A novel calibration strategy for the quantitative imaging of iron in biological tissues by LA-ICP-MS using matrix-matched standards and internal standardisation

2014 ◽  
Vol 29 (8) ◽  
pp. 1378-1384 ◽  
Author(s):  
Jennifer O'Reilly ◽  
David Douglas ◽  
Julian Braybrook ◽  
P.-W. So ◽  
Eva Vergucht ◽  
...  
Keyword(s):  
Quantitative Imaging ◽  
Biological Tissues ◽  
Tissue Imaging ◽  
Calibration Standards ◽  
Icp Ms ◽  
Straightforward Approach

This paper describes the development of a simple and straightforward approach for preparation of matrix-matched calibration standards for Fe quantitative tissue imaging by LA-ICP-MS.

Quantitative imaging of translocated silver following nanoparticle exposure by laser ablation-inductively coupled plasma-mass spectrometry

2018 ◽  
Vol 10 (8) ◽  
pp. 836-840 ◽  
Author(s):  
David P. Bishop ◽  
Mandy Grossgarten ◽  
Dörthe Dietrich ◽  
Antje Vennemann ◽  
Nerida Cole ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Laser Ablation ◽  
Inductively Coupled Plasma ◽  
Quantitative Imaging ◽  
Nanoparticle Exposure ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry

We demonstrate the use of LA-ICP-MS for determining the location and quantification of silver in a rat spleen following nanoparticle exposure.

scholarly journals A Review of Endogenous and Exogenous Contrast Agents Used in Photoacoustic Tomography with Different Sensing Configurations

Sensors ◽  
2020 ◽  
Vol 20 (19) ◽  
pp. 5595 ◽  
Author(s):  
Victor T.C. Tsang ◽  
Xiufeng Li ◽  
Terence T.W. Wong
Keyword(s):  
Contrast Agents ◽  
Biomedical Imaging ◽  
Imaging Modality ◽  
Biological Tissues ◽  
Tissue Imaging ◽  
Imaging Tool ◽  
Endogenous Contrast ◽  
Deep Tissue Imaging ◽  
Molecular Specificity ◽  
System Configurations

Optical-based sensing approaches have long been an indispensable way to detect molecules in biological tissues for various biomedical research and applications. The advancement in optical microscopy is one of the main drivers for discoveries and innovations in both life science and biomedical imaging. However, the shallow imaging depth due to the use of ballistic photons fundamentally limits optical imaging approaches’ translational potential to a clinical setting. Photoacoustic (PA) tomography (PAT) is a rapidly growing hybrid imaging modality that is capable of acoustically detecting optical contrast. PAT uniquely enjoys high-resolution deep-tissue imaging owing to the utilization of diffused photons. The exploration of endogenous contrast agents and the development of exogenous contrast agents further improve the molecular specificity for PAT. PAT’s versatile design and non-invasive nature have proven its great potential as a biomedical imaging tool for a multitude of biomedical applications. In this review, representative endogenous and exogenous PA contrast agents will be introduced alongside common PAT system configurations, including the latest advances of all-optical acoustic sensing techniques.

Development of matrix-matching hydroxyapatite calibration standards for quantitative multi-element LA-ICP-MS analysis: application to the dorsal spine of fish

2011 ◽  
Vol 26 (7) ◽  
pp. 1421 ◽  
Author(s):  
Ana Ugarte ◽  
Nora Unceta ◽  
Christophe Pécheyran ◽  
M. Aránzazu Goicolea ◽  
Ramón J. Barrio
Keyword(s):  
Dorsal Spine ◽  
Calibration Standards ◽  
Ms Analysis ◽  
Icp Ms ◽  
Analysis Application

scholarly journals Cerebral Ultrasound Time-Harmonic Elastography Reveals Softening of the Human Brain Due to Dehydration

2021 ◽  
Vol 11 ◽  
Author(s):  
Bernhard Kreft ◽  
Judith Bergs ◽  
Mehrgan Shahryari ◽  
Leon Alexander Danyel ◽  
Stefan Hetzer ◽  
...  
Keyword(s):  
Soft Tissues ◽  
Quantitative Imaging ◽  
Urine Osmolality ◽  
Biological Tissues ◽  
Shear Wave Speed ◽  
Water Drinking ◽  
Time Harmonic ◽  
Cerebral Ultrasound ◽  
Overnight Fasting ◽  
Volume Blood

