scholarly journals Structure-guided discovery of a luminescent theranostic toolkit for living cancer cells and the imaging behavior effect

2020 ◽  
Vol 11 (42) ◽  
pp. 11404-11412 ◽  
Author(s):  
Chun Wu ◽  
Ke-Jia Wu ◽  
Jin-Biao Liu ◽  
Wanhe Wang ◽  
Chung-Hang Leung ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Living Systems ◽  
Guided Discovery ◽  
Dual Functional ◽  
Complex Precursor

In order to optimise dual-functional theranostics for application in living systems, we developed an iridium(iii) theranostic by grafting an inhibitor as a “binding unit” onto an iridium(iii) complex precursor as a “signaling unit”.

scholarly journals Utilizing Edible Agar as a Carrier for Dual Functional Doxorubicin-Fe3O4 Nanotherapy Drugs

Materials ◽  
2021 ◽  
Vol 14 (8) ◽  
pp. 1824
Author(s):  
Yu-Jyuan Wang ◽  
Pei-Ying Lin ◽  
Shu-Ling Hsieh ◽  
Rajendranath Kirankumar ◽  
Hsin-Yi Lin ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Drug Carrier ◽  
Fluorescent Microscopy ◽  
Controlled Drug Release ◽  
Human Colon ◽  
Multiple Drug ◽  
Human Colon Cancer ◽  
Dual Functional ◽  
Heating Capacity ◽  
Short Period

The purpose of this study was to use agar as a multifunctional encapsulating material to allow drug and ferromagnetism to be jointly delivered in one nanoparticle. We successfully encapsulated both Fe3O4 and doxorubicin (DOX) with agar as the drug carrier to obtain DOX-Fe3O4@agar. The iron oxide nanoparticles encapsulated in the carrier maintained good saturation of magnetization (41.9 emu/g) and had superparamagnetism. The heating capacity test showed that the specific absorption rate (SAR) value was 18.9 ± 0.5 W/g, indicating that the ferromagnetic nanoparticles encapsulated in the gel still maintained good heating capacity. Moreover, the magnetocaloric temperature could reach 43 °C in a short period of five minutes. In addition, DOX-Fe3O4@agar reached a maximum release rate of 85% ± 3% in 56 min under a neutral pH 7.0 to simulate the intestinal environment. We found using fluorescent microscopy that DOX entered HT-29 human colon cancer cells and reduced cell viability by 66%. When hyperthermia was induced with an auxiliary external magnetic field, cancer cells could be further killed, with a viability of only 15.4%. These results show that agar is an efficient multiple-drug carrier, and allows controlled drug release. Thus, this synergic treatment has potential application value for biopharmaceutical carrier materials.

Hybrid 3,4-dihydropyrimidin-2-(thi)ones as dual-functional bioactive molecules: fluorescent probes and cytotoxic agents to cancer cells

2020 ◽  
Vol 44 (29) ◽  
pp. 12440-12451 ◽  
Author(s):  
Vanessa P. de Souza ◽  
Fabiano S. Santos ◽  
Fabiano S. Rodembusch ◽  
Carolyne B. Braga ◽  
Catia Ornelas ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Fluorescent Probes ◽  
Cytotoxic Agents ◽  
Bioactive Molecules ◽  
Dual Functional ◽  
Biginelli Compounds

A series of new hybrid fluorescent Biginelli compounds, including a Monastrol derivative, were designed and synthesized with good yields.

Dual-functional supramolecular nanohybrids of quantum dot/biopolymer/chemotherapeutic drug for bioimaging and killing brain cancer cells in vitro

2019 ◽  
Vol 184 ◽  
pp. 110507 ◽  
Author(s):  
Alexandra A.P. Mansur ◽  
Anderson J. Caires ◽  
Sandhra M. Carvalho ◽  
Nadia S.V. Capanema ◽  
Isadora C. Carvalho ◽  
...  
Keyword(s):  
Quantum Dot ◽  
Cancer Cells ◽  
Brain Cancer ◽  
Chemotherapeutic Drug ◽  
Dual Functional

A dual functional liposome specifically targets melanoma cells through integrin and ephrin receptors

RSC Advances ◽  
2016 ◽  
Vol 6 (114) ◽  
pp. 113487-113491 ◽  
Author(s):  
Debmalya Bhunia ◽  
Abhijit Saha ◽  
Anindyasundar Adak ◽  
Gaurav Das ◽  
Surajit Ghosh
Keyword(s):  
Cancer Cells ◽  
Melanoma Cells ◽  
Melanoma Cancer ◽  
Dual Functional ◽  
Ephrin Receptors

A novel bi-functional liposome delivers docetaxel specifically to melanoma cancer cells targeting integrin (α4β1) and ephrin (EphA2) receptors and enhances the efficacy of docetaxel.

An intracellularly activatable, fluorogenic probe for cancer imaging

2014 ◽  
Vol 12 (29) ◽  
pp. 5365-5374 ◽  
Author(s):  
Ruisong Tian ◽  
Mingjie Li ◽  
Jin Wang ◽  
Min Yu ◽  
Xiuqi Kong ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Cancer Imaging ◽  
Dual Functional ◽  
Fluorogenic Probe

A newly designed, dual-functional probe based on intracellular activation has been successfully developed for the detection of cancer cells.

scholarly journals A dual-functional lanthanide nanoprobe for both living cell imaging and ICP-MS quantification of active protease

2016 ◽  
Vol 7 (3) ◽  
pp. 2246-2250 ◽  
Author(s):  
Duan Feng ◽  
Fang Tian ◽  
Weijie Qin ◽  
Xiaohong Qian
Keyword(s):  
Cancer Cells ◽  
Living Cell ◽  
Caspase 3 ◽  
Cell Imaging ◽  
Dual Functional ◽  
Icp Ms ◽  
Active Protease ◽  
Living Cell Imaging

A novel nanoprobe is successfully developed for simultaneous living cell imaging and sensitive quantification of caspase-3 in cancer cells.

scholarly journals Lipid-Based Nanovectors for Targeting of CD44-Overexpressing Tumor Cells

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Silvia Arpicco ◽  
Giuseppe De Rosa ◽  
Elias Fattal
Keyword(s):  
Extracellular Matrix ◽  
Hyaluronic Acid ◽  
Cancer Cells ◽  
Tumor Cells ◽  
Delivery Systems ◽  
Living Systems ◽  
Active Targeting ◽  
Acid Receptor ◽  
Naturally Occurring ◽  
Low Levels

Hyaluronic acid (HA) is a naturally occurring glycosaminoglycan that exists in living systems, and it is a major component of the extracellular matrix. The hyaluronic acid receptor CD44 is found at low levels on the surface of epithelial, haematopoietic, and neuronal cells and is overexpressed in many cancer cells particularly in tumour initiating cells. HA has been therefore used as ligand attached to HA-lipid-based nanovectors for the active targeting of small or large active molecules for the treatment of cancer. This paper describes the different approaches employed for the preparation, characterization, and evaluation of these potent delivery systems.

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