Multifunctional Magnetic Nanoparticles for Synergistic Enhancement of Cancer Treatment by Combinatorial Radio Frequency Thermolysis and Drug Delivery

2012 ◽  
Vol 1 (4) ◽  
pp. 493-501 ◽  
Author(s):  
Yang Xu ◽  
Alokita Karmakar ◽  
Wolf E. Heberlein ◽  
Thikra Mustafa ◽  
Alexandru R. Biris ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Radio Frequency ◽  
Cancer Treatment ◽  
Synergistic Enhancement

Localized cancer treatment by radio-frequency hyperthermia using magnetic nanoparticles immobilized on graphene oxide: from novel synthesis to in vitro studies

2018 ◽  
Vol 6 (33) ◽  
pp. 5385-5399 ◽  
Author(s):  
Ravi Kumar ◽  
Anjali Chauhan ◽  
Sushil K. Jha ◽  
Bijoy Kumar Kuanr
Keyword(s):  
Graphene Oxide ◽  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Radio Frequency ◽  
Cancer Treatment ◽  
In Vitro Studies ◽  
Hybrid Nanocomposite ◽  
Novel Synthesis ◽  
Hyperthermia Therapy

Innovative, theranostic hybrid nanocomposite of graphene oxide and iron oxide for radio-frequency hyperthermia therapy.

IRON OXIDE MAGNETIC NANOPARTICLES AS DRUG DELIVERY SYSTEMS FOR BRAIN CANCER TREATMENT

2021 ◽  
Vol 2 (1) ◽  
pp. 55-66
Author(s):  
Oana Stefana Purcaru ◽  
Alexandra Costachi ◽  
Catalina Elena Cioc ◽  
Alice Buteica ◽  
Anica Dricu
Keyword(s):  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Cancer Treatment ◽  
Targeted Delivery ◽  
Drug Delivery Systems ◽  
High Grade Glioma ◽  
Delivery Systems ◽  
Cancer Drug ◽  
Vitro Effect

Nanotechnology offers a new horizon for cancer drug administration and systemic safety of oncological treatments. Compared with conventional pharmaceutical forms, nanoparticles (NPs) have many advantages such as larger surface, ability to adsorb and targeted delivery of different types of drugs, providing decreased side effects and a patient customed approach in cancer treatment. Due to their diverse chemical composition, NPs offer the possibility of developing innovative therapies, which may be also applied in glioblastoma treatment. Fe3O4 magnetic nanoparticles (MNPs) have been previously used in cancer treatment, as targeted drug delivery systems. Helianthin is an azo dye compound that we found to induce cell death in high grade glioma (HGG) cells. In this study, we analyzed the in vitro effect of MNPs loaded with Helianthin (HeMNPs) on a glioblastoma cell line (GB2B).

scholarly journals An overview and bibliometric analysis on the colorectal cancer therapy by magnetic functionalized nanoparticles for the responsive and targeted drug delivery

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Mahdieh Darroudi ◽  
Mehrdad Gholami ◽  
Majid Rezayi ◽  
Majid Khazaei
Keyword(s):  
Magnetic Field ◽  
Colorectal Cancer ◽  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Cancer Therapy ◽  
Cancer Treatment ◽  
High Performance ◽  
Future Research ◽  
General View ◽  
Research Perspective

AbstractWith the growing demands for personalized medicine and medical devices, nanomedicine is a modern scientific field, and research continues to apply nanomaterials for therapeutic and damaged tissue diagnosis. In this regard, substantial progress has been made in synthesizing magnetic nanoparticles with desired sizes, chemical composition, morphologies, and surface chemistry. Among these materials, nanomagnetic iron oxides have demonstrated promise as unique drug delivery carriers due to cancer treatment. This carrier could lead to responsive properties to a specific trigger, including heat, pH, alternative magnetic field, or even enzymes, through functionalization and coating of magnetic nanoparticles, along with biocompatibility, good chemical stability, easy functionalization, simple processing, and ability to localize to the tumor site with the assistance of external magnetic field. Current studies have focused on magnetic nanoparticles’ utilities in cancer therapy, especially for colorectal cancer. Additionally, a bibliometric investigation was performed on the public trends in the field of the magnetic nanoparticle to drug delivery and anticancer, which represented progressing applications of these carriers in the multidisciplinary zones with a general view on future research and identified potential opportunities and challenges. Furthermore, we outline the current challenges and forthcoming research perspective for high performance and fostering advanced MNPs in colorectal cancer treatment. Graphical Abstract

scholarly journals Magnetic nanoparticle-based therapeutic agents for thermo-chemotherapy treatment of cancer

