Lipo-Poly(L-histidine) Hybrid Materials with pH-Sensitivity, Intracellular Delivery Efficiency, and Intrinsic Targetability to Cancer Cells

2014 ◽  
Vol 35 (9) ◽  
pp. 888-894 ◽  
Author(s):  
Renjith P. Johnson ◽  
Young-Il Jeong ◽  
Johnson V. John ◽  
Chung-Wook Chung ◽  
Seon Hee Choi ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Hybrid Materials ◽  
Intracellular Delivery ◽  
Ph Sensitivity ◽  
Delivery Efficiency

Engineered Histidine-Enriched Facial Lipopeptides for Enhanced Intracellular Delivery of Functional siRNA to Triple Negative Breast Cancer Cells

2019 ◽  
Vol 11 (5) ◽  
pp. 4719-4736 ◽  
Author(s):  
Abhijit Biswas ◽  
Kasturee Chakraborty ◽  
Chiranjit Dutta ◽  
Sanchita Mukherjee ◽  
Paramita Gayen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Triple Negative Breast Cancer ◽  
Breast Cancer Cells ◽  
Triple Negative ◽  
Intracellular Delivery

pH- and GSH-Sensitive Hyaluronic Acid-MP Conjugate Micelles for Intracellular Delivery of Doxorubicin to Colon Cancer Cells and Cancer Stem Cells

2018 ◽  
Vol 19 (9) ◽  
pp. 3725-3737 ◽  
Author(s):  
Tilahun Ayane Debele ◽  
Lu-Yi Yu ◽  
Cheng-Sheng Yang ◽  
Yao-An Shen ◽  
Chun-Liang Lo
Keyword(s):  
Stem Cells ◽  
Colon Cancer ◽  
Hyaluronic Acid ◽  
Cancer Stem Cells ◽  
Cancer Cells ◽  
Intracellular Delivery ◽  
Colon Cancer Cells

A Facile Approach for Synthesis and Intracellular Delivery of Size Tunable Cationic Peptide Functionalized Gold Nanohybrids in Cancer Cells

2018 ◽  
Vol 29 (4) ◽  
pp. 1102-1110 ◽  
Author(s):  
Kavita Bansal ◽  
Mohammad Aqdas ◽  
Munish Kumar ◽  
Rajni Bala ◽  
Sanpreet Singh ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Intracellular Delivery ◽  
Cationic Peptide

scholarly journals Intracellular delivery of NF-κB small interfering RNA for modulating therapeutic activities of classical anti-cancer drugs in human cervical cancer cells

2013 ◽  
Vol 3 (1) ◽  
pp. 7 ◽  
Author(s):  
Anthony Stanislaus ◽  
Anil Philip Kunnath ◽  
Snigdha Tiash ◽  
Tahereh Fatemian ◽  
Nur Izyani Kamaruzman ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Cells ◽  
Intracellular Delivery ◽  
Cyclin B1 ◽  
Carbonate Apatite ◽  
Cancer Drugs ◽  
Small Interfering Rnas ◽  
Strong Electrostatic Interaction ◽  
Anti Cancer ◽  
Gene Transcripts

Cervical cancer is the second most common cancer and fourth leading cause of cancer-related deaths among women. Advanced stage of the disease is treated with radiation therapy and chemotherapy with poor therapeutic outcome and adverse side effects. NFκB, a well-known transcription factor in the control of immunity and inflammation, has recently emerged as a key regulator of cell survival through induction of antiapoptotic genes. Many human cancers, including cervical carcinoma, constitutively express NF-κB and a blockade in expression of its subunit proteins through targeted knockdown of the gene transcripts with small interfering RNAs (siRNA) could be an attractive approach in order to sensitize the cancer cells towards the widely used anti-cancer drugs. However, the inefficiency of the naked siRNA to cross the plasma membrane and its sensitiveness to nuclease-mediated degradation are the major challenges limiting the siRNA technology in therapeutic intervention. pH-sensitive carbonate apatite has been established as an efficient nano-carrier for intracellular delivery of siRNA, due to its strong electrostatic interaction with the siRNA, the desirable size distribution of the resulting siRNA complex for effective endocytosis and the ability of the endocytosed siRNA to be released from the degradable particles and escape the endosomes, thus leading to the effective knockdown of the target gene of cyclin B1 or ABCB1. Here, we report that carbonate apatite-facilitated delivery of the siRNA targeting NF-κB1 and NF-κB2 gene transcripts in HeLa, a human cervical adenocar- cinoma cell line expressing NF-κB, led to a synergistic effect in enhancement of chemosensitivity to doxorubicin, but apparently not to cisplatin or paclitaxel.

Intracellular Delivery of Recombinant Arginine Deiminase (rADI) by Heparin-Binding Hemagglutinin Adhesion Peptide Restores Sensitivity in rADI-Resistant Cancer Cells

2014 ◽  
Vol 11 (8) ◽  
pp. 2777-2786 ◽  
Author(s):  
Fe-Lin Lin Wu ◽  
Tzyy-Harn Yeh ◽  
Ying-Luen Chen ◽  
Yu-Chin Chiu ◽  
Ju-Chen Cheng ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Intracellular Delivery ◽  
Arginine Deiminase ◽  
Heparin Binding

Biostable and bioreducible polymersomes for intracellular delivery of doxorubicin

2014 ◽  
Vol 5 (16) ◽  
pp. 4627-4634 ◽  
Author(s):  
Thavasyappan Thambi ◽  
V. G. Deepagan ◽  
Hyewon Ko ◽  
Yung Doug Suh ◽  
Gi-Ra Yi ◽  
...  
Keyword(s):  
Drug Release ◽  
Cancer Cells ◽  
Intracellular Delivery

To minimize the premature drug release of nanocarriers, we have developed chemically cross-linked bioreducible polymersomes (CLPMs) that can specifically release the drug inside cancer cells.

Targeted phase-change contrast agents for intracellular delivery to breast cancer tumors: An In vitro study in MDA-MB-231 breast cancer cells

2016 ◽  
Vol 140 (4) ◽  
pp. 3371-3371
Author(s):  
Kyle P. Hadinger ◽  
Joseph P. Marshalek ◽  
Paul S. Sheeran ◽  
Pier Ingram ◽  
Russell S. Witte ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Phase Change ◽  
Contrast Agents ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
In Vitro Study ◽  
Intracellular Delivery ◽  
Vitro Study
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