Synthesis of a novel cross-linker doubles as a functional monomer for preparing a water compatible molecularly imprinted polymer

2014 ◽  
Vol 6 (23) ◽  
pp. 9483-9489 ◽  
Author(s):  
Xiao Zhang ◽  
Feng Shen ◽  
Zhe Zhang ◽  
Yue Xing ◽  
Xueqin Ren
Keyword(s):  
Molecularly Imprinted Polymer ◽  
Naproxen Sodium ◽  
Functional Monomer ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Bifunctional Monomer ◽  
Cross Linker

A new bifunctional monomer acting as both a cross-linker and a functional monomer was synthesized and applied in the preparation of water-compatible naproxen sodium imprinted polymers.

Cyromazine imprinted polymers for selective stir bar sorptive extraction of melamine in animal feed and milk samples

The Analyst ◽  
2015 ◽  
Vol 140 (12) ◽  
pp. 4057-4067 ◽  
Author(s):  
Wenying Fan ◽  
Mingqi Gao ◽  
Man He ◽  
Beibei Chen ◽  
Bin Hu
Keyword(s):  
Molecularly Imprinted Polymer ◽  
Animal Feed ◽  
Stir Bar Sorptive Extraction ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Milk Samples ◽  
Sorptive Extraction ◽  
Dummy Template

A molecularly imprinted polymer coated stir bar was prepared using a self-designed polytetrafluoroethylene mold andin situpolymerization, with cyromazine as dummy template for target melamine.

scholarly journals Solid-phase extraction of selected acidic pharmaceuticals from wastewater using a molecularly imprinted polymer

2017 ◽  
Author(s):  
◽  
Silindile Senamile Zunngu
Keyword(s):  
Binding Energy ◽  
Solid Phase Extraction ◽  
Solid Phase ◽  
Deionized Water ◽  
Phase Extraction ◽  
Functional Monomer ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Functional Monomers ◽  
Cross Linker

In this study, molecular modeling was used to investigate the intermolecular interactions between the functional monomer and ketoprofen which is an acidic pharmaceutical that possesses anti-inflammatory and analgesic activities. Ketoprofen is widely employed in medical care for treating musculoskeletal injury. This led to rational design of a molecularly imprinted polymer (MIP) that is selective to ketoprofen. Density functional theory (DFT) at B3LYP/6-31 level was used to investigate the intermolecular interaction between functional monomers and ketoprofen. Binding energy, ΔE, was used as an indication of the strength of the interaction that occurs between functional monomers and ketoprofen. 2-vinylpyridine (2-VP) as one of the functional monomers gave the lowest binding energy when compared to all the functional monomers investigated. Monomer-template interactions were further experimentally investigated using spectroscopic techniques such as Ultraviolet-visible and Fourier transform infrared (FTIR). A selective MIP for ketoprofen was synthesized using 2-vinylpyridine, ethylene glycol dimethacrylate, 1,1’-azobis(cyclohexanecarbonitrile), toluene/acetonitrile (9:1, v/v), and ketoprofen as a functional monomer, cross-linker, initiator, porogenic mixture, and template, respectively. The polymerization was performed at 60 °C for 16 h, and thereafter the temperature was increased to 80 °C for 24 h to achieve a solid monolith polymer. The non-imprinted polymer (NIP) was synthesized in a similar manner with the omission of ketoprofen. Characterization with thermogravimetric analysis (TGA) and powder X-ray diffraction (XRD) showed that the synthesized polymers were thermally stable and amorphous. Morphology of the particles were clearly visible, with MIP showing rough and irregular surface compared to NIP on the scanning electron microscopy (SEM). The characterization of the prominent functional groups on both MIP and NIP were performed using FTIR and nuclear magnetic resonance (NMR). The existence of hydroxyl was observed in the MIP; this was due to the presence of ketoprofen in the cavity. Prominent carbonyl group was an indication of the cross-linker present in both polymers. The synthesized MIP was applied as a selective sorbent in the solid-phase extraction of ketoprofen from the water. The extracted ketoprofen was monitored by high performance liquid chromatography (HPLC) coupled with UV/Vis detector. Several parameters were investigated for maximum recovery of ketoprofen from the spiked deionized water. The optimum method involved the conditioning of 14 mg MIP sorbent with 5 mL of methanol followed by equilibrating with 5 mL of deionized water adjusted to pH 2.5. Thereafter, 50 mL sample (pH 5) was loaded into the cartridge containing MIP sorbent followed by washing and eluting with 1% TEA/H2O and 100% methanol, respectively. Eluted compounds were quantified with HPLC. MIP was more selective to ketoprofen in the presence of other structural related competitors. The analytical method gave detection limits of 0.23, 0.17, and 0.09 mg L-1 in wastewater influent, effluent, and deionized water, respectively. The recovery for the wastewater influent and effluent spiked with 5 µg L-1 of ketoprofen was 68%, whereas 114% was obtained for deionized water. The concentrations of ketoprofen in the influent and effluent samples were in the ranges of 22.5 - 34.0 and 1.14 - 5.33 mg.L-1, respectively. The relative standard deviation (RSD) given as ± values indicates that the developed analytical method for the analysis of ketoprofen in wastewater was rapid, affordable, accurate, precise, sensitive, and selective.

