Asymmetric Synthesis of Spirooxindole δ-Lactones with Vicinal Tertiary and Quaternary Stereocenters via Regio-, Diastereo-, and Enantioselective Organocatalytic Vinylogous Aldol-cyclization Cascade Reaction

2017 ◽  
Vol 359 (22) ◽  
pp. 4043-4049 ◽  
Author(s):  
Jeng-Liang Han ◽  
You-Da Tsai ◽  
Chia-Hao Chang
Keyword(s):  
Asymmetric Synthesis ◽  
Cascade Reaction ◽  
Aldol Cyclization ◽  
Quaternary Stereocenters

One-pot asymmetric synthesis of a hexahydrophenanthridine scaffold containing five stereocenters via an organocatalytic quadruple-cascade reaction

2021 ◽  
Author(s):  
Xiao-Long Zhang ◽  
Kai-Xiang Feng ◽  
Jian-Liang Hu ◽  
Qiao-Yu Shen ◽  
Wang-Sheng Huang ◽  
...  
Keyword(s):  
Asymmetric Synthesis ◽  
Cascade Reaction ◽  
One Pot ◽  
Unsaturated Aldehydes ◽  
Aldol Cyclization

An organocatalytic enantioselective aza-Michael-Michael-Michael/aldol cyclization quadruple-cascade reaction of 2-amino-β-nitrostyrenes and α,β-unsaturated aldehydes has been developed for the construction of fully substituted hexahydrophenanthridine.

Gold-catalyzed construction of two adjacent quaternary stereocenters via sequential C–H functionalization and aldol annulation

2016 ◽  
Vol 52 (11) ◽  
pp. 2257-2260 ◽  
Author(s):  
Zhunzhun Yu ◽  
Haile Qiu ◽  
Lu Liu ◽  
Junliang Zhang
Keyword(s):  
Quaternary Centers ◽  
Aldol Cyclization ◽  
Quaternary Stereocenters

A novel gold-catalyzed intermolecular C–H functionalization and aldol cyclization for the construction of two adjacent quaternary centers is presented.

ChemInform Abstract: Enantioselective Direct Vinylogous Aldol-Cyclization Cascade Reaction Between β,γ-Unsaturated Amides and o-Quinones.

ChemInform ◽  
2016 ◽  
Vol 47 (46) ◽  
Author(s):  
Yu Jiang ◽  
Jun-Hao Fu ◽  
Tian-Ze Li ◽  
Feng Sha ◽  
Xin-Yan Wu
Keyword(s):  
Cascade Reaction ◽  
Aldol Cyclization

Asymmetric synthesis of spiro[chroman-3,3′-pyrazol] scaffolds with an all-carbon quaternary stereocenter via a oxa-Michael–Michael cascade strategy with bifunctional amine-thiourea organocatalysts

RSC Advances ◽  
2015 ◽  
Vol 5 (111) ◽  
pp. 91108-91113 ◽  
Author(s):  
Weiping Zheng ◽  
Jiayong Zhang ◽  
Shuang Liu ◽  
Chengbin Yu ◽  
Zhiwei Miao
Keyword(s):  
Asymmetric Synthesis ◽  
Cascade Reaction ◽  
Quaternary Stereocenter

The chiral spiro[chroman-3,3′-pyrazol] derivatives have been synthesized through a catalytic oxa-Michael–Michael cascade reaction of 2-hydroxynitrostyrenes with 4-alkenyl pyrazolin-3-ones in good yields with moderate to high stereoselectivities.

Asymmetric synthesis of highly functionalized spirothiazolidinone tetrahydroquinolines via a squaramide-catalyzed cascade reaction

2018 ◽  
Vol 16 (48) ◽  
pp. 9390-9401 ◽  
Author(s):  
Yong-Xing Song ◽  
Da-Ming Du
Keyword(s):  
Asymmetric Synthesis ◽  
Michael Addition ◽  
Addition Reaction ◽  
Cascade Reaction ◽  
Michael Addition Reaction

A bifunctional squaramide-catalyzed asymmetric cascade aza-Michael/Michael addition reaction for the synthesis of chiral spirothiazolidinone tetrahydroquinolines with three contiguous stereocenters has been developed.

Asymmetric total synthesis of (−)-δ-lycorane

2017 ◽  
Vol 4 (6) ◽  
pp. 1149-1152 ◽  
Author(s):  
Junliang Wang ◽  
Jianneng Li ◽  
Xianwang Shen ◽  
Cong Dong ◽  
Jun Lin ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Asymmetric Synthesis ◽  
Cascade Reaction ◽  
Asymmetric Total Synthesis

A first asymmetric synthesis of (−)-δ-lycorane by using a chiral bifunctional squaramide-catalysed cascade reaction is reported.

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