EDTA capped iron oxide nanoparticles magnetic micelles: drug delivery vehicle for treatment of chronic myeloid leukemia and T1–T2 dual contrast agent for magnetic resonance imaging

2016 ◽  
Vol 40 (11) ◽  
pp. 9507-9519 ◽  
Author(s):  
Ekta Shah ◽  
Pratik Upadhyay ◽  
Mala Singh ◽  
Mohmmad Shoab Mansuri ◽  
Rasheedunnisa Begum ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Drug Delivery ◽  
Iron Oxide ◽  
Magnetic Resonance ◽  
Chronic Myeloid Leukemia ◽  
Contrast Agent ◽  
Myeloid Leukemia ◽  
Oxide Nanoparticles ◽  
Resonance Imaging ◽  
Delivery Vehicle

This study shows that multiple functionalities like drug delivery and T1–T2 dual modalities can be achieved by a proper surface architecture.

Quantitative renal cortical perfusion in human subjects with magnetic resonance imaging using iron-oxide nanoparticles: influence of t1 shortening

2008 ◽  
Vol 49 (8) ◽  
pp. 955-962 ◽  
Author(s):  
A. Morell ◽  
H. Ahlstrom ◽  
S. O. Schoenberg ◽  
A. Abildgaard ◽  
M. Bock ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Resonance Imaging ◽  
Quantitative Perfusion ◽  
Intravascular Contrast Agent ◽  
Cortical Perfusion

Background: Using conventional contrast agents, the technique of quantitative perfusion by observing the transport of a bolus with magnetic resonance imaging (MRI) is limited to the brain due to extravascular leakage. Purpose: To perform quantitative perfusion measurements in humans with an intravascular contrast agent, and to estimate the influence of the T1 relaxivity of the contrast agent on the first-pass response. Material and Methods: Renal cortical perfusion was measured quantitatively in six patients with unilateral renal artery stenosis using a rapid gradient double-echo sequence in combination with an intravenous bolus injection of NC100150 Injection, an intravascular contrast agent based on iron-oxide nanoparticles. The influence of T1 relaxivity was measured by comparing perfusion results based on single- and double-echo data. Results: The mean values of cortical blood flow, cortical blood volume, and mean transit time in the normal kidneys were measured to 339±60 ml/min/100 g, 41±8 ml/100 g, and 7.3±1.0 s, respectively, based on double-echo data. The corresponding results based on single-echo data, which are not compensated for the T1 relaxivity, were 254±47 ml/min/100 g, 27±3 ml/100 g, and 6±1.2 s, respectively. Conclusion: The use of a double-echo sequence enabled elimination of confounding T1 effects and consequent systematic underestimation of the perfusion.

Gold-Coated Iron Oxide Nanoparticles as a T2 Contrast Agent in Magnetic Resonance Imaging

2012 ◽  
Vol 12 (7) ◽  
pp. 5132-5137 ◽  
Author(s):  
Tanveer Ahmad ◽  
Hongsub Bae ◽  
Ilsu Rhee ◽  
Yongmin Chang ◽  
Seong-Uk Jin ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Resonance Imaging
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