scholarly journals Nanostructures by self-assembly of polyglycidol-derivatized lipids

RSC Advances ◽  
2014 ◽  
Vol 4 (70) ◽  
pp. 37208-37219 ◽  
Author(s):  
Pavel Bakardzhiev ◽  
Stanislav Rangelov ◽  
Barbara Trzebicka ◽  
Denitsa Momekova ◽  
Georgi Lalev ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Self Assembly ◽  
Lamellar Structures ◽  
Dilute Aqueous Solution ◽  
Spherical Micelles

Polyglycidol-derivatized lipids were successfully prepared and their self-assembly in dilute aqueous solution into spherical micelles and lamellar structures was investigated.

scholarly journals Self-Assembly of Linear Amphiphilic Pentablock Terpolymer PAAx-PS48-PEO46-PS48-PAAxin Dilute Aqueous Solution

Polymers ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 2183
Author(s):  
Jia Gao ◽  
Kun An ◽  
Chao Lv ◽  
Jingjing Nie ◽  
Junting Xu ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Zeta Potential ◽  
Self Assembly ◽  
Potential Measurement ◽  
Transmission Electron ◽  
Dilute Aqueous Solution ◽  
Dilute Aqueous Solutions ◽  
Poly Ethylene Oxide ◽  
Spherical Micelles ◽  
Poly Ethylene

A series of linear amphiphilic pentablock terpolymer PAAx-b-PS48-b-PEO46-b-PS48-b-PAAx (AxS48O46S48Ax) with various lengths x of the PAA block (x = 15, 40, 60, and 90) were synthesized via a two-step atom transfer radical polymerization (ATRP) using Br-poly(ethylene oxide)-Br (Br-PEO46-Br) as the macroinitiator, styrene (St) as the first monomer, and tert-butyl acrylate (tBA) as the second monomer, followed with the hydrolysis of PtBA blocks. The AxS48O46S48Ax pentablock terpolymers formed micelles in dilute aqueous solution, of which the morphologies were dependent on the length x of the PAA block. Cryogenic transmission electron microscopy (cryo-TEM), dynamic light scattering (DLS), and zeta potential measurement were employed to investigate the morphologies, chain structures, size, and size distribution of the obtained micelles. The morphology of AxS48O46S48Ax micelles changed from spherical vesicles with ordered porous membranes to long double nanotubes, then to long nanotubes with inner modulated nanotubes or short nanotubes, and finally, to spherical micelles or large compound vesicles with spherical micelles inside when x increased from 15 to 90. The hydrophobic PS blocks formed the walls of vesicles and nanotubes as well as the core of spherical micelles. The hydrophilic PEO and PAA block chains were located on the surfaces of vesicle membranes, nanotubes, and spherical micelles. The PAA block chains were partially ionized, leading to the negative zeta potential of AxS48O46S48Ax micelles in dilute aqueous solutions.

scholarly journals Self-assembly of liquid crystal block copolymer PEG-b-smectic polymer in pure state and in dilute aqueous solution

2009 ◽  
Vol 143 ◽  
pp. 235 ◽  
Author(s):  
Bing Xu ◽  
Rafael Piñol ◽  
Merveille Nono-Djamen ◽  
Sandrine Pensec ◽  
Patrick Keller ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Liquid Crystal ◽  
Block Copolymer ◽  
Self Assembly ◽  
Pure State ◽  
Dilute Aqueous Solution ◽  
Crystal Block

Synthesis and Self-Assembly Study of Biodegradable Amphiphilic Triblock Copolymers with PEG Block

2014 ◽  
Vol 998-999 ◽  
pp. 95-98
Author(s):  
Xu Du ◽  
Qin Wang ◽  
Chuan Dong Wang ◽  
Yang Liu
Keyword(s):  
Electron Microscopy ◽  
Aqueous Solution ◽  
Ethylene Glycol ◽  
Self Assembly ◽  
Triblock Copolymers ◽  
Poly Ethylene Glycol ◽  
Chemical Structures ◽  
Transmission Electron ◽  
Spherical Micelles ◽  
Poly Ethylene

Three biodegradable amphiphilic triblock copolymers: polylactide-poly (ethylene glycol)-polylactide (PLA-PEG-PLA), poly (ε-caprolactone)-poly (ethylene glycol)-poly (ε-caprolactone) (PCL-PEG-PCL) and poly (lactide-glycolide)-poly (ethylene glycol)-poly (lactide-glycolide) (PLGA-PEG-PLGA) were synthesized. Their chemical structures were characterized. In aqueous solution, their self-assembly and degradation were studied by dynamic light scattering (DLS) and transmission electron microscopy (TEM). Spherical micelles were formed in aqueous solution via self-assembly of the amphiphilic triblock copolymers. After degradation, the PLA-PEG-PLA and PCL-PEG-PCL micelles became smaller and the PLGA-PEG-PLGA micelles change to vesicles, which should mainly attribute to their different degradation speed.

