanostructures which display outstanding characteristics for many biomedical applications and especially in controlled drug delivery. Such biomaterials are becoming increasingly popular due to routine, standardized methods of synthesis, high biocompatibility, biodegradability and ease of upscale. Moreover, one can modify the structure at the molecular level to form various nanostructures with a wide range of applications in the field of medicine. Through environmental modifications such as changes in pH and ionic strength and the introduction of enzymes or light, it is possible to trigger self-assembly and design a host of different self-assembled nanostructures. The resulting nanostructures include nanotubes, nanofibers, hydrogels and nanovesicles which all display a diverse range of physico-chemical and mechanical properties. Depending on their design, peptide self-assembling nanostructures can be manufactured with improved biocompatibility and in vivo stability and the ability to encapsulate drugs with the capacity for sustained drug delivery. These molecules can act as carriers for drug molecules to ferry cargo intracellularly and respond to stimuli changes for both hydrophilic and hydrophobic drugs. This review explores the types of self-assembling nanostructures, the effects of external stimuli on and the mechanisms behind the assembly process, and applications for such technology in drug delivery.

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