Hydration influences blood volume, blood viscosity, and water content in soft tissues – variables that determine the biophysical properties of biological tissues including their stiffness. In the brain, the relationship between hydration and stiffness is largely unknown despite the increasing importance of stiffness as a quantitative imaging marker. In this study, we investigated cerebral stiffness (CS) in 12 healthy volunteers using ultrasound time-harmonic elastography (THE) in different hydration states: (i) during normal hydration, (ii) after overnight fasting, and (iii) within 1 h of drinking 12 ml of water per kg body weight. In addition, we correlated shear wave speed (SWS) with urine osmolality and hematocrit. SWS at normal hydration was 1.64 ± 0.02 m/s and decreased to 1.57 ± 0.04 m/s (p < 0.001) after overnight fasting. SWS increased again to 1.63 ± 0.01 m/s within 30 min of water drinking, returning to values measured during normal hydration (p = 0.85). Urine osmolality at normal hydration (324 ± 148 mOsm/kg) increased to 784 ± 107 mOsm/kg (p < 0.001) after fasting and returned to normal (288 ± 128 mOsm/kg, p = 0.83) after water drinking. SWS and urine osmolality correlated linearly (r = −0.68, p < 0.001), while SWS and hematocrit did not correlate (p = 0.31). Our results suggest that mild dehydration in the range of diurnal fluctuations is associated with significant softening of brain tissue, possibly due to reduced cerebral perfusion. To ensure consistency of results, it is important that cerebral elastography with a standardized protocol is performed during normal hydration.

scholarly journals Recent Advances in Metal-Based Magnetic Composites as High-Efficiency Candidates for Ultrasound-Assisted Effects in Cancer Therapy

2021 ◽  
Vol 22 (19) ◽  
pp. 10461
Author(s):  
Zhenyu Wang ◽  
Xiaoxiao He ◽  
Shiyue Chen ◽  
Chengdian He ◽  
Teng Wang ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Cancer Cells ◽  
Magnetic Materials ◽  
High Efficiency ◽  
Structural Information ◽  
Drug Loading ◽  
Biological Tissues ◽  
Tissue Imaging ◽  
Mechanical Stimuli ◽  
Magnetic Composites

Metal-based magnetic materials have been used in different fields due to their particular physical or chemical properties. The original magnetic properties can be influenced by the composition of constituent metals. As utilized in different application fields, such as imaging monitoring, thermal treatment, and combined integration in cancer therapies, fabricated metal-based magnetic materials can be doped with target metal elements in research. Furthermore, there is one possible new trend in human activities and basic cancer treatment. As has appeared in characterizations such as magnetic resonance, catalytic performance, thermal efficiency, etc., structural information about the real morphology, size distribution, and composition play important roles in its further applications. In cancer studies, metal-based magnetic materials are considered one appropriate material because of their ability to penetrate biological tissues, interact with cellular components, and induce noxious effects. The disruptions of cytoskeletons, membranes, and the generation of reactive oxygen species (ROS) further influence the efficiency of metal-based magnetic materials in related applications. While combining with cancer cells, these magnetic materials are not only applied in imaging monitoring focus areas but also could give the exact area information in the cure process while integrating ultrasound treatment. Here, we provide an overview of metal-based magnetic materials of various types and then their real applications in the magnetic resonance imaging (MRI) field and cancer cell treatments. We will demonstrate advancements in using ultrasound fields co-worked with MRI or ROS approaches. Besides iron oxides, there is a super-family of heterogeneous magnetic materials used as magnetic agents, imaging materials, catalytic candidates in cell signaling and tissue imaging, and the expression of cancer cells and their high sensitivity to chemical, thermal, and mechanical stimuli. On the other hand, the interactions between magnetic candidates and cancer tissues may be used in drug delivery systems. The materials’ surface structure characteristics are introduced as drug loading substrates as much as possible. We emphasize that further research is required to fully characterize the mechanisms of underlying ultrasounds induced together, and their appropriate relevance for materials toxicology and biomedical applications.

scholarly journals Quantitative mapping of specific proteins in biological tissues by laser ablation–ICP-MS using exogenous labels: aspects to be considered

2018 ◽  
Vol 411 (3) ◽  
pp. 549-558 ◽  
Author(s):  
María Cruz-Alonso ◽  
Ana Lores-Padín ◽  
Eva Valencia ◽  
Héctor González-Iglesias ◽  
Beatriz Fernández ◽  
...  
Keyword(s):  
Laser Ablation ◽  
Biological Tissues ◽  
Quantitative Mapping ◽  
Icp Ms ◽  
Specific Proteins

Quantification of local zinc and tungsten deposits in bone with LA-ICP-MS using novel hydroxyapatite-collagen calibration standards”

2021 ◽  
Author(s):  
Cassidy R VanderSchee ◽  
David Frier ◽  
David Kuter ◽  
Koren Mann ◽  
Brian P Jackson ◽  
...  
Keyword(s):  
Bone Remodeling ◽  
Calibration Standards ◽  
Icp Ms ◽  
Tungsten Deposits ◽  
And Tungsten

Tungsten has recently emerged as a potential toxicant and is known to heterogeneously deposit in bone as reactive polytungstates. Zinc, which accumulates in regions of bone remodeling, also has a...

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