Application of Response Surface Methodology to Synthesize Appropriate Molecularly Imprinted Polymer for Diazinon

2014 ◽  
Vol 605 ◽  
pp. 67-70 ◽  
Author(s):  
Mohsen Rahiminezhad ◽  
Seyed Jamaleddin Shahtaheri ◽  
Mohammad Reza Ganjali ◽  
Abbas Rahimi Rahimi Forushani
Keyword(s):  
Molecular Imprinting ◽  
Molecularly Imprinted Polymer ◽  
Binding Sites ◽  
Capillary Electrochromatography ◽  
Template Molecule ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Functional Monomers ◽  
Molecular Imprinting Technology ◽  
Cross Linker

Molecular imprinting technology has become an interesting research area to the preparation of specific sorbent material for environmental and occupational sample preparation techniques (1). In the molecular imprinting technology, specific binding sites have been formed in polymeric matrix, which often have an affinity and selectivity similar to antibody-antigen systems (2). In molecular imprinted technology, functional monomers are arranged in a complementary configuration around a template molecule, then, cross-linker and solvent are also added and the mixture is treated to give a porous material containing nono-sized binding sites. After extraction of the template molecule by washing, vacant imprinted sites will be left in polymer, which are available for rebinding of the template or its structural analogue (3). The stability, convention of preparation and low cost of these materials make them particularly attractive (4). These synthetic materials have been used for capillary electrochromatography (5), chromatography columns (6), sensors (7), and catalyze system (8). Depending on the molecular imprinting approach, different experimental variables such as the type and amounts of functional monomers, porogenic solvent, initiator, monomer to cross-linker ratio, temperature, and etc may alter the properties of the final polymeric materials. In this work, chemometric approach based on Central Composite Design (CCD) was used to design the experiments as well as to find the optimum conditions for preparing appropriate diazinon molecularly imprinted polymer.

Synthesis, characterization and in vivo drug delivery study of a biodegradable nano-structured molecularly imprinted polymer based on cross-linker of fructose

Polymer ◽  
2016 ◽  
Vol 97 ◽  
pp. 226-237 ◽  
Author(s):  
Ebadullah Asadi ◽  
Majid Abdouss ◽  
Roger M. Leblanc ◽  
Noushin Ezzati ◽  
James N. Wilson ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Molecularly Imprinted Polymer ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Cross Linker

scholarly journals Application of molecularly imprinted polymer designed for the selective extraction of ketoprofen from wastewater

Water SA ◽  
2018 ◽  
Vol 44 (3 July) ◽  
Author(s):  
Lawrence Mzukisi Madikizela ◽  
Silindile Senamile Zunngu ◽  
Nomchenge Yamkelani Mlunguza ◽  
Nikita Tawanda Tavengwa ◽  
Phumlane Selby Mdluli ◽  
...  
Keyword(s):  
Molecularly Imprinted Polymer ◽  
Selective Extraction ◽  
Bulk Polymerization ◽  
Selectivity Coefficient ◽  
Dynamics Simulation ◽  
Maximum Adsorption Capacity ◽  
Order Kinetic ◽  
Functional Monomer ◽  
Imprinted Polymer ◽  
Molecularly Imprinted

