Biostable and bioreducible polymersomes for intracellular delivery of doxorubicin

2014 ◽  
Vol 5 (16) ◽  
pp. 4627-4634 ◽  
Author(s):  
Thavasyappan Thambi ◽  
V. G. Deepagan ◽  
Hyewon Ko ◽  
Yung Doug Suh ◽  
Gi-Ra Yi ◽  
...  
Keyword(s):  
Drug Release ◽  
Cancer Cells ◽  
Intracellular Delivery

To minimize the premature drug release of nanocarriers, we have developed chemically cross-linked bioreducible polymersomes (CLPMs) that can specifically release the drug inside cancer cells.

The Improvement of Paclitaxel Cytotoxicity using Nanocellulose based Nature Resources

2019 ◽  
Vol 1 (1) ◽  
pp. 7
Author(s):  
R Nahrowi ◽  
A Setiawan ◽  
Noviany Noviany ◽  
I Sukmana ◽  
S D Yuwono
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Natural Resources ◽  
Cell Viability ◽  
Cancer Cells ◽  
Drug Delivery System ◽  
Target Cell ◽  
Mitotic Cycle ◽  
Potential Sources ◽  
Local Accumulation

Paclitaxel is one of the cancer drugs that often used. These drug kills cancer cells byinhibiting mitotic cycle. The efficiency of paclitaxel is increased by the use ofnanomaterials as a carrier of paclitaxel. Nanomaterials can enhance encapsulationefficiency, improve the drug release to the target cell following nanomaterialdegradation, and improve local accumulation of drug in the cell through endocytosisreceptor. Nanomaterial that often used forencapsulation of paclitaxel is a polymerderived from natural resources such as cellulose. The advantages of cellulose as acarrier of paclitaxel are nontoxic, biodegradable, and very abundant from varioussources. One of the potential sources of cellulose for drug delivery system is cassavabaggase.Keywords: Paclitaxel, encapsulation, cell viability, nanocellulose

scholarly journals Photo-Responsive Supramolecular Micelles for Controlled Drug Release and Improved Chemotherapy

2020 ◽  
Vol 22 (1) ◽  
pp. 154
Author(s):  
Fasih Bintang Ilhami ◽  
Kai-Chen Peng ◽  
Yi-Shiuan Chang ◽  
Yihalem Abebe Alemayehu ◽  
Hsieh-Chih Tsai ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Drug Release ◽  
Visible Light ◽  
Cancer Cells ◽  
Laser Irradiation ◽  
Reactive Oxygen ◽  
Controlled Drug Release ◽  
Grand Challenge ◽  
Supramolecular System ◽  
Oxygen Species

Development of stimuli-responsive supramolecular micelles that enable high levels of well-controlled drug release in cancer cells remains a grand challenge. Here, we encapsulated the antitumor drug doxorubicin (DOX) and pro-photosensitizer 5-aminolevulinic acid (5-ALA) within adenine-functionalized supramolecular micelles (A-PPG), in order to achieve effective drug delivery combined with photo-chemotherapy. The resulting DOX/5-ALA-loaded micelles exhibited excellent light and pH-responsive behavior in aqueous solution and high drug-entrapment stability in serum-rich media. A short duration (1–2 min) of laser irradiation with visible light induced the dissociation of the DOX/5-ALA complexes within the micelles, which disrupted micellular stability and resulted in rapid, immediate release of the physically entrapped drug from the micelles. In addition, in vitro assays of cellular reactive oxygen species generation and cellular internalization confirmed the drug-loaded micelles exhibited significantly enhanced cellular uptake after visible light irradiation, and that the light-triggered disassembly of micellar structures rapidly increased the production of reactive oxygen species within the cells. Importantly, flow cytometric analysis demonstrated that laser irradiation of cancer cells incubated with DOX/5-ALA-loaded A-PPG micelles effectively induced apoptotic cell death via endocytosis. Thus, this newly developed supramolecular system may offer a potential route towards improving the efficacy of synergistic chemotherapeutic approaches for cancer.

