Terbium-doped gadolinium oxide nanoparticles prepared by laser ablation in liquid for use as a fluorescence and magnetic resonance imaging dual-modal contrast agent

2015 ◽  
Vol 17 (2) ◽  
pp. 1189-1196 ◽  
Author(s):  
Fei Chen ◽  
Min Chen ◽  
Chuan Yang ◽  
Jun Liu ◽  
Ningqi Luo ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Laser Ablation ◽  
Magnetic Resonance ◽  
Mr Imaging ◽  
Contrast Agent ◽  
Fluorescence Imaging ◽  
Oxide Nanoparticles ◽  
Resonance Imaging ◽  
Laser Ablation In Liquid ◽  
Promising Candidate

Gd2O3:Tb is a promising candidate for use as a dual-modal contrast agent combining fluorescence imaging with MR imaging.

EDTA capped iron oxide nanoparticles magnetic micelles: drug delivery vehicle for treatment of chronic myeloid leukemia and T1–T2 dual contrast agent for magnetic resonance imaging

2016 ◽  
Vol 40 (11) ◽  
pp. 9507-9519 ◽  
Author(s):  
Ekta Shah ◽  
Pratik Upadhyay ◽  
Mala Singh ◽  
Mohmmad Shoab Mansuri ◽  
Rasheedunnisa Begum ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Drug Delivery ◽  
Iron Oxide ◽  
Magnetic Resonance ◽  
Chronic Myeloid Leukemia ◽  
Contrast Agent ◽  
Myeloid Leukemia ◽  
Oxide Nanoparticles ◽  
Resonance Imaging ◽  
Delivery Vehicle

This study shows that multiple functionalities like drug delivery and T1–T2 dual modalities can be achieved by a proper surface architecture.

Quantitative renal cortical perfusion in human subjects with magnetic resonance imaging using iron-oxide nanoparticles: influence of t1 shortening

2008 ◽  
Vol 49 (8) ◽  
pp. 955-962 ◽  
Author(s):  
A. Morell ◽  
H. Ahlstrom ◽  
S. O. Schoenberg ◽  
A. Abildgaard ◽  
M. Bock ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Resonance Imaging ◽  
Quantitative Perfusion ◽  
Intravascular Contrast Agent ◽  
Cortical Perfusion

Background: Using conventional contrast agents, the technique of quantitative perfusion by observing the transport of a bolus with magnetic resonance imaging (MRI) is limited to the brain due to extravascular leakage. Purpose: To perform quantitative perfusion measurements in humans with an intravascular contrast agent, and to estimate the influence of the T1 relaxivity of the contrast agent on the first-pass response. Material and Methods: Renal cortical perfusion was measured quantitatively in six patients with unilateral renal artery stenosis using a rapid gradient double-echo sequence in combination with an intravenous bolus injection of NC100150 Injection, an intravascular contrast agent based on iron-oxide nanoparticles. The influence of T1 relaxivity was measured by comparing perfusion results based on single- and double-echo data. Results: The mean values of cortical blood flow, cortical blood volume, and mean transit time in the normal kidneys were measured to 339±60 ml/min/100 g, 41±8 ml/100 g, and 7.3±1.0 s, respectively, based on double-echo data. The corresponding results based on single-echo data, which are not compensated for the T1 relaxivity, were 254±47 ml/min/100 g, 27±3 ml/100 g, and 6±1.2 s, respectively. Conclusion: The use of a double-echo sequence enabled elimination of confounding T1 effects and consequent systematic underestimation of the perfusion.

scholarly journals SPIO-Loaded Nanostructured Lipid Carriers for T2-weighted Magnetic Resonance Imaging of Hepatocarcinoma

2020 ◽  
Author(s):  
Chen-ying Lu ◽  
Nan-Nan Zhang ◽  
Gao-feng Shu ◽  
Xiu-liang Zhu ◽  
Min-jiang Chen ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Hepatocellular Carcinoma ◽  
Magnetic Resonance ◽  
Mr Imaging ◽  
Contrast Agent ◽  
Diffusion Method ◽  
Nanostructured Lipid Carrier ◽  
Resonance Imaging ◽  
Mri Contrast

Abstract Background The development of sensitive and specific MRI contrast agents for early diagnosis of hepatocellular carcinoma is highly demanded. Here, a peptide A54 (sequence: AGKGTPSLETTP) functionalized superparamagnetic iron oxide nanoparticles (SPIONs)-based magnetic nanostructured lipid carrier(A54-MNLC)as a hepatoma targeting negative magnetic resonance imaging (MRI) contrast agent was developed. Results Firstly, the A54 peptide functionalized PEGylated SA (A54-PEG-SA) was synthesized by the coupling reaction between A54 and NH2-PEG-SA. Then SPIONs-loaded MNLC(MNLC and A54-MNLC)were prepared by the solvent diffusion method. The A54-MNLC with a diameter of about 50 nm, and in vitro cell viability study revealed that the prepared A54-MNLC was cytocompatible in the given particles’ concentration ranges. The cellular uptake results indicated that A54-MNLC was able to be uptaken specifically by human hepatoma cell line (Bel-7402 cells) and also can be used as efficient probe for targeted MR imaging of cancer cells in vitro. The in vivo MR imaging experiments using an orthotopic implantation model further validated the hepatoma-targeting ability of A54-MNLC with a more remarkable MR imaging contrast effect compared to MNLC. Conclusions These results demonstrate that the A54-MNLC is a promising nanoplatform as a targeted MR imaging contrast agent for the diagnosis of hepatocellular carcinoma.

scholarly journals The influence of Gd-DOTA ratios conjugating PLGA-PEG micelles encapsulated IR-1061 in bimodal over–1000 nm near–infrared fluorescence and magnetic resonance imaging

2022 ◽  
Author(s):  
Doan Thi Kim Dung ◽  
Masakazu Umezawa ◽  
Kazunobu Ohnuki ◽  
Karina Nigoghossian ◽  
Kyohei Okubo ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Mr Imaging ◽  
Fluorescence Imaging ◽  
Multimodal Imaging ◽  
Near Infrared ◽  
Resonance Imaging ◽  
Biological Objects ◽  
Nir Fluorescence ◽  
Multidimensional Information

Multimodal imaging can provide multidimensional information for understanding concealed microstructures or bioprocesses in biological objects. The combination of over–1000 nm near–infrared (OTN–NIR) fluorescence imaging and magnetic resonance (MR) imaging is...

Gold-Coated Iron Oxide Nanoparticles as a T2 Contrast Agent in Magnetic Resonance Imaging

2012 ◽  
Vol 12 (7) ◽  
pp. 5132-5137 ◽  
Author(s):  
Tanveer Ahmad ◽  
Hongsub Bae ◽  
Ilsu Rhee ◽  
Yongmin Chang ◽  
Seong-Uk Jin ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Resonance Imaging
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