scholarly journals Magnetic nanoparticle-based therapeutic agents for thermo-chemotherapy treatment of cancer

Nanoscale ◽  
2014 ◽  
Vol 6 (20) ◽  
pp. 11553-11573 ◽  
Author(s):  
Aziliz Hervault ◽  
Nguyễn Thị Kim Thanh
Keyword(s):  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Synergistic Effect ◽  
Cancer Treatment ◽  
Magnetic Nanoparticle ◽  
Therapeutic Agents ◽  
Chemotherapy Treatment

Magnetic nanoparticles have great potential as mediators of localised heat as well as vehicles for drug delivery to have synergistic effect of thermo-chemotherapy for cancer treatment.

scholarly journals Magnetic nanoparticle-conjugated polymeric micelles for combined hyperthermia and chemotherapy

Nanoscale ◽  
2015 ◽  
Vol 7 (39) ◽  
pp. 16470-16480 ◽  
Author(s):  
Hyun-Chul Kim ◽  
Eunjoo Kim ◽  
Sang Won Jeong ◽  
Tae-Lin Ha ◽  
Sang-Im Park ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Magnetic Nanoparticles ◽  
Synergistic Effect ◽  
Cancer Cells ◽  
Anticancer Drug ◽  
Magnetic Nanoparticle ◽  
Polymeric Micelles ◽  
Alternating Magnetic Field ◽  
Rapid Release

The cytotoxicity of magnetic nanoparticles-conjugated polymeric micelles encapsulated with an anticancer drug on cancer cells was enhanced by the synergistic effect of heat and the rapid release of the drug under an alternating magnetic field.

Theranostic Nanoparticles for Pancreatic Cancer Treatment

2020 ◽  
Vol 20 ◽  
Author(s):  
LR Jaidev ◽  
Laxmi Shanthi Chede ◽  
Hemanth Kumar Kandikattu
Keyword(s):  
Drug Delivery ◽  
Pancreatic Cancer ◽  
Mortality Rate ◽  
Cancer Treatment ◽  
High Mortality ◽  
Therapeutic Agents ◽  
Present Review ◽  
Survival Period ◽  
New Novel ◽  
Theranostic Nanoparticles

: Pancreatic cancer is one of the low vascular permeable tumors with a high mortality rate. The five-year survival period is ~5%. The field of drug delivery is at its pace in developing unique drug delivery carriers to treat high mortality rate cancers such as pancreatic cancer. Theranostic nanoparticles are the new novel delivery carriers where the carrier is loaded with both diagnostic and therapeutic agents. The present review discusses various therapeutic and theranostic nanocarriers for pancreatic cancer.

IRON OXIDE MAGNETIC NANOPARTICLES AS DRUG DELIVERY SYSTEMS FOR BRAIN CANCER TREATMENT

2021 ◽  
Vol 2 (1) ◽  
pp. 55-66
Author(s):  
Oana Stefana Purcaru ◽  
Alexandra Costachi ◽  
Catalina Elena Cioc ◽  
Alice Buteica ◽  
Anica Dricu
Keyword(s):  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Cancer Treatment ◽  
Targeted Delivery ◽  
Drug Delivery Systems ◽  
High Grade Glioma ◽  
Delivery Systems ◽  
Cancer Drug ◽  
Vitro Effect

Nanotechnology offers a new horizon for cancer drug administration and systemic safety of oncological treatments. Compared with conventional pharmaceutical forms, nanoparticles (NPs) have many advantages such as larger surface, ability to adsorb and targeted delivery of different types of drugs, providing decreased side effects and a patient customed approach in cancer treatment. Due to their diverse chemical composition, NPs offer the possibility of developing innovative therapies, which may be also applied in glioblastoma treatment. Fe3O4 magnetic nanoparticles (MNPs) have been previously used in cancer treatment, as targeted drug delivery systems. Helianthin is an azo dye compound that we found to induce cell death in high grade glioma (HGG) cells. In this study, we analyzed the in vitro effect of MNPs loaded with Helianthin (HeMNPs) on a glioblastoma cell line (GB2B).

Preparation and Characterization of Fe3O4 Magnetic Nanoparticles Labeled with Technetium-99m Pertectnetate

2013 ◽  
Vol 459 ◽  
pp. 51-59 ◽  
Author(s):  
Chang Shu Tsai ◽  
Wei Chung Liu ◽  
Hong Yi Chen ◽  
Wei Chun Hsu
Keyword(s):  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Targeted Drug Delivery ◽  
Magnetic Nanoparticle ◽  
Drug Carrier ◽  
Precipitation Method ◽  
Technetium 99M ◽  
Reducing Ability ◽  
Targeted Drug