Controllable assembly/disassembly of polyphenol-DNA nanocomplex for cascade-responsive drug release in cancer cells

Biomaterials ◽  
2021 ◽  
Vol 273 ◽  
pp. 120846
Author(s):  
Jinpeng Han ◽  
Yuchen Cui ◽  
Zi Gu ◽  
Dayong Yang
Keyword(s):  
Drug Release ◽  
Cancer Cells

scholarly journals Cholesterol Levels Affect the Performance of AuNPs-Decorated Thermo-Sensitive Liposomes as Nanocarriers for Controlled Doxorubicin Delivery

Pharmaceutics ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 973
Author(s):  
Mónica C. García ◽  
Nabila Naitlho ◽  
José Manuel Calderón-Montaño ◽  
Estrella Drago ◽  
Manuela Rueda ◽  
...  
Keyword(s):  
Drug Release ◽  
Cancer Cells ◽  
Electrostatic Interactions ◽  
Drug Loading ◽  
Gradient Methods ◽  
Spherical Shape ◽  
Morphological Properties ◽  
Ovarian Cancer Cells ◽  
Cholesterol Levels ◽  
L1 And L2

Stimulus-responsive liposomes (L) for triggering drug release to the target site are particularly useful in cancer therapy. This research was focused on the evaluation of the effects of cholesterol levels in the performance of gold nanoparticles (AuNPs)-functionalized L for controlled doxorubicin (D) delivery. Their interfacial and morphological properties, drug release behavior against temperature changes and cytotoxic activity against breast and ovarian cancer cells were studied. Langmuir isotherms were performed to identify the most stable combination of lipid components. Two mole fractions of cholesterol (3.35 mol% and 40 mol%, L1 and L2 series, respectively) were evaluated. Thin-film hydration and transmembrane pH-gradient methods were used for preparing the L and for D loading, respectively. The cationic surface of L allowed the anchoring of negatively charged AuNPs by electrostatic interactions, even inducing a shift in the zeta potential of the L2 series. L exhibited nanometric sizes and spherical shape. The higher the proportion of cholesterol, the higher the drug loading. D was released in a controlled manner by diffusion-controlled mechanisms, and the proportions of cholesterol and temperature of release media influenced its release profiles. D-encapsulated L preserved its antiproliferative activity against cancer cells. The developed liposomal formulations exhibit promising properties for cancer treatment and potential for hyperthermia therapy.

Lipo-Poly(L-histidine) Hybrid Materials with pH-Sensitivity, Intracellular Delivery Efficiency, and Intrinsic Targetability to Cancer Cells

2014 ◽  
Vol 35 (9) ◽  
pp. 888-894 ◽  
Author(s):  
Renjith P. Johnson ◽  
Young-Il Jeong ◽  
Johnson V. John ◽  
Chung-Wook Chung ◽  
Seon Hee Choi ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Hybrid Materials ◽  
Intracellular Delivery ◽  
Ph Sensitivity ◽  
Delivery Efficiency

A DT-diaphorase responsive theranostic prodrug for diagnosis, drug release monitoring and therapy

2015 ◽  
Vol 51 (46) ◽  
pp. 9567-9570 ◽  
Author(s):  
Peilian Liu ◽  
Jiangsheng Xu ◽  
Donghang Yan ◽  
Peisheng Zhang ◽  
Fang Zeng ◽  
...  
Keyword(s):  
Drug Release ◽  
Cancer Cells ◽  
Dt Diaphorase

A DT-diaphorase responsive theranostic prodrug has been developed for diagnosis, tracking of drug release and selectively killing cancer cells over-expressed with DT-diaphorase.

Reversibly cross-linked poly(ethylene glycol)–poly(amino acid)s copolymer micelles: a promising approach to overcome the extracellular stability versus intracellular drug release challenge

RSC Advances ◽  
2015 ◽  
Vol 5 (26) ◽  
pp. 20025-20034 ◽  
Author(s):  
Yuling Li ◽  
Sai Wang ◽  
Dandan Zhu ◽  
Yuling Shen ◽  
Baixiang Du ◽  
...  
Keyword(s):  
Amino Acid ◽  
Drug Release ◽  
Ethylene Glycol ◽  
Lipoic Acid ◽  
Triblock Copolymer ◽  
Intracellular Delivery ◽  
Poly Ethylene Glycol ◽  
Copolymer Micelles ◽  
Poly Ethylene ◽  
Copolymer Poly

Reversibly shell cross-linked micelles based on a lipoic acid (LA) decorated triblock copolymer poly(ethylene glycol)-b-poly(γ-benzyl-l-glutamate)-b-poly(l-phenylalanine) have been developed for efficient intracellular delivery of DOX.

scholarly journals Controlled drug release to cancer cells from modular one-photon visible light-responsive micellar system

2016 ◽  
Vol 52 (69) ◽  
pp. 10525-10528 ◽  
Author(s):  
Saemi O. Poelma ◽  
Seung Soo Oh ◽  
Sameh Helmy ◽  
Abigail S. Knight ◽  
G. Leslie Burnett ◽  
...  
Keyword(s):  
Drug Release ◽  
Visible Light ◽  
Small Molecules ◽  
Cancer Cells ◽  
Controlled Drug Release ◽  
Micellar System ◽  
On Demand ◽  
System P

We present a one-photon visible light-responsive micellar system for efficient, on-demand delivery of small molecules.

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