scholarly journals Targeted tumor drug delivery and magnetic hyperthermia for cancer treatment by chemotherapeutic-conjugated magnetic nanoparticles

2018 ◽  
Author(s):  
Enrico Catalano
Keyword(s):  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Cancer Treatment ◽  
Magnetic Hyperthermia ◽  
Tumor Drug Delivery

scholarly journals Nanoformulation Design Including MamC-Mediated Biomimetic Nanoparticles Allows the Simultaneous Application of Targeted Drug Delivery and Magnetic Hyperthermia

Polymers ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 1832 ◽  
Author(s):  
Ylenia Jabalera ◽  
Francesca Oltolina ◽  
Ana Peigneux ◽  
Alberto Sola-Leyva ◽  
Maria P. Carrasco-Jiménez ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Targeted Drug Delivery ◽  
Magnetic Hyperthermia ◽  
Simultaneous Application ◽  
Biomimetic Nanoparticles ◽  
Targeted Drug ◽  
Model Drug ◽  
Drug Nanocarriers

The design of novel nanomaterials that can be used as multifunctional platforms allowing the combination of therapies is gaining increased interest. Moreover, if this nanomaterial is intended for a targeted drug delivery, the use of several guidance methods to increase guidance efficiency is also crucial. Magnetic nanoparticles (MNPs) allow this combination of therapies and guidance strategies. In fact, MNPs can be used simultaneously as drug nanocarriers and magnetic hyperthermia agents and, moreover, they can be guided toward the target by an external magnetic field and by their functionalization with a specific probe. However, it is difficult to find a system based on MNPs that exhibits optimal conditions as a drug nanocarrier and as a magnetic hyperthermia agent. In this work, a novel nanoformulation is proposed to be used as a multifunctional platform that also allows dual complementary guidance. This nanoformulation is based on mixtures of inorganic magnetic nanoparticles (M) that have been shown to be optimal hyperthermia agents, and biomimetic magnetic nanoparticles (BM), that have been shown to be highly efficient drug nanocarriers. The presence of the magnetosome protein MamC at the surface of BM confers novel surface properties that allow for the efficient and stable functionalization of these nanoparticles without the need of further coating, with the release of the relevant molecule being pH-dependent, improved by magnetic hyperthermia. The BM are functionalized with Doxorubicin (DOXO) as a model drug and with an antibody that allows for dual guidance based on a magnetic field and on an antibody. The present study represents a proof of concept to optimize the nanoformulation composition in order to provide the best performance in terms of the magnetic hyperthermia agent and drug nanocarrier.

IRON OXIDE MAGNETIC NANOPARTICLES AS DRUG DELIVERY SYSTEMS FOR BRAIN CANCER TREATMENT

2021 ◽  
Vol 2 (1) ◽  
pp. 55-66
Author(s):  
Oana Stefana Purcaru ◽  
Alexandra Costachi ◽  
Catalina Elena Cioc ◽  
Alice Buteica ◽  
Anica Dricu
Keyword(s):  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Cancer Treatment ◽  
Targeted Delivery ◽  
Drug Delivery Systems ◽  
High Grade Glioma ◽  
Delivery Systems ◽  
Cancer Drug ◽  
Vitro Effect

Nanotechnology offers a new horizon for cancer drug administration and systemic safety of oncological treatments. Compared with conventional pharmaceutical forms, nanoparticles (NPs) have many advantages such as larger surface, ability to adsorb and targeted delivery of different types of drugs, providing decreased side effects and a patient customed approach in cancer treatment. Due to their diverse chemical composition, NPs offer the possibility of developing innovative therapies, which may be also applied in glioblastoma treatment. Fe3O4 magnetic nanoparticles (MNPs) have been previously used in cancer treatment, as targeted drug delivery systems. Helianthin is an azo dye compound that we found to induce cell death in high grade glioma (HGG) cells. In this study, we analyzed the in vitro effect of MNPs loaded with Helianthin (HeMNPs) on a glioblastoma cell line (GB2B).

Multifunctional Magnetic Nanoparticles for Synergistic Enhancement of Cancer Treatment by Combinatorial Radio Frequency Thermolysis and Drug Delivery

2012 ◽  
Vol 1 (4) ◽  
pp. 493-501 ◽  
Author(s):  
Yang Xu ◽  
Alokita Karmakar ◽  
Wolf E. Heberlein ◽  
Thikra Mustafa ◽  
Alexandru R. Biris ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Radio Frequency ◽  
Cancer Treatment ◽  
Synergistic Enhancement

Magnetic Nanoparticles for Magnetic Hyperthermia and Controlled Drug Delivery

2014 ◽  
pp. 139-172 ◽  
Author(s):  
Pablo Guardia ◽  
Andreas Riedinger ◽  
Hamilton Kakwere ◽  
Florence Gazeau ◽  
Teresa Pellegrino
Keyword(s):  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Controlled Drug Delivery ◽  
Magnetic Hyperthermia

Magnetic Nanoparticles for Cancer Treatment Using Magnetic Hyperthermia

2018 ◽  
pp. 305-318
Author(s):  
Laura Asín ◽  
Grazyna Stepien ◽  
María Moros ◽  
Raluca Maria Fratila ◽  
Jesús Martínez de la Fuente
Keyword(s):  
Magnetic Nanoparticles ◽  
Cancer Treatment ◽  
Magnetic Hyperthermia

scholarly journals An overview and bibliometric analysis on the colorectal cancer therapy by magnetic functionalized nanoparticles for the responsive and targeted drug delivery

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Mahdieh Darroudi ◽  
Mehrdad Gholami ◽  
Majid Rezayi ◽  
Majid Khazaei
Keyword(s):  
Magnetic Field ◽  
Colorectal Cancer ◽  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Cancer Therapy ◽  
Cancer Treatment ◽  
High Performance ◽  
Future Research ◽  
General View ◽  
Research Perspective

AbstractWith the growing demands for personalized medicine and medical devices, nanomedicine is a modern scientific field, and research continues to apply nanomaterials for therapeutic and damaged tissue diagnosis. In this regard, substantial progress has been made in synthesizing magnetic nanoparticles with desired sizes, chemical composition, morphologies, and surface chemistry. Among these materials, nanomagnetic iron oxides have demonstrated promise as unique drug delivery carriers due to cancer treatment. This carrier could lead to responsive properties to a specific trigger, including heat, pH, alternative magnetic field, or even enzymes, through functionalization and coating of magnetic nanoparticles, along with biocompatibility, good chemical stability, easy functionalization, simple processing, and ability to localize to the tumor site with the assistance of external magnetic field. Current studies have focused on magnetic nanoparticles’ utilities in cancer therapy, especially for colorectal cancer. Additionally, a bibliometric investigation was performed on the public trends in the field of the magnetic nanoparticle to drug delivery and anticancer, which represented progressing applications of these carriers in the multidisciplinary zones with a general view on future research and identified potential opportunities and challenges. Furthermore, we outline the current challenges and forthcoming research perspective for high performance and fostering advanced MNPs in colorectal cancer treatment. Graphical Abstract

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