In the aspect of biomedical diagnosis, magnetic nanoparticle can be used as drug carrier and MRI/ SPECT/ PET contrast agents. Magnetic fluid hyperthermia is one of the most important cancer therapies. Magnetic nanoparticles display their unique features as heating mediators for hyperthermia. In this study, Fe3O4magnetic nanoparticle was prepared by using chemical co-precipitation method. Tc-99m pertechnetate with Fe3O4magnetic nanoparticles is prepared by using magnet adsorption method. An attempt was also made to evaluate the application in the field of magnetic targeted drug delivery and radioactive targeted cancer treatment in the future. In this work, preparation and characterization of non-polymer and polymer (dextran) coated Fe3O4magnetic nanoparticles labeled with technetium-99m pertectnetate were evaluated and served as precursors study. The Tc-99m labeling efficiency of in-house Fe3O4magnetic nanoparticles (MNP) and commercial kit were ca.98.4 % and 85% (n=5), under the same conc. of 6mM, 0.1 ml of SnCl2·2H2O, respectively. The Tc-99m labeling efficiency of magnetic nanoparticles with its dextran-coated was ca. 58.2% (n=5) at the same conc. and volume of SnCl2·2H2O. The in-vitro stabilities of the 3 kinds of magnetite magnetic fluids were higher than 96.0% (n=5) during 2 hours. The reducing agent of SnCl2·2H2O plays a key role due to its reducing ability for Tc-99m pertechnetate. The optimal reaction time of SnCl2·2H2O with Tc-99m is better under 1 hour. In conclusion, the Fe3O4magnetic nanoparticle labeled with Tc-99m pertechnetate has shown good qualities for its labeling efficiency and stability. It may be feasible preliminary to utilize in the application of magnetic targeted drug delivery of bio-medicine.

Multifunctional Magnetic Nanoparticles for Synergistic Enhancement of Cancer Treatment by Combinatorial Radio Frequency Thermolysis and Drug Delivery

2012 ◽  
Vol 1 (4) ◽  
pp. 493-501 ◽  
Author(s):  
Yang Xu ◽  
Alokita Karmakar ◽  
Wolf E. Heberlein ◽  
Thikra Mustafa ◽  
Alexandru R. Biris ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Radio Frequency ◽  
Cancer Treatment ◽  
Synergistic Enhancement

scholarly journals Applications of Thermoresponsive Magnetic Nanoparticles

2015 ◽  
Vol 2015 ◽  
pp. 1-12 ◽  
Author(s):  
Ibrahim Yildiz ◽  
Banu Sizirici Yildiz
Keyword(s):  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Magnetic Separation ◽  
Magnetic Nanoparticle ◽  
Magnetic Particles ◽  
Polymeric Coatings ◽  
Biomedical Sciences ◽  
Comprehensive Review ◽  
Material Sciences ◽  
Number Of Publications

In recent years, magnetic nanoparticles carrying thermoresponsive polymeric coatings have gained increasing attention in material sciences due to the fact that resultant platforms offer controllable modalities such as imaging, drug delivery, and magnetic separation. As a result, novel materials including biosensors, therapeutic platforms, imaging agents, and magnetic separators have been realized. Since the number of publications reporting the applications of thermoresponsive magnetic nanoparticle has increased steadily over the years, a comprehensive review will be beneficial. In this paper, we aim to review publications studying applications of thermoresponsive nanoparticles in biomedical sciences as well as in environmental and chemical sciences. The paper also briefly discusses chemical formulations, characterizations, and properties of the thermoresponsive magnetic particles and then provides future outlooks.

scholarly journals An overview and bibliometric analysis on the colorectal cancer therapy by magnetic functionalized nanoparticles for the responsive and targeted drug delivery

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Mahdieh Darroudi ◽  
Mehrdad Gholami ◽  
Majid Rezayi ◽  
Majid Khazaei
Keyword(s):  
Magnetic Field ◽  
Colorectal Cancer ◽  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Cancer Therapy ◽  
Cancer Treatment ◽  
High Performance ◽  
Future Research ◽  
General View ◽  
Research Perspective

AbstractWith the growing demands for personalized medicine and medical devices, nanomedicine is a modern scientific field, and research continues to apply nanomaterials for therapeutic and damaged tissue diagnosis. In this regard, substantial progress has been made in synthesizing magnetic nanoparticles with desired sizes, chemical composition, morphologies, and surface chemistry. Among these materials, nanomagnetic iron oxides have demonstrated promise as unique drug delivery carriers due to cancer treatment. This carrier could lead to responsive properties to a specific trigger, including heat, pH, alternative magnetic field, or even enzymes, through functionalization and coating of magnetic nanoparticles, along with biocompatibility, good chemical stability, easy functionalization, simple processing, and ability to localize to the tumor site with the assistance of external magnetic field. Current studies have focused on magnetic nanoparticles’ utilities in cancer therapy, especially for colorectal cancer. Additionally, a bibliometric investigation was performed on the public trends in the field of the magnetic nanoparticle to drug delivery and anticancer, which represented progressing applications of these carriers in the multidisciplinary zones with a general view on future research and identified potential opportunities and challenges. Furthermore, we outline the current challenges and forthcoming research perspective for high performance and fostering advanced MNPs in colorectal cancer treatment. Graphical Abstract

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