Catalyst-free synthesis of trisubstituted tetrahydrothiophenes in water via a cascade sulfa-Michael/aldol (Henry) type reaction

RSC Advances ◽  
2014 ◽  
Vol 4 (96) ◽  
pp. 54032-54038 ◽  
Author(s):  
Jian Song ◽  
Jamia Moss ◽  
Da-Cheng Yang ◽  
Zhi Guan ◽  
Yan-Hong He
Keyword(s):  
Type Reaction ◽  
Catalyst Free

ChemInform Abstract: Catalyst-Free Synthesis of Trisubstituted Tetrahydrothiophenes in Water via a Cascade Sulfa-Michael/Aldol (Henry) Type Reaction.

ChemInform ◽  
2015 ◽  
Vol 46 (17) ◽  
pp. no-no
Author(s):  
Jian Song ◽  
Jamia Moss ◽  
Da-Cheng Yang ◽  
Zhi Guan ◽  
Yan-Hong He
Keyword(s):  
Type Reaction ◽  
Catalyst Free

Catalyst-free, Solvent-promoted and Scalable Multicomponent Synthesis of 3-Aminoalkylated Indoles via a Mannich-type Reaction

2014 ◽  
Vol 69 (6) ◽  
pp. 721-727 ◽  
Author(s):  
Jian-Fei Cao ◽  
Yan-Li Chen ◽  
Zhi Guan ◽  
Yan-Hong He
Keyword(s):  
Aromatic Aldehydes ◽  
Secondary Amines ◽  
Multicomponent Synthesis ◽  
Type Reaction ◽  
Catalyst Free

A catalyst-free, solvent-promoted and scalable three-component Mannich-type reaction of indoles, aromatic aldehydes and secondary amines for the synthesis of 3-(1-dialkylaminoalkyl)-1H-indoles has been developed. The protocol provided a mild, simple and highly atom-economic alternative to prepare the title compounds, and the corresponding products could be obtained in good to excellent yields in most cases.

Catalyst-free Synthesis of Betti bases in a Mannich-Type Reaction

2013 ◽  
Vol 2 (5) ◽  
pp. 395-398 ◽  
Author(s):  
Mazaahir Kidwai ◽  
Ritika Chauhan
Keyword(s):  
Type Reaction ◽  
Catalyst Free

ChemInform Abstract: A Catalyst-Free N-H Insertion/Mannich-Type Reaction Cascade of α-Nitrodiazoesters.

ChemInform ◽  
2013 ◽  
Vol 44 (46) ◽  
pp. no-no
Author(s):  
Ting Yang ◽  
Hao Zhuang ◽  
Xichen Lin ◽  
Jia-Ning Xiang ◽  
John D. Elliott ◽  
...  
Keyword(s):  
Type Reaction ◽  
Catalyst Free

ChemInform Abstract: Catalyst-Free Dehydrative SN1-Type Reaction of Indolyl Alcohols with Diverse Nucleophiles “on water”.

ChemInform ◽  
2016 ◽  
Vol 47 (27) ◽  
Author(s):  
Jian Xiao ◽  
Hao Wen ◽  
Liang Wang ◽  
Lubin Xu ◽  
Zhihui Hao ◽  
...  
Keyword(s):  
Type Reaction ◽  
Catalyst Free

scholarly journals Functionalization of N-arylmaleimides by sp3 C–H bonds of hydroacridines(qinolines)

2020 ◽  
pp. 165-170
Author(s):  
N.V. Smetanin ◽  
◽  
A.V. Mazepa ◽  
Keyword(s):  
1H Nmr ◽  
Spectral Methods ◽  
Good Yield ◽  
Single Step ◽  
Main Direction ◽  
Facile Synthesis ◽  
Nmr Spectrum ◽  
Type Reaction ◽  
Catalyst Free ◽  
High Yields

The catalyst-free sp3 C–H functionalization of tetrahydroacridine(quinolines) derivatives has been achieved using a Michael-type reaction with N-arylmaleimides. This method enables the facile synthesis of biologically important N-aryl bearing tetrahydroacridine(quinolines) moieties in a single step with high yields. The reaction occurs under non-catalytic conditions by heating of hydroacridines(quinolines) in DMSO within 4 h at 100–1200C. The reaction between starting compounds allows synthesizing (3S/4R)-3-[(3R/4S)-9-chloroacridine(quinoline)-4-yl]-1(-N-aryl)pyrrolidine-2,5-diones with a good yield. The structure of compounds was proved by spectral methods of analysis. The 1H NMR spectrum shows characteristic signals of protons of the CH-groups in acridine(quinoline) (3.4–3.5 ppm) and pyrrolidine (3.8–3.9 ppm) cycles. It is interesting to note that the main direction of the fragmentation is the Michael retro-reaction, which is accompanied by the elimination of 1-(2-nitrophenyl)-1H-pyrrole-2,5-dione and leads to the formation of m/z ions of starting chloroacridines(quinolines).

Catalyst-free and multicomponent synthesis of 3-aminoalkylated indoles via Mannich-type reaction: multitargeted anticancer, tyrosinase and α-glucosidase inhibitory activities

2021 ◽  
Author(s):  
Dung Thi-Kim Hoang ◽  
Kim-Chi T. Huynh ◽  
Huy Kim-Khanh Ngo ◽  
Phuc Hoang Nguyen ◽  
Khanh Hoai Dang ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Multicomponent Synthesis ◽  
Type Reaction ◽  
Catalyst Free ◽  
Highly Efficient ◽  
Inhibitory Activities

Highly efficient and sustainable approach for the multi-component synthesis of 3-aminoalkylated indoles was investigated via Mannich-type reaction under catalyst-free, methanol and ethylene glycol (EG) as promoting media. Synthesizing various substrates...

A facile synthesis of stable β-amino- N -/ O -hemiacetals through a catalyst-free three-component Mannich-type reaction

2017 ◽  
Vol 58 (15) ◽  
pp. 1490-1494 ◽  
Author(s):  
Rodrigo Abonia ◽  
Juan C. Castillo ◽  
Alexander Garay ◽  
Braulio Insuasty ◽  
Jairo Quiroga ◽  
...  
Keyword(s):  
Facile Synthesis ◽  
Type Reaction ◽  
Catalyst Free
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