A new turn on Pd2+-specific fluorescence probe and its use as an imaging reagent for cellular uptake in Hct116 cells

2015 ◽  
Vol 51 (17) ◽  
pp. 3649-3652 ◽  
Author(s):  
Upendar Reddy G. ◽  
Firoj Ali ◽  
Nandaraj Taye ◽  
Samit Chattopadhyay ◽  
Amitava Das
Keyword(s):  
Cellular Uptake ◽  
Fluorescence Probe ◽  
Quantitative Estimation ◽  
Biological Fluids ◽  
Molecular Probe ◽  
Specific Fluorescence ◽  
Turn On ◽  
Hct116 Cells

A new molecular probe that is used as an imaging reagent for detection of cellular uptake of Pd(ii) in Hct116 cells and for quantitative estimation of Pd(ii) in biological fluids.

A metal-free fluorescence turn-on molecular probe for detection of nucleoside triphosphates

2017 ◽  
Vol 53 (1) ◽  
pp. 208-211 ◽  
Author(s):  
Debabrata Maity ◽  
Mao Li ◽  
Martin Ehlers ◽  
Carsten Schmuck
Keyword(s):  
Fluorescence Probe ◽  
Anion Binding ◽  
Molecular Probe ◽  
Binding Motif ◽  
Metal Free ◽  
Turn On ◽  
Nucleoside Triphosphates ◽  
Fluorescence Turn On

We report a fluorescence probe 1, which contains a naphthalimide fluorophore with two symmetric peptidic arms equipped with a tailor-made anion-binding motif, the guanidiniocarbonyl pyrrole moiety, for the detection of nucleoside triphosphates.

A novel fluorescence probe for estimation of cysteine/histidine in human blood plasma and recognition of endogenous cysteine in live Hct116 cells

2014 ◽  
Vol 50 (69) ◽  
pp. 9899-9902 ◽  
Author(s):  
Upendar Reddy G. ◽  
Hridesh Agarwalla ◽  
Nandaraj Taye ◽  
Suvankar Ghorai ◽  
Samit Chattopadhyay ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Blood Plasma ◽  
Human Blood ◽  
Plasma Sample ◽  
Fluorescence Probe ◽  
Quantitative Estimation ◽  
Human Blood Plasma ◽  
Blood Plasma Sample ◽  
Hct116 Cells

A new cell membrane permeable reagent for detection of endogenous Cys as well as quantitative estimation of Cys and His in a human blood plasma sample.

High-Specific Fluorescence Probe for SO32− Detection and Bioimaging

2021 ◽  
Author(s):  
Jianbin Chao ◽  
Jiamin Zhao ◽  
Yongbin Zhang ◽  
Fangjun Huo ◽  
Caixia Yin ◽  
...  
Keyword(s):  
Fluorescence Probe ◽  
Specific Fluorescence

scholarly journals Quantum Dots as a Good Carriers of Unsymmetrical Bisacridines for Modulating Cellular Uptake and the Biological Response in Lung and Colon Cancer Cells

Nanomaterials ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 462 ◽  
Author(s):  
Joanna Pilch ◽  
Patrycja Kowalik ◽  
Piotr Bujak ◽  
Anna M. Nowicka ◽  
Ewa Augustin
Keyword(s):  
Quantum Dots ◽  
Cancer Cells ◽  
Cellular Uptake ◽  
Laser Scanning ◽  
Biological Response ◽  
Drug Carriers ◽  
Confocal Laser ◽  
Normal Cells ◽  
H460 Cells ◽  
Hct116 Cells

Nanotechnology-based drug delivery provides a promising area for improving the efficacy of cancer treatments. Therefore, we investigate the potential of using quantum dots (QDs) as drug carriers for antitumor unsymmetrical bisacridine derivatives (UAs) to cancer cells. We examine the influence of QD–UA hybrids on the cellular uptake, internalization (Confocal Laser Scanning Microscope), and the biological response (flow cytometry and light microscopy) in lung H460 and colon HCT116 cancer cells. We show the time-dependent cellular uptake of QD–UA hybrids, which were more efficiently retained inside the cells compared to UAs alone, especially in H460 cells, which could be due to multiple endocytosis pathways. In contrast, in HCT116 cells, the hybrids were taken up only by one endocytosis mechanism. Both UAs and their hybrids induced apoptosis in H460 and HCT116 cells (to a greater extent in H460). Cells which did not die underwent senescence more efficiently following QDs–UAs treatment, compared to UAs alone. Cellular senescence was not observed in HCT116 cells following treatment with both UAs and their hybrids. Importantly, QDgreen/red themselves did not provoke toxic responses in cancer or normal cells. In conclusion, QDs are good candidates for targeted UA delivery carriers to cancer cells while protecting normal cells from toxic drug activities.

scholarly journals A Highly Selective Turn-On Fluorescent Probe for the Detection of Zinc

Molecules ◽  
2021 ◽  
Vol 26 (13) ◽  
pp. 3825
Author(s):  
Ling-Yi Shen ◽  
Xiao-Li Chen ◽  
Xian-Jiong Yang ◽  
Hong Xu ◽  
Ya-Li Huang ◽  
...  
Keyword(s):  
High Selectivity ◽  
Fluorescence Probe ◽  
Stoichiometric Ratio ◽  
X Ray Diffraction ◽  
X Ray ◽  
Turn On ◽  
Imine Nitrogen ◽  
System A ◽  
Plot Analysis ◽  
L System

A novel turn-on fluorescence probe L has been designed that exhibits high selectivity and sensitivity with a detection limit of 9.53 × 10−8 mol/L for the quantification of Zn2+. 1H-NMR spectroscopy and single crystal X-ray diffraction analysis revealed the unsymmetrical nature of the structure of the Schiff base probe L. An emission titration experiment in the presence of different molar fractions of Zn2+ was used to perform a Job’s plot analysis. The results showed that the stoichiometric ratio of the complex formed by L and Zn2+ was 1:1. Moreover, the molecular structure of the mononuclear Cu complex reveals one ligand L coordinates with one Cu atom in the asymmetric unit. On adding CuCl2 to the ZnCl2/L system, a Cu-Zn complex was formed and a strong quenching behavior was observed, which inferred that the Cu2+ displaced Zn2+ to coordinate with the imine nitrogen atoms and hydroxyl oxygen atoms of probe L.

A naked-eye visible and turn-on fluorescence probe for Fe3+ and its bioimaging application in living cells

2016 ◽  
Vol 237 ◽  
pp. 501-508 ◽  
Author(s):  
Yaming Liu ◽  
Jinyu Zhang ◽  
Jiaxi Ru ◽  
Xiang Yao ◽  
Yang Yang ◽  
...  
Keyword(s):  
Fluorescence Probe ◽  
Living Cells ◽  
Naked Eye ◽  
Turn On

An indicator-displacement assay based on the Murexide-Hg2+ system for fluorescence turn-on detection of biothiols in biological fluids

2017 ◽  
Vol 249 ◽  
pp. 90-95 ◽  
Author(s):  
Wenfeng Zhao ◽  
Mimi Sun ◽  
Tian Lei ◽  
Xiaojun Liu ◽  
Qingquan Zhang ◽  
...  
Keyword(s):  
Biological Fluids ◽  
Turn On ◽  
Displacement Assay ◽  
Fluorescence Turn On
Sign in / Sign up

Export Citation Format

Share Document