Self-Assembly of Thermosensitive Amphiphilic Pentablock Terpolymer PNIPAMx-b-PtBA90-b-PPO36-b-PtBA90-b-PNIPAMx in Dilute Aqueous Solution

2018 ◽  
Vol 51 (24) ◽  
pp. 10136-10149 ◽  
Author(s):  
Chao Lv ◽  
Zhijun Zhang ◽  
Jia Gao ◽  
Jinqiao Xue ◽  
Jianyuan Li ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Self Assembly ◽  
Dilute Aqueous Solution

Hydrophobicity and CH/π-interaction-driven self-assembly of amphiphilic aromatic hydrocarbons into nanosheets

2019 ◽  
Vol 55 (99) ◽  
pp. 14950-14953 ◽  
Author(s):  
Tsuyoshi Nishikawa ◽  
Hiroki Narita ◽  
Soichiro Ogi ◽  
Yoshikatsu Sato ◽  
Shigehiro Yamaguchi
Keyword(s):  
Aqueous Solution ◽  
Aromatic Hydrocarbons ◽  
Self Assembly ◽  
Molecular Packing ◽  
Packing Structure ◽  
Dilute Aqueous Solution ◽  
Micrometer Scale

The hydrophobicity and CH/π-interaction-driven self-assembly of an amphiphile that contains a biphenylanthracene group furnishes micrometer-scale nanosheets with a windmill-shaped molecular packing structure in dilute aqueous solution.

Structural characterization of the model amphipathic peptide Ac-LKKLLKLLKKLLKL-NH2 in aqueous solution and with 2,2,2-trifluoroethanol and 1,1,1,3,3,3-hexafluoroisopropanol

2013 ◽  
Vol 91 (6) ◽  
pp. 406-413 ◽  
Author(s):  
Garry W. Buchko ◽  
Avijita Jain ◽  
Matthew L. Reback ◽  
Wendy J. Shaw
Keyword(s):  
Aqueous Solution ◽  
Self Assembly ◽  
Helical Structure ◽  
Cd Spectroscopy ◽  
Size Exclusion ◽  
Amphipathic Peptide ◽  
Amphipathic Peptides ◽  
Fluorinated Alcohols ◽  
Dilute Aqueous Solution

Short-chain amphipathic peptides are promising components in the new generation of engineered biomaterials. The model 14-residue leucine–lysine peptide Ac-LKKLLKLLKKLLKL-NH2 (LKα) is one such amphipathic peptide. In dilute aqueous solution (<0.05 mmol/L), it was previously proposed, using CD spectroscopic data, that LKα existed in a cooperative monomeric (unstructured) – tetrameric (α-helical) equilibrium that shifted towards the tetramer at high NaCl and peptide concentrations. Here, at similar peptide concentrations, CD spectroscopy shows that LKα readily adopts α-helical structure in the presence of 2,2,2-trifluoroethanol (TFE) and 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) with maximal helical character in 20% TFE and ∼10% HFIP (v/v). The helical character in fluorinated alcohols suggested by the CD data at low peptide concentrations (0.06 mmol/L) is corroborated at high peptide concentrations (1.5 mmol/L) by NMR NOE data that also show that 1.5 mmol/L LKα is helical in 100% water. Size exclusion chromatography and estimations of rotational correlation times (τc) showed that the self-assembled LKα complexes contained three to five peptides. Removing the N-terminal acetyl group prevents LKα from forming helices and self-associating at high NaCl and peptide concentrations. This more detailed characterization of the structural and physical properties of LKα over a greater range of peptide concentrations and in the presence of fluorinated alcohols will assist the design of biomaterials containing amphipathic peptides and guide the ability to control self-assembly.

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