MRI nanoprobes based on chemical exchange saturation transfer: LnIII chelates anchored on the surface of mesoporous silica nanoparticles

Nanoscale ◽  
2014 ◽  
Vol 6 (16) ◽  
pp. 9604-9607 ◽  
Author(s):  
Giuseppe Ferrauto ◽  
Fabio Carniato ◽  
Lorenzo Tei ◽  
He Hu ◽  
Silvio Aime ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Chemical Exchange ◽  
Mesoporous Silica Nanoparticles ◽  
Paramagnetic Shift ◽  
Chemical Exchange Saturation Transfer ◽  
Saturation Transfer ◽  
Highly Sensitive ◽  
Cest Mri ◽  
Mcm 41

LnIII–DO3A complexes anchored to MCM-41 mesoporous silica nanoparticles induce a strong paramagnetic shift of proximate silanol protons behaving as highly sensitive chemical exchange saturation transfer (CEST) MRI nanoprobes.

scholarly journals Water Diffusion Modulates the CEST Effect on Tb(III)-Mesoporous Silica Probes

2020 ◽  
Vol 6 (3) ◽  
pp. 38
Author(s):  
Fabio Carniato ◽  
Giuseppe Ferrauto ◽  
Mónica Muñoz-Úbeda ◽  
Lorenzo Tei
Keyword(s):  
Mesoporous Silica ◽  
Chemical Exchange ◽  
Mesoporous Silica Nanoparticles ◽  
Bulk Water ◽  
Water Diffusion ◽  
Chemical Exchange Saturation Transfer ◽  
Order Of Magnitude ◽  
Tem Microscopy ◽  
Magnetic Resonance Imaging Mri ◽  
Mcm 41

The anchoring of lanthanide(III) chelates on the surface of mesoporous silica nanoparticles (MSNs) allowed their investigation as magnetic resonance imaging (MRI) and chemical exchange saturation transfer (CEST) contrast agents. Since their efficiency is strongly related to the interaction occurring between Ln-chelates and “bulk” water, an estimation of the water diffusion inside MSNs channels is very relevant. Herein, a method based on the exploitation of the CEST properties of TbDO3A-MSNs was applied to evaluate the effect of water diffusion inside MSN channels. Two MSNs, namely MCM-41 and SBA-15, with different pores size distributions were functionalized with TbDO3A-like chelates and polyethylene glycol (PEG) molecules and characterized by HR-TEM microscopy, IR spectroscopy, N2 physisorption, and thermogravimetric analysis (TGA). The different distribution of Tb-complexes in the two systems, mainly on the external surface in case of MCM-41 or inside the internal pores for SBA-15, resulted in variable CEST efficiency. Since water molecules diffuse slowly inside silica channels, the CEST effect of the LnDO3A-SBA-15 system was found to be one order of magnitude lower than in the case of TbDO3A-MCM-41. The latter system reaches an excellent sensitivity of ca. 55 ± 5 μM, which is useful for future theranostic or imaging applications.

scholarly journals A generalized ratiometric chemical exchange saturation transfer (CEST) MRI approach for mapping renal pH using iopamidol

2017 ◽  
Vol 79 (3) ◽  
pp. 1553-1558 ◽  
Author(s):  
Yin Wu ◽  
Iris Y. Zhou ◽  
Takahiro Igarashi ◽  
Dario L. Longo ◽  
Silvio Aime ◽  
...  
Keyword(s):  
Chemical Exchange ◽  
Chemical Exchange Saturation Transfer ◽  
Saturation Transfer ◽  
Cest Mri

Lanthanide-Loaded Erythrocytes As Highly Sensitive Chemical Exchange Saturation Transfer MRI Contrast Agents

2013 ◽  
Vol 136 (2) ◽  
pp. 638-641 ◽  
Author(s):  
Giuseppe Ferrauto ◽  
Daniela Delli Castelli ◽  
Enza Di Gregorio ◽  
Sander Langereis ◽  
Dirk Burdinski ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Chemical Exchange ◽  
Mri Contrast Agents ◽  
Chemical Exchange Saturation Transfer ◽  
Saturation Transfer ◽  
Mri Contrast ◽  
Highly Sensitive

Fluoride ion sensing in aqueous medium by employing nitrobenzoxadiazole-postgrafted mesoporous silica nanoparticles (MCM-41)

2015 ◽  
Vol 17 (5) ◽  
pp. 3525-3533 ◽  
Author(s):  
Gaurav Jha ◽  
Anoop N. ◽  
Abdur Rahaman ◽  
Moloy Sarkar
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Aqueous Medium ◽  
Mesoporous Silica Nanoparticles ◽  
Fluoride Ion ◽  
Selective Detection ◽  
Ion Sensing ◽  
Mcm 41

A nitrobenzoxadiazole (NBD) anchored mesoporous silica-based system has been designed and developed for the selective detection of fluoride in aqueous medium.

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