Injectable hydrogels with in situ-forming hydrophobic domains: oligo(d,l-lactide) modified poly(oligoethylene glycol methacrylate) hydrogels

2014 ◽  
Vol 5 (23) ◽  
pp. 6811-6823 ◽  
Author(s):  
Niels M. B. Smeets ◽  
Mathew Patenaude ◽  
Dennis Kinio ◽  
Francis M. Yavitt ◽  
Emilia Bakaic ◽  
...  
Keyword(s):  
Injectable Hydrogels ◽  
Glycol Methacrylate ◽  
In Situ Forming ◽  
Oligoethylene Glycol

Injectable hydrogels based on poly(ethylene glycol) and derivatives as functional biomaterials

RSC Advances ◽  
2015 ◽  
Vol 5 (45) ◽  
pp. 35469-35486 ◽  
Author(s):  
Emilia Bakaic ◽  
Niels M. B. Smeets ◽  
Todd Hoare
Keyword(s):  
Ethylene Glycol ◽  
Recent Progress ◽  
Design Criteria ◽  
Poly Ethylene Glycol ◽  
Injectable Hydrogels ◽  
Glycol Methacrylate ◽  
Oligoethylene Glycol ◽  
Poly Ethylene ◽  
Functional Biomaterials

The design criteria for injectable, in situ-gelling hydrogels are reviewed in conjunction with highlights on recent progress in the preparation of injectable PEG and PEG-analogue poly(oligoethylene glycol methacrylate) (POEGMA) hydrogels.

In situ forming oxidized salecan/gelatin injectable hydrogels for vancomycin delivery and 3D cell culture

2020 ◽  
Vol 31 (6) ◽  
pp. 762-780 ◽  
Author(s):  
Zhiping Fan ◽  
Ping Cheng ◽  
Gaowei Yin ◽  
Zhengping Wang ◽  
Jun Han
Keyword(s):  
Cell Culture ◽  
3D Cell Culture ◽  
Injectable Hydrogels ◽  
In Situ Forming

scholarly journals In Situ-Forming Cellulose/Albumin-Based Injectable Hydrogels for Localized Antitumor Therapy

Polymers ◽  
2021 ◽  
Vol 13 (23) ◽  
pp. 4221
Author(s):  
Ying Chen ◽  
Xiaomin Wang ◽  
Yudong Huang ◽  
Peipei Kuang ◽  
Yushu Wang ◽  
...  
Keyword(s):  
Ex Vivo ◽  
Antitumor Therapy ◽  
Injectable Hydrogels ◽  
External Temperature ◽  
Minimal Invasiveness ◽  
In Situ Forming ◽  
External Stimuli

Injectable hydrogels, which are formed in situ by changing the external stimuli, have the unique characteristics of easy handling and minimal invasiveness, thus providing the advantage of bypass surgical operation and improving patient compliance. Using external temperature stimuli to realize the sol-to-gel transition when preparing injectable hydrogel is essential since the temperature is stable in vivo and controllable during ex vivo, although the hydrogels obtained possibly have low mechanical strength and stability. In this work, we designed an in situ fast-forming injectable cellulose/albumin-based hydrogel (HPC-g-AA/BSA hydrogels) that responded to body temperature and which was a well-stabilized hydrogen-bonding network, effectively solving the problem of poor mechanical properties. The application of localized delivery of chemotherapeutic drugs of HPC-g-AA/BSA hydrogels was evaluated. In vitro and in vivo results show that HPC-g-AA/BSA hydrogels exhibited higher antitumor efficacy of reducing tumor size and seem ideal for localized antitumor therapy.

scholarly journals Injectable in situ forming hydrogels based on natural and synthetic polymers for potential application in cartilage repair

RSC Advances ◽  
2015 ◽  
Vol 5 (25) ◽  
pp. 19715-19723 ◽  
Author(s):  
Calogero Fiorica ◽  
Fabio Salvatore Palumbo ◽  
Giovanna Pitarresi ◽  
Alessandro Gulino ◽  
Stefano Agnello ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Cartilage Repair ◽  
Potential Application ◽  
Synthetic Polymers ◽  
Injectable Hydrogels ◽  
In Situ Forming ◽  
In Situ Forming Hydrogels ◽  
Natural And Synthetic

Injectable hydrogels based on hyaluronic acid, elastin and a biocompatible polyaspartamide are optimal scaffolds of viable chondrocytes for potential cartilage repair.

scholarly journals In situ forming injectable hydrogels for drug delivery and wound repair

2018 ◽  
Vol 127 ◽  
pp. 167-184 ◽  
Author(s):  
Robert Dimatteo ◽  
Nicole J. Darling ◽  
Tatiana Segura
Keyword(s):  
Drug Delivery ◽  
Wound Repair ◽  
Injectable Hydrogels ◽  
In Situ Forming

In situ-forming injectable hydrogels for regenerative medicine

2014 ◽  
Vol 39 (12) ◽  
pp. 1973-1986 ◽  
Author(s):  
Jeong-A. Yang ◽  
Junseok Yeom ◽  
Byung Woo Hwang ◽  
Allan S. Hoffman ◽  
Sei Kwang Hahn
Keyword(s):  
Regenerative Medicine ◽  
Injectable Hydrogels ◽  
In Situ Forming

Injectable in-situ Forming Depot Of Doxycycline Hyclate/α-Cyclodextrin Complex using PLGA for Periodontitis Treatment: Preparation, Charac-terization, and In-Vitro Evaluation

2020 ◽  
Vol 17 ◽  
Author(s):  
Elham Khodaverdi ◽  
Farhad Eisvand ◽  
Mohammad Sina Nezami ◽  
Seyedeh Nesa Rezaeian Shiadeh ◽  
Hossein Kamali ◽  
...  
Keyword(s):  
Complex Form ◽  
Docking Studies ◽  
Morphological Properties ◽  
Burst Release ◽  
Cyclodextrin Complex ◽  
Doxycycline Hyclate ◽  
Scanning Calorimetry ◽  
In Situ Forming

Background:: Doxycycline (DOX) is used in treating a bacterial infection, especially for periodontitis treatment. Objective: To reduce irritation of DOX for subgingival administration and increase the chemical stability and against enzy-matic, the complex of α-cyclodextrin with DOX was prepared and loaded into injectable in situ forming implant based on PLGA. Methods:: FTIR, molecular docking studies, X-ray diffraction, and differential scanning calorimetry was performed to char-acterize the DOX/α-cyclodextrin complex. Finally, the in-vitro drug release and modeling, morphological properties, and cellular cytotoxic effects were also evaluated. Results:: The stability of DOX was improved with complex than pure DOX. The main advantage of the complex is the al-most complete release (96.31 ± 2.56 %) of the drug within 14 days of the implant, whereas in the formulation containing the pure DOX and the physical mixture the DOX with α-cyclodextrin release is reached to 70.18 ± 3.61 % and 77.03 ± 3.56 %, respectively. This trend is due to elevate of DOX stability in the DOX/ α-cyclodextrin complex form within PLGA implant that confirmed by the results of stability. Conclusion:: Our results were indicative that the formulation containing DOX/α-cyclodextrin complex was biocompatible and sustained-release with minimum initial burst release.

Enhanced drug loading of in situ forming gels for oral mucositis pain control

2021 ◽  
Vol 595 ◽  
pp. 120225
Author(s):  
Tingting Li ◽  
Rajesh V. Lalla ◽  
Diane J. Burgess
Keyword(s):  
Oral Mucositis ◽  
Pain Control ◽  
Drug Loading ◽  
In Situ Forming
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