A molecularly imprinted polymer (MIP) that is selective to ketoprofen was synthesized and applied in the adsorption of the target compound from water. The MIP was synthesized using a bulk polymerization method at high temperatures (60–80°C), where ketoprofen, 2-vinylpyridine, ethylene glycol dimethacrylate, toluene and 1,1´-azobis(cyclohexanecarbonitrile) were used as template, functional monomer, cross-linker, porogen and initiator, respectively. Non-imprinted polymer (NIP) was synthesized similarly to the MIP but in the absence of ketoprofen. From molecular dynamics simulation, the nature of interactions that occurred between the template and the functional monomer were found to be based on hydrogen bonding. This was confirmed experimentally, where a high extraction efficiency of ≥ 90% was obtained at acidic conditions (pH 5) due to the protonation of ketoprofen. A contact time of 45 min was sufficient for the maximum adsorption of ketoprofen from 10 mL spiked water using 8 mg of the adsorbent. MIP showed greater selectivity than NIP by achieving a relative selectivity coefficient of 7.7 towards ketoprofen in the presence of structurally related pharmaceuticals. Furthermore, the order of sorption onto the MIPs from water was ketoprofen > fenoprofen > gemfibrozil. From a modelling perspective, the Langmuir adsorption isotherm and pseudo-second-order kinetic model gave the best fit, with maximum adsorption capacity of 8.24 mg·g−1 and sorption rate constant of 0.25 mg·g−1·min−1 for MIP. This was translated to chemisorption of ketoprofen onto the homogeneous MIP binding sites. This work demonstrated the great potential of MIP in selective recognition of ketoprofen from wastewater relative to closely related compounds.

Cationic pTyr/pSer imprinted polymers based on a bis-imidazolium host monomer: phosphopeptide recognition in aqueous buffers demonstrated by μ-liquid chromatography and monolithic columns

2017 ◽  
Vol 5 (5) ◽  
pp. 953-960 ◽  
Author(s):  
Celina Wierzbicka ◽  
Mingquan Liu ◽  
David Bauer ◽  
Knut Irgum ◽  
Börje Sellergren
Keyword(s):  
Liquid Chromatography ◽  
Polymer Films ◽  
Molecularly Imprinted Polymer ◽  
Monolithic Columns ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Phosphorylated Peptides

Capillary monoliths featuring grafted molecularly imprinted polymer films incorporating on a bis-imidazolium host monomer, displayed a remarkable crossreactivity with phosphorylated peptides in buffered media.

Recent developments in molecularly imprinted polymer nanofibers and their applications

2015 ◽  
Vol 7 (18) ◽  
pp. 7406-7415 ◽  
Author(s):  
Shabi Abbas Zaidi
Keyword(s):  
Molecularly Imprinted Polymer ◽  
Molecularly Imprinted Polymers ◽  
Imprinted Polymer ◽  
Polymer Nanofibers ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Recent Developments ◽  
Analyte Detection

Molecularly imprinted polymers (MIPs) have been potential and versatile candidates for analyte detection.

Stoichiometric molecular imprinting using polymerisable urea and squaramide receptors for the solid phase extraction of organo-arsenic compound roxarsone

2020 ◽  
Vol 12 (47) ◽  
pp. 5729-5736
Author(s):  
Simone Cavalera ◽  
Fabio Di Nardo ◽  
Giulia Spano ◽  
Laura Anfossi ◽  
Panagiotis Manesiotis ◽  
...  
Keyword(s):  
Solid Phase Extraction ◽  
Molecular Imprinting ◽  
Surface Waters ◽  
Molecularly Imprinted Polymer ◽  
Solid Phase ◽  
Phase Extraction ◽  
Functional Monomer ◽  
Arsenic Compound ◽  
Imprinted Polymer ◽  
Molecularly Imprinted

A selective molecularly imprinted polymer prepared with a squaramide-based functional monomer was used for the solid phase extraction of roxarsone from surface waters.

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