Controlled one-pot synthesis of pH-sensitive self-assembled diblock copolymers and their aggregation behavior

Polymer ◽  
2005 ◽  
Vol 46 (23) ◽  
pp. 10045-10055 ◽  
Author(s):  
B.W. Mao ◽  
L.H. Gan ◽  
Y.Y. Gan ◽  
K.C. Tam ◽  
O.K. Tan
2021 ◽  
Vol 23 (3) ◽  
pp. 1248-1258
Author(s):  
Shannon M. North ◽  
Steven P. Armes

An atom-efficient, wholly aqueous one-pot synthesis of zwitterionic diblock copolymers has been devised. Such copolymers can serve as highly effective aqueous dispersants for nano-sized transparent yellow iron oxide particles.


RSC Advances ◽  
2018 ◽  
Vol 8 (65) ◽  
pp. 37433-37440 ◽  
Author(s):  
Huicong Zhang ◽  
Xuandong Wang ◽  
Peiyuan Wang ◽  
Rong Liu ◽  
Xuemei Hou ◽  
...  

Polydopamine-doped mesoporous silica nanocomposites (PMSNs) were controllably synthesized by a one-pot approach. They were demonstrated to be good biodegradability, pH-responsive drug release and targeting synergistic chemo-photothermal therapy.


2020 ◽  
Vol 8 (46) ◽  
pp. 10540-10548
Author(s):  
Na Zhou ◽  
Ning Zhang ◽  
Zhe Zhi ◽  
Xunan Jing ◽  
Daomeng Liu ◽  
...  

In order to improve the therapeutic efficacy and reduce the side effects of anticancer drugs, pH sensitive and biodegradable polyphosphazene prodrugs were prepared.


2008 ◽  
Vol 128 (12) ◽  
pp. 1980-1984 ◽  
Author(s):  
M. Marandi ◽  
N. Taghavinia ◽  
A. Iraji zad ◽  
S.M. Mahdavi

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Ming Wang ◽  
Meiling Huang ◽  
Jianting Wang ◽  
Mingquan Ye ◽  
Yan Deng ◽  
...  

The self-assembled folate-biotin-pullulan (FBP) nanoparticles (NPs) were prepared by facile one-pot synthesis and their physicochemical properties were characterized. The self-assembled FBP NPs were used as an anticancer drug nanocarrier entrapping doxorubicin (DOX) for targeting folate-receptors-overexpressing cancer cells. The identification of prepared NPs to folate-receptor-expressing cancer cells (KB cells) was affirmed by cell viability measurement, folate competition test, and flow cytometric analysis. Compared with the naked DOX and DOX/BP NPs, the DOX/FBP NPs had lower IC50value compared to KB cells as a result of the folate-receptor-mediated endocytosis process. The cytotoxicity of DOX/FBP NPs to KB cells could be inhibited competitively by free folate. The cellular intake pattern of naked DOX and drug-loaded NPs was identified by confocal laser scanning microscopy (CLSM) observation and the higher cellular uptake of drug for DOX/FBP NPs over naked DOX was observed. The prepared FBP NPs had the potential to be used as a powerful carrier to target anticancer drugs to folate-receptor-expressing tumor cells and reduce cytotoxicity to normal tissues.


2014 ◽  
Vol 39 ◽  
pp. 75-78 ◽  
Author(s):  
Sreenivasulu Bandi ◽  
Niladri Bihari Debata ◽  
Venkatachalam Ramkumar ◽  
Dillip Kumar Chand

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