Nanoscale ◽  
2014 ◽  
Vol 6 (20) ◽  
pp. 11553-11573 ◽  
Author(s):  
Aziliz Hervault ◽  
Nguyễn Thị Kim Thanh
Keyword(s):  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Synergistic Effect ◽  
Cancer Treatment ◽  
Magnetic Nanoparticle ◽  
Therapeutic Agents ◽  
Chemotherapy Treatment

Magnetic nanoparticles have great potential as mediators of localised heat as well as vehicles for drug delivery to have synergistic effect of thermo-chemotherapy for cancer treatment.

Optical Properties of Photodynamic Therapy Drugs in Different Environments: The Paradigmatic Case of Temoporfin

2020 ◽  
Author(s):  
busenur Aslanoglu ◽  
Ilya Yakavets ◽  
Vladimir Zorin ◽  
Henri-Pierre Lassalle ◽  
Francesca Ingrosso ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Optical Properties ◽  
Photodynamic Therapy ◽  
Minimally Invasive ◽  
Visible Light ◽  
Cancer Treatment ◽  
Singlet Oxygen ◽  
Tumor Cells ◽  
Molecular Oxygen ◽  
Computational Tools

Computational tools have been used to study the photophysical and photochemical features of photosensitizers in photodynamic therapy (PDT) –a minimally invasive, less aggressive alternative for cancer treatment. PDT is mainly based by the activation of molecular oxygen through the action of a photoexcited sensitizer (photosensitizer). Temoporfin, widely known as mTHPC, is a second-generation photosensitizer, which produces the cytotoxic singlet oxygen when irradiated with visible light and hence destroys tumor cells. However, the bioavailability of the mostly hydrophobic photosensitizer, and hence its incorporation into the cells, is fundamental to achieve the desired effect on malignant tissues by PDT. In this study, we focus on the optical properties of the temoporfin chromophore in different environments –in <i>vacuo</i>, in solution, encapsulated in drug delivery agents, namely cyclodextrin, and interacting with a lipid bilayer.

Matrix Metalloproteinases (MMPs) in Targeted Drug Delivery: Synthesis of a Potent and Highly Selective Inhibitor against Matrix Metalloproteinase- 7

2020 ◽  
Vol 20 (27) ◽  
pp. 2459-2471
Author(s):  
Ling-Li Wang ◽  
Bing Zhang ◽  
Ming-Hua Zheng ◽  
Yu-Zhong Xie ◽  
Chang-Jiang Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tumor Microenvironment ◽  
Matrix Metalloproteinases ◽  
Cancer Treatment ◽  
Targeted Drug Delivery ◽  
Selective Inhibitor ◽  
Migration And Invasion ◽  
Side Chains ◽  
Mesenchymal Transition ◽  
Targeted Drug

