Gold-Coated Iron Oxide Nanoparticles as a T2 Contrast Agent in Magnetic Resonance Imaging

2012 ◽  
Vol 12 (7) ◽  
pp. 5132-5137 ◽  
Author(s):  
Tanveer Ahmad ◽  
Hongsub Bae ◽  
Ilsu Rhee ◽  
Yongmin Chang ◽  
Seong-Uk Jin ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Resonance Imaging

Quantitative renal cortical perfusion in human subjects with magnetic resonance imaging using iron-oxide nanoparticles: influence of t1 shortening

2008 ◽  
Vol 49 (8) ◽  
pp. 955-962 ◽  
Author(s):  
A. Morell ◽  
H. Ahlstrom ◽  
S. O. Schoenberg ◽  
A. Abildgaard ◽  
M. Bock ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Resonance Imaging ◽  
Quantitative Perfusion ◽  
Intravascular Contrast Agent ◽  
Cortical Perfusion

Background: Using conventional contrast agents, the technique of quantitative perfusion by observing the transport of a bolus with magnetic resonance imaging (MRI) is limited to the brain due to extravascular leakage. Purpose: To perform quantitative perfusion measurements in humans with an intravascular contrast agent, and to estimate the influence of the T1 relaxivity of the contrast agent on the first-pass response. Material and Methods: Renal cortical perfusion was measured quantitatively in six patients with unilateral renal artery stenosis using a rapid gradient double-echo sequence in combination with an intravenous bolus injection of NC100150 Injection, an intravascular contrast agent based on iron-oxide nanoparticles. The influence of T1 relaxivity was measured by comparing perfusion results based on single- and double-echo data. Results: The mean values of cortical blood flow, cortical blood volume, and mean transit time in the normal kidneys were measured to 339±60 ml/min/100 g, 41±8 ml/100 g, and 7.3±1.0 s, respectively, based on double-echo data. The corresponding results based on single-echo data, which are not compensated for the T1 relaxivity, were 254±47 ml/min/100 g, 27±3 ml/100 g, and 6±1.2 s, respectively. Conclusion: The use of a double-echo sequence enabled elimination of confounding T1 effects and consequent systematic underestimation of the perfusion.

scholarly journals Pluronic F127-Folate Coated Super Paramagenic Iron Oxide Nanoparticles as Contrast Agent for Cancer Diagnosis in Magnetic Resonance Imaging

Polymers ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 743 ◽  
Author(s):  
Hieu Vu-Quang ◽  
Mads Sloth Vinding ◽  
Thomas Nielsen ◽  
Marcus Görge Ullisch ◽  
Niels Chr. Nielsen ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Iron Oxide Nanoparticles ◽  
Folate Receptor ◽  
Pluronic F127 ◽  
Confocal Laser ◽  
Oxide Nanoparticles ◽  
Resonance Imaging

Contrast agents have been widely used in medicine to enhance contrast in magnetic resonance imaging (MRI). Among them, super paramagnetic iron oxide nanoparticles (SPION) have been reported to have low risk in clinical use. In our study, F127-Folate coated SPION was fabricated in order to efficiently target tumors and provide imaging contrast in MRI. SPION alone have an average core size of 15 nm. After stabilizing with Pluronic F127, the nanoparticles reached a hydrodynamic size of 180 nm and dispersed well in various kinds of media. The F127-Folate coated SPION were shown to specifically target folate receptor expressing cancer cells by flow cytometry analysis, confocal laser scanning microscope, as well as in vitro MRI. Furthermore, in vivo MRI images have shown the enhanced negative contrast from the F127-Folate coated SPION in tumor-bearing mice. In conclusion, our F127-Folate coated SPION have shown great potential as a contrast agent in MRI, as well as in the combination with drug delivery for cancer therapy.

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