Direct enantioselective vinylogous aldol–cyclization cascade reaction of allyl pyrazoleamides with isatins: asymmetric construction of spirocyclic oxindole–dihydropyranones

2014 ◽  
Vol 50 (74) ◽  
pp. 10790 ◽  
Author(s):  
Tian-Ze Li ◽  
Yu Jiang ◽  
Yu-Qing Guan ◽  
Feng Sha ◽  
Xin-Yan Wu
Keyword(s):  
Cascade Reaction ◽  
Aldol Cyclization ◽  
Spirocyclic Oxindole

ChemInform Abstract: Enantioselective Direct Vinylogous Aldol-Cyclization Cascade Reaction Between β,γ-Unsaturated Amides and o-Quinones.

ChemInform ◽  
2016 ◽  
Vol 47 (46) ◽  
Author(s):  
Yu Jiang ◽  
Jun-Hao Fu ◽  
Tian-Ze Li ◽  
Feng Sha ◽  
Xin-Yan Wu
Keyword(s):  
Cascade Reaction ◽  
Aldol Cyclization

One-pot asymmetric synthesis of a hexahydrophenanthridine scaffold containing five stereocenters via an organocatalytic quadruple-cascade reaction

2021 ◽  
Author(s):  
Xiao-Long Zhang ◽  
Kai-Xiang Feng ◽  
Jian-Liang Hu ◽  
Qiao-Yu Shen ◽  
Wang-Sheng Huang ◽  
...  
Keyword(s):  
Asymmetric Synthesis ◽  
Cascade Reaction ◽  
One Pot ◽  
Unsaturated Aldehydes ◽  
Aldol Cyclization

An organocatalytic enantioselective aza-Michael-Michael-Michael/aldol cyclization quadruple-cascade reaction of 2-amino-β-nitrostyrenes and α,β-unsaturated aldehydes has been developed for the construction of fully substituted hexahydrophenanthridine.

Enantioselective Construction of Spirocyclic Oxindole Derivatives with Multiple Stereocenters via an Organocatalytic Michael/Aldol/Hemiacetalization Cascade Reaction

2016 ◽  
Vol 18 (10) ◽  
pp. 2387-2390 ◽  
Author(s):  
Luyi Zhu ◽  
Qiliang Chen ◽  
Dan Shen ◽  
Weihao Zhang ◽  
Cong Shen ◽  
...  
Keyword(s):  
Cascade Reaction ◽  
Spirocyclic Oxindole

Catalytic cascade aldol–cyclization of tertiary ketone enolates for enantioselective synthesis of keto-esters with a C–F quaternary stereogenic center

2016 ◽  
Vol 14 (30) ◽  
pp. 7295-7303 ◽  
Author(s):  
Wanxing Sha ◽  
Lijun Zhang ◽  
Wenzhong Zhang ◽  
Haibo Mei ◽  
Vadim A. Soloshonok ◽  
...  
Keyword(s):  
Cascade Reaction ◽  
Enantioselective Synthesis ◽  
Keto Esters ◽  
Aldol Cyclization ◽  
Ketone Enolates ◽  
Stereogenic Center

The first enantioselective catalytic aldol–cyclization cascade reaction of detrifluoroacetylatively in situ generated tertiary enolates with methyl 2-formylbenzoate is reported.

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