scholarly journals A Robust Approach to Enhance Tumor-selective Accumulation of Nanoparticles

Oncotarget ◽  
2011 ◽  
Vol 2 (1-2) ◽  
pp. 59-68 ◽  
Author(s):  
Yuan Qiao ◽  
Xin Huang ◽  
Sridhar Nimmagadda ◽  
Renyuan Bai ◽  
Verena Staedtke ◽  
...  
Keyword(s):  
Robust Approach ◽  
Selective Accumulation ◽  
Tumor Selective

scholarly journals Biological reduction of nitroimidazole-functionalized gold nanorods for photoacoustic imaging of tumor hypoxia

RSC Advances ◽  
2019 ◽  
Vol 9 (29) ◽  
pp. 16863-16868 ◽  
Author(s):  
Yui Umehara ◽  
Toki Kageyama ◽  
Aoi Son ◽  
Yu Kimura ◽  
Teruyuki Kondo ◽  
...  
Keyword(s):  
Gold Nanorods ◽  
Photoacoustic Imaging ◽  
Tumor Hypoxia ◽  
Biological Reduction ◽  
Selective Accumulation ◽  
Tumor Selective

Tumor-selective accumulation of gold nanorods (GNR) has been demonstrated for visualization of tumor hypoxia by photoacoustic imaging.

Hybrid polymer micelles capable of cRGD targeting and pH-triggered surface charge conversion for tumor selective accumulation and promoted uptake

2014 ◽  
Vol 50 (65) ◽  
pp. 9188-9191 ◽  
Author(s):  
Xiuli Hu ◽  
Xingang Guan ◽  
Jing Li ◽  
Qing Pei ◽  
Ming Liu ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Surface Charge ◽  
Active Targeting ◽  
Hybrid Polymer ◽  
Polymer Micelles ◽  
Dual Functional ◽  
Stimuli Response ◽  
Selective Accumulation ◽  
Tumor Selective

Dual functional micelles combining active targeting (cRGD) and tumor microenvironment stimuli response used for Dox delivery.

Enzyme-triggered supramolecular self-assembly of platinum prodrug with enhanced tumor-selective accumulation and reduced systemic toxicity

2014 ◽  
Vol 2 (47) ◽  
pp. 8303-8309 ◽  
Author(s):  
Huan Liu ◽  
Yanli Li ◽  
Zhonglin Lyu ◽  
Yingbo Wan ◽  
Xiaohong Li ◽  
...  
Keyword(s):  
Self Assembly ◽  
Systemic Toxicity ◽  
Drug Accumulation ◽  
Self Assembled ◽  
Selective Accumulation ◽  
Tumor Selective

A self-assembled Pt prodrug with enhanced drug accumulation in tumor areas was achieved through the catalysis of a locally expressed enzyme.

scholarly journals Towards a computational prediction for the tumor selective accumulation of paramagnetic nanoparticles in retinoblastoma cells

2018 ◽  
pp. 68-73
Author(s):  
R.J. Johansen ◽  
A.A. Bukhvostov ◽  
K.V. Ermakov ◽  
D.A. Kuznetsov
Keyword(s):  
Targeted Delivery ◽  
Computational Prediction ◽  
Drug Uptake ◽  
Tumor Growth Rate ◽  
Preclinical Research ◽  
Retinoblastoma Cells ◽  
Starting Point ◽  
Human Retinoblastoma ◽  
Selective Accumulation ◽  
Tumor Selective

Retinoblastoma is a malignant growth affecting retina. An original combination of modified Non-Markov and Gompertzian computational approaches is proven of being a reliable tool for prediction of tumor selective accumulation of the bivalent metal isotopes (25Mg, 43Ca, 60Co, 67Zn, …) — releasing nanoparticles in human retinoblastoma cells. This mathematical model operates with a starting point of the discriminative drug uptake caused by a gap-like distinction between the neighboring malignant and normal cell proliferation rates. This takes into account both pharmacokinetic and pharmacodynamic peculiarities of PMC16, fullerene-C60 based nanoparticles, known for their unique capabilities for a cancer-targeted delivery of paramagnetic metal isotopes followed by an essential chemotherapeutic effect. Being dependent on a tumor growth rate but not on the neoplasm steady state mass, a randomized level of drug accumulation in retinoblastoma cells has been formalized as a predictive paradigm suitable to optimize an ongoing PMC16 preclinical research.

The oncolytic adenovirus Ad-iREP-2 utilizes p53-dependent rna interference for tumor-selective replication

2008 ◽  
Vol 46 (09) ◽  
Author(s):  
E Gürlevik ◽  
P Schache ◽  
L Zender ◽  
MP Manns ◽  
S Kubicka ◽  
...  
Keyword(s):  
Rna Interference ◽  
Oncolytic Adenovirus ◽  
Tumor Selective

Hand Shape Coding: A Robust Approach for Human Identity Verification

2014 ◽  
Vol 1 (3) ◽  
pp. 8-17
Author(s):  
Shefali Sharma ◽  
◽  
Ashutosh Kumar Singh ◽  
Rajiv Saxena ◽  
◽  
...  
Keyword(s):  
Human Identity ◽  
Identity Verification ◽  
Robust Approach ◽  
Hand Shape ◽  
Shape Coding
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