An intracellularly activatable, fluorogenic probe for cancer imaging

2014 ◽  
Vol 12 (29) ◽  
pp. 5365-5374 ◽  
Author(s):  
Ruisong Tian ◽  
Mingjie Li ◽  
Jin Wang ◽  
Min Yu ◽  
Xiuqi Kong ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Cancer Imaging ◽  
Dual Functional ◽  
Fluorogenic Probe

A newly designed, dual-functional probe based on intracellular activation has been successfully developed for the detection of cancer cells.

scholarly journals Utilizing Edible Agar as a Carrier for Dual Functional Doxorubicin-Fe3O4 Nanotherapy Drugs

Materials ◽  
2021 ◽  
Vol 14 (8) ◽  
pp. 1824
Author(s):  
Yu-Jyuan Wang ◽  
Pei-Ying Lin ◽  
Shu-Ling Hsieh ◽  
Rajendranath Kirankumar ◽  
Hsin-Yi Lin ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Drug Carrier ◽  
Fluorescent Microscopy ◽  
Controlled Drug Release ◽  
Human Colon ◽  
Multiple Drug ◽  
Human Colon Cancer ◽  
Dual Functional ◽  
Heating Capacity ◽  
Short Period

The purpose of this study was to use agar as a multifunctional encapsulating material to allow drug and ferromagnetism to be jointly delivered in one nanoparticle. We successfully encapsulated both Fe3O4 and doxorubicin (DOX) with agar as the drug carrier to obtain DOX-Fe3O4@agar. The iron oxide nanoparticles encapsulated in the carrier maintained good saturation of magnetization (41.9 emu/g) and had superparamagnetism. The heating capacity test showed that the specific absorption rate (SAR) value was 18.9 ± 0.5 W/g, indicating that the ferromagnetic nanoparticles encapsulated in the gel still maintained good heating capacity. Moreover, the magnetocaloric temperature could reach 43 °C in a short period of five minutes. In addition, DOX-Fe3O4@agar reached a maximum release rate of 85% ± 3% in 56 min under a neutral pH 7.0 to simulate the intestinal environment. We found using fluorescent microscopy that DOX entered HT-29 human colon cancer cells and reduced cell viability by 66%. When hyperthermia was induced with an auxiliary external magnetic field, cancer cells could be further killed, with a viability of only 15.4%. These results show that agar is an efficient multiple-drug carrier, and allows controlled drug release. Thus, this synergic treatment has potential application value for biopharmaceutical carrier materials.

A dual functional fluorogenic probe for visualization of intracellular pH and formaldehyde with distinct fluorescence signals

2018 ◽  
Vol 16 (25) ◽  
pp. 4628-4632 ◽  
Author(s):  
Zhenda Xie ◽  
Biao Yin ◽  
Jiajie Shen ◽  
Danqi Hong ◽  
Liquan Zhu ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Intracellular Ph ◽  
Dual Functional ◽  
Fluorogenic Probe

We present a dual functional fluorescent probe (DPFP) for imaging pH and formaldehyde (FA) with distinct fluorescence signals.

Hybrid 3,4-dihydropyrimidin-2-(thi)ones as dual-functional bioactive molecules: fluorescent probes and cytotoxic agents to cancer cells

2020 ◽  
Vol 44 (29) ◽  
pp. 12440-12451 ◽  
Author(s):  
Vanessa P. de Souza ◽  
Fabiano S. Santos ◽  
Fabiano S. Rodembusch ◽  
Carolyne B. Braga ◽  
Catia Ornelas ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Fluorescent Probes ◽  
Cytotoxic Agents ◽  
Bioactive Molecules ◽  
Dual Functional ◽  
Biginelli Compounds

A series of new hybrid fluorescent Biginelli compounds, including a Monastrol derivative, were designed and synthesized with good yields.

scholarly journals Probing biotin receptors in cancer cells with rationally designed fluorogenic squaraine dimers

2020 ◽  
Vol 11 (31) ◽  
pp. 8240-8248 ◽  
Author(s):  
Kyong T. Fam ◽  
Mayeul Collot ◽  
Andrey S. Klymchenko
Keyword(s):  
Cancer Cells ◽  
Rational Design ◽  
Fluorogenic Probe ◽  
Cancerous Cells

Rational design of self-quenched squaraine dimers bearing biotin yielded a bright fluorogenic probe that can distinguish cancerous from non-cancerous cells.

scholarly journals Dual-Functional, Receptor-Targeted Fluorogenic Probe for In Vivo Imaging of Extracellular Protease Expressions

2011 ◽  
Vol 22 (6) ◽  
pp. 1001-1005 ◽  
Author(s):  
Lei Zhu ◽  
Jin Xie ◽  
Magdalena Swierczewska ◽  
Fan Zhang ◽  
Xin Lin ◽  
...  
Keyword(s):  
In Vivo Imaging ◽  
Extracellular Protease ◽  
Dual Functional ◽  
Fluorogenic Probe ◽  
Functional Receptor

scholarly journals Structure-guided discovery of a luminescent theranostic toolkit for living cancer cells and the imaging behavior effect

2020 ◽  
Vol 11 (42) ◽  
pp. 11404-11412 ◽  
Author(s):  
Chun Wu ◽  
Ke-Jia Wu ◽  
Jin-Biao Liu ◽  
Wanhe Wang ◽  
Chung-Hang Leung ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Living Systems ◽  
Guided Discovery ◽  
Dual Functional ◽  
Complex Precursor

In order to optimise dual-functional theranostics for application in living systems, we developed an iridium(iii) theranostic by grafting an inhibitor as a “binding unit” onto an iridium(iii) complex precursor as a “signaling unit”.

Dual-functional supramolecular nanohybrids of quantum dot/biopolymer/chemotherapeutic drug for bioimaging and killing brain cancer cells in vitro

2019 ◽  
Vol 184 ◽  
pp. 110507 ◽  
Author(s):  
Alexandra A.P. Mansur ◽  
Anderson J. Caires ◽  
Sandhra M. Carvalho ◽  
Nadia S.V. Capanema ◽  
Isadora C. Carvalho ◽  
...  
Keyword(s):  
Quantum Dot ◽  
Cancer Cells ◽  
Brain Cancer ◽  
Chemotherapeutic Drug ◽  
Dual Functional

A dual functional liposome specifically targets melanoma cells through integrin and ephrin receptors

RSC Advances ◽  
2016 ◽  
Vol 6 (114) ◽  
pp. 113487-113491 ◽  
Author(s):  
Debmalya Bhunia ◽  
Abhijit Saha ◽  
Anindyasundar Adak ◽  
Gaurav Das ◽  
Surajit Ghosh
Keyword(s):  
Cancer Cells ◽  
Melanoma Cells ◽  
Melanoma Cancer ◽  
Dual Functional ◽  
Ephrin Receptors

A novel bi-functional liposome delivers docetaxel specifically to melanoma cancer cells targeting integrin (α4β1) and ephrin (EphA2) receptors and enhances the efficacy of docetaxel.

Mitochondrial Specific H2Sn Fluorogenic Probe for Live Cell Imaging by Rational Utilization of a Dual-Functional-Photocage Group

ACS Sensors ◽  
2018 ◽  
Vol 3 (9) ◽  
pp. 1622-1626 ◽  
Author(s):  
Linqi Han ◽  
Riri Shi ◽  
Chenqi Xin ◽  
Qiaoqiao Ci ◽  
Jingyan Ge ◽  
...  
Keyword(s):  
Live Cell Imaging ◽  
Cell Imaging ◽  
Live Cell ◽  
Rational Utilization ◽  
Dual Functional ◽  
Fluorogenic Probe
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