Background: Matrix metalloproteinases (MMPs) are a family of zinc endopeptidases that play a key role in both physiological and pathological tissue degradation. MMPs have reportedly shown great potentials in the degradation of the Extracellular Matrix (ECM), have shown great potentials in targeting bioactive and imaging agents in cancer treatment. MMPs could provoke Epithelial to Mesenchymal Transition (EMT) of cancer cells and manipulate their signaling, adhesion, migration and invasion to promote cancer cell aggressiveness. Therefore, targeting and particularly inhibiting MMPs within the tumor microenvironment is an effective strategy for cancer treatment. Based on this idea, different MMP inhibitors (MMPIs) have been developed to manipulate the tumor microenvironment towards conditions appropriate for the actions of antitumor agents. Studies are ongoing to improve the selectivity and specificity of MMPIs. Structural optimization has facilitated the discovery of selective inhibitors of the MMPs. However, so far no selective inhibitor for MMP-7 has been proposed. Aims: This study aims to comprehensively review the potentials and advances in applications of MMPs particularly MMP-7 in targeted cancer treatment approaches with the main focus on targeted drug delivery. Different targeting strategies for manipulating and inhibiting MMPs for the treatment of cancer are discussed. MMPs are upregulated at all stages of expression in cancers. Different MMP subtypes have shown significant targeting applicability at the genetic, protein, and activity levels in both physiological and pathophysiological conditions in a variety of cancers. The expression of MMPs significantly increases at advanced cancer stages, which can be used for controlled release in cancers in advance stages. Methods: Moreover, this study presents the synthesis and characteristics of a new and highly selective inhibitor against MMP-7 and discusses its applications in targeted drug delivery systems for therapeutics and diagnostics modalities. Results: Our findings showed that the structure of the inhibitor P3’ side chains play the crucial role in developing an optimized MMP-7 inhibitor with high selectivity and significant degradation activities against ECM. Conclusion: Optimized NDC can serve as a highly potent and selective inhibitor against MMP-7 following screening and optimization of the P3’ side chains, with a Ki of 38.6 nM and an inhibitory selectivity of 575 of MMP-7 over MMP-1.

Co-delivery of Doxorubicin and D-α-Tocopherol Polyethylene Glycol 1000 Succinate by Magnetic Nanoparticles

2018 ◽  
Vol 18 (8) ◽  
pp. 1138-1147 ◽  
Author(s):  
Esra Metin ◽  
Pelin Mutlu ◽  
Ufuk Gündüz
Keyword(s):  
Breast Cancer ◽  
Polyethylene Glycol ◽  
Magnetic Nanoparticles ◽  
Cancer Treatment ◽  
Cancer Cells ◽  
Drug Loading ◽  
Gravimetric Analysis ◽  
Polyethylene Glycol 1000 ◽  
Mcf 7

Background: Although conventional chemotherapy is the most common method for cancer treatment, it has several side effects such as neuropathy, alopecia and cardiotoxicity. Since the drugs are given to body systemically, normal cells are also affected, just like cancer cells. However, in recent years, targeted drug delivery has been developed to overcome these drawbacks. Objective: The aim of this study was targeted co-delivery of doxorubicin (Dox) which is an anticancer agent and D-α-Tocopherol polyethylene glycol 1000 succinate (vitamin E TPGS or simply TPGS) to breast cancer cells. For this purpose, Magnetic Nanoparticles (MNPs) were synthesized and coated with Oleic Acid (OA). Coated nanoparticles were encapsulated in Poly Lactic-co-Glycolic Acid (PLGA) and TPGS polymers and loaded with Dox. The Nanoparticles (NPs) were characterized by Fourier Transform Infrared (FTIR) spectroscopy, zetapotential analysis, Dynamic Light Scattering (DLS) analysis, Thermal Gravimetric Analysis (TGA) and Scanning Electron Microscope (SEM) analysis. Results: The results showed that NPs were spherical, superparamagnetic and in the desired range for use in drug targeting. The targetability of NPs was confirmed. Moreover, TPGS and Dox loading was shown by TGA and FTIR analyses. NPs were internalized by cells and the cytotoxic effect of drug loaded NPs on sensitive (MCF-7) and drug-resistant (MCF-7/Dox) cells were examined. It was seen that the presence of TPGS increased cytotoxicity significantly. TPGS also enhanced drug loading efficiency, release rate, cellular internalization. In MCF- 7/Dox cells, the drug resistance seems to be decreased when Dox is loaded onto TPGS containing NPs. Conclusion: This magnetic PLGA nanoparticle system is important for new generation targeted chemotherapy and could be used for breast cancer treatment after in vivo tests.

Bioevaluation of glucose-modified liposomes as a potential drug delivery system for cancer treatment using 177-Lu radiotracking

2021 ◽  
Vol 332 ◽  
pp. 301-311
Author(s):  
Đorđe Cvjetinović ◽  
Željko Prijović ◽  
Drina Janković ◽  
Magdalena Radović ◽  
Marija Mirković ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Treatment ◽  
Drug Delivery System ◽  
Delivery System ◽  
Potential Drug
Sign in / Sign up

Export Citation